RESUMEN
Experimental comparative morphological investigation of hemomicrocirculation bed (HMCB) of the small and large bowel wall was performed in dynamics of an acute serous peritonitis. Spreaded aseptic peritonitis was simulated using injection of 5 ml of gamma-caraginen (Sigma, USA) in 1 ml of isotonic solution of sodium chloride. On the early stage of peritonitis (in 12 h from beginning of the experiment) in mucosa of small bowel nonsignificant venuls dilatation and the capillary lumen reduction were observed. In 1 day (reactive stage of peritonitis) in mucosa the quantity of capillars have had reduced significantly, comparing with such observed previously. On the 2-nd day (toxic stage of peritonitis) some capillary dilatation in intestinal villi and crypts coexistant with the blood rheology disorders in a form of stasis, change in permeability of the vessels walls, predominantly of the venous, was noted. On the 3-d day (late stage) the arteriol's spasm have had reduced, capillary paralytic dilatation was revealed. The staged course of experimental peritonitis with the HMCB changes, characteristic for every stage, was confirmed, basing on analysis of the investigation result.
Asunto(s)
Intestino Grueso/irrigación sanguínea , Intestino Delgado/irrigación sanguínea , Microcirculación/fisiología , Microvasos/fisiopatología , Peritonitis/fisiopatología , Enfermedad Aguda , Animales , Modelos Animales de Enfermedad , Mucosa Intestinal/irrigación sanguínea , Mucosa Intestinal/fisiopatología , Intestino Grueso/fisiopatología , Intestino Delgado/fisiopatología , Microvasos/patología , Peritonitis/patología , Ratas , Ratas Wistar , Factores de Tiempo , Vasodilatación/fisiologíaRESUMEN
The analysis of prognostic value of APACHE II scale in estimation of the severity state in patients with an acute sepsis was presented. There was proposed the scale of estimation of the severity state in patients with an acute sepsis.
Asunto(s)
Sepsis/diagnóstico , Índice de Severidad de la Enfermedad , APACHE , Enfermedad Aguda , Humanos , Valor Predictivo de las Pruebas , Sepsis/mortalidadRESUMEN
In 90 patients with an acute sepsis application of cryopreserved hepatocytes and splenic sections had promoted detoxication and immunocorrection, improved the rehabilitational indexes significantly.
Asunto(s)
Hemoperfusión/métodos , Leucocitosis/inmunología , Leucocitosis/terapia , Sepsis/terapia , Enfermedad Aguda , Diabetes Mellitus Tipo 1/complicaciones , Humanos , Leucocitosis/diagnóstico , Plasmaféresis/métodos , Estudios Retrospectivos , Sepsis/etiología , Infección de la Herida Quirúrgica/complicaciones , Resultado del TratamientoRESUMEN
The mechanism of the development of the syndrome of endogenous intoxication at the early postoperative period in patients with toxic phase of peritonitis is considered. A method for detoxication-extracorporeal hemoperfusion through cryoconservated xenohepatocytes, which permits to reduce the severity of endogenous intoxication and to activize the natural detoxicative systems of the organism is suggested.
Asunto(s)
Criopreservación , Hemoperfusión/métodos , Hígado/citología , Peritonitis/cirugía , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Cuidados Posoperatorios/métodos , Factores de TiempoRESUMEN
The results of treatment of 440 patients with obliterative diseases of the arteries of the lower extremities are presented. Use of the ultra-violet rays for extracorporeal irradiation of the blood in combination with discrete plasmapheresis has a pronounced therapeutic effect, contributes to improvement in regional blood flow and shortening the duration of patients' staying in the hospital by 5-7 days.