RESUMEN
A 65-year-old female presented with a one-and-a-half-year history of intermittent, painless, gross hematuria. She was found to have a large bladder neoplasm. A cytologic diagnosis of signet-ring-cell (colloid) carcinoma was made on a bladder washing and was confirmed histologically by a cystoscopic biopsy. Subsequently, a radical cystectomy was performed. The cytologic findings of this rare pure signet-ring-cell carcinoma of the bladder, not previously described, are presented along with the histologic and ultrastructural findings.
Asunto(s)
Adenocarcinoma Mucinoso/patología , Neoplasias de la Vejiga Urinaria/patología , Adenocarcinoma Mucinoso/ultraestructura , Anciano , Biopsia , Nucléolo Celular/ultraestructura , Núcleo Celular/ultraestructura , Citoplasma/ultraestructura , Epitelio/patología , Femenino , Humanos , Microscopía Electrónica , Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/ultraestructura , Vacuolas/ultraestructuraRESUMEN
The clinicopathologic features of a malignant fibrous histiocytoma arising in a female breast are presented. Seven cases have been previously reported. These may be divided into three subgroups based on history and pathologic findings. Three of the seven occurred in women without a history of other tumors or previous irradiation. One appeared with a cystosarcoma phyllodes, and three arose following radiation for carcinoma of the breast. The patient in this study had received no radiation. Treatment has been based on surgical resection; the roles of chemotherapy and radiation are uncertain. Although resection alone in the first subgroup has lead to no reported mortality, the small number of cases and the relatively short follow-up does not allow a meaningful assessment of the prognosis in this disease.