Asunto(s)
Adenocarcinoma/terapia , Neoplasias de las Trompas Uterinas/terapia , Adenocarcinoma/patología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Terapia Combinada , Neoplasias de las Trompas Uterinas/patología , Femenino , Estudios de Seguimiento , Humanos , Histerectomía , Persona de Mediana EdadAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Ováricas/tratamiento farmacológico , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Cisplatino/administración & dosificación , Cisplatino/efectos adversos , Terapia Combinada , Ciclofosfamida/administración & dosificación , Ciclofosfamida/efectos adversos , Doxorrubicina/administración & dosificación , Doxorrubicina/efectos adversos , Femenino , Humanos , Persona de Mediana Edad , Metástasis de la Neoplasia , Estadificación de Neoplasias , Compuestos Organoplatinos/efectos adversos , Compuestos Organoplatinos/uso terapéutico , Neoplasias Ováricas/mortalidad , Neoplasias Ováricas/patología , Platino (Metal)/efectos adversos , Platino (Metal)/uso terapéutico , Factores de TiempoRESUMEN
The results of the treatment of 75 patients with ovarian carcinoma of epithelial origin are reported. The authors give a randomised clinical comparison of the efficacy of two schemes of complex treatment of 54 patients with ascitic ovarian carcinoma and 21 patients with non-ascitic ovarian carcinoma. The first scheme included cytoxan chemotherapy plus surgery plus polychemotherapy (25 patients); the second--surgery plus polychemotherapy (29 patients). Patients with non-ascitic carcinoma (21) received the second type of treatment. Polychemotherapy consisted of two alternating schedules: 5 fluorouracil plus cyclophosphamide and hexamethylamine plus cyclophosphamide after a two week interval. Better results were obtained in the group of patients treated surgically at the initial stage of treatment.
Asunto(s)
Neoplasias Ováricas/terapia , Castración , Quimioterapia Combinada , Femenino , Humanos , Estadificación de Neoplasias , Neoplasias Ováricas/mortalidad , Neoplasias Ováricas/patología , Cuidados Posoperatorios/métodos , Pronóstico , Factores de TiempoRESUMEN
An evaluation of 801 cases of different forms of uterine trophoblastic tumors treated at the Center in 1960-1981 is given. Chorionepithelioma was confirmed histologically in 488 cases. Modern means of diagnosis of uterine trophoblastic tumors are discussed. A retrospective analysis of treatment of patients is presented. The result of up-to-date combination chemotherapy of patients with uterine chorionepithelioma are reported. The role of surgery in the treatment of trophoblastic tumors is discussed.
Asunto(s)
Neoplasias Trofoblásticas/diagnóstico , Neoplasias Uterinas/diagnóstico , Adulto , Coriocarcinoma/diagnóstico , Coriocarcinoma/mortalidad , Coriocarcinoma/terapia , Gonadotropina Coriónica/sangre , Femenino , Humanos , Estadificación de Neoplasias , Embarazo , Glicoproteínas beta 1 Específicas del Embarazo/análisis , Neoplasias Trofoblásticas/mortalidad , Neoplasias Trofoblásticas/terapia , Neoplasias Uterinas/mortalidad , Neoplasias Uterinas/terapiaRESUMEN
The results of treatment of 50 patients with ovarian cancer (serous carcinoma) are reported. At the first step all the patients were treated surgically. Following the operation the combined chemotherapy was employed with three schedules: 1. 5-fluoruracil-cyclophosphane--26 patients; 2. 5-fluoruracil-cyclophosphane-methotrexate-hexamethyl melamine--16 patients; 3. fluorofur-cyclophosphane-methotrexate-hexamethyl melamine--8 patients. An analysis of the results of the treatment in ovarian cancer patients has demonstrated that a positive therapeutic effect may be gained using each of the schedules of the polychemotherapy employed, of special importance being such factors as the degree of tumor proliferation, radicality of surgical intervention and the magnitude of toxic reactions of antitumor drugs.
Asunto(s)
Antineoplásicos/administración & dosificación , Neoplasias Ováricas/terapia , Ovario/cirugía , Altretamina/administración & dosificación , Carcinoma/terapia , Ciclofosfamida/administración & dosificación , Quimioterapia Combinada , Estudios de Evaluación como Asunto , Femenino , Fluorouracilo/administración & dosificación , Humanos , Metotrexato/administración & dosificación , Cuidados Posoperatorios , Tegafur/administración & dosificación , Factores de TiempoAsunto(s)
Neoplasias Ováricas/terapia , Castración , Relación Dosis-Respuesta a Droga , Evaluación de Medicamentos , Quimioterapia Combinada , Femenino , Humanos , Histerectomía , Metástasis de la Neoplasia , Recurrencia Local de Neoplasia/terapia , Estadificación de Neoplasias , Neoplasias Ováricas/clasificación , Neoplasias Ováricas/diagnóstico , Pronóstico , RadioterapiaAsunto(s)
Neoplasias Trofoblásticas/diagnóstico , Neoplasias Uterinas/diagnóstico , Coriocarcinoma/diagnóstico , Femenino , Humanos , Mola Hidatiforme/diagnóstico , Metástasis de la Neoplasia , Estadificación de Neoplasias , Embarazo , Pronóstico , Neoplasias Trofoblásticas/terapia , Neoplasias Uterinas/terapiaRESUMEN
By using DNCB delayed hypersensitivity test, the reaction of spontaneous rosette formation (RSRF) and the reaction of inhibition of leucocytes migration the authors examined 55 female patients with different forms of trophoblastic tumors of the uterus and 15 females following the removal of the mole without any signs of the disease concerned. Forty three patients showed a positive DNCB test, 93 of them were completely cured, a negative test was noted in 12 patients, only a 50% cure being observed. RSRF indicated the increased level of rosette-forming cells from 4,7--28% up to 10,3--73% in a successful treatment and its decrease down to 0--5% in the tumor progression, except 7 patients showing reduced RFC levels after the recovery. The reaction of leucocytes migration inhibition has revealed a considerable depression of leucocytes migration (MI--from 0.35 to 0.78) in 18 of 25 patients with manifestations of an acute tumor process (72%). In 7 cases no inhibition was noted, in 6--the treatment being insignificantly effective or time-consuming. In 21 (47.8%) of 27 patients without any signs of the affection there was no inhibitory effect. Leucocytes of healthy donors failed to respond to the tumor extract in either of 24 cases.