RESUMEN
Comunicamos un caso de eritema indurado de Bazin-vasculitis nodular en una mujer de 22 años, con una reacción fuertemente positiva al test de la tuberculina, lesiones ulceradas y una buena respuesta a la terapia anti tuberculosa hasta el momento. Se discute la ubicación nosológica de esta entidad y se enfatiza sobre la necesidad de una biopsia amplia adecuada.
A 22-old woman with an erythema induratum de Bazin-nodular vasculitis was reported, the tuberculin test was strongly positive measuring 17 mm of diameter. The patient had indolent ulcerated lesions, the therapy with four anti-tuberculous drugs results effective until now. The existence of the entity as unique or not as well the need of a wide biopsy is discussed.
RESUMEN
Comunicamos un caso de eritema indurado de Bazin-vasculitis nodular en una mujer de 22 años, con una reacción fuertemente positiva al test de la tuberculina, lesiones ulceradas y una buena respuesta a la terapia anti tuberculosa hasta el momento. Se discute la ubicación nosológica de esta entidad y se enfatiza sobre la necesidad de una biopsia amplia adecuada.(AU)
A 22-old woman with an erythema induratum de Bazin-nodular vasculitis was reported, the tuberculin test was strongly positive measuring 17 mm of diameter. The patient had indolent ulcerated lesions, the therapy with four anti-tuberculous drugs results effective until now. The existence of the entity as unique or not as well the need of a wide biopsy is discussed.(AU)
RESUMEN
Comunicamos un caso con dos melanomas "in situ", en un varón de 86 años, localizados en ambos lados de la cara con alto riesgo quirúrgico, quien fuera tratado con imiquimod al 5% una vez al día durante dos meses; los resultados hasta el momento, clínicos e histológicos han sido satisfactorios.
A 86 years-old man with two melanomas "in situ" at both sides of his face, treated with imiquimod 5% are presented. The patient has a cardiovascular high risk due to isquemic heart disease, for that reason we start the treatment with imiquimod once a day for two months. The clinical and histological response was good and a follow up will be as long as we can.
RESUMEN
Comunicamos un caso con dos melanomas "in situ", en un varón de 86 años, localizados en ambos lados de la cara con alto riesgo quirúrgico, quien fuera tratado con imiquimod al 5% una vez al día durante dos meses; los resultados hasta el momento, clínicos e histológicos han sido satisfactorios.(AU)
A 86 years-old man with two melanomas "in situ" at both sides of his face, treated with imiquimod 5% are presented. The patient has a cardiovascular high risk due to isquemic heart disease, for that reason we start the treatment with imiquimod once a day for two months. The clinical and histological response was good and a follow up will be as long as we can.(AU)
RESUMEN
In this study we investigated the pharmacokinetics of a hematoporphyrin derivative (Photogem) in Wistar rats using the fluorescence spectroscopy to evaluate the drug distribution in liver, kidney and skin tissues. The detection system is composed of a 532 nm exciting laser, a Y-type catheter for light delivery and collection, a monochromator and a computer for data acquisition. The analysis of the fluorescence spectra was based on the intensity of porphyrin emission bands from specific tissues of the investigated organ. A simple transport model is proposed to determine the accumulation and elimination times for each type of investigated tissue. The obtained results show the viability of the fluorescence spectroscopic technique for the drug concentration monitoring in different target tissues and related pharmacokinetics. These effects should be considered before any in vivo study of Photodynamic Therapy using Photogem.