RESUMEN

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the data quality and the well being of our animal subjects. Of particular interest for us has been the use of telemetry-based data acquisition for conducting studies on cardiovascular (CV) function. This includes the evolving technical aspects of the studies, as well as the development of new applications that take advantage of this technical approach.

Asunto(s)

Fármacos Cardiovasculares , Sistema Cardiovascular , Animales , Electrocardiografía , Frecuencia Cardíaca , Telemetría , Fármacos Cardiovasculares/efectos adversos , Presión Sanguínea