RESUMEN
Thymomas are relatively rare tumours of the anterior mediastinum, constituting approximately 10-15% of all mediastinal tumours. In contrast to other neoplasms, they rarely present distant metastases. We describe a case of thymoma with long survival and skin metastases diagnosed by two-colour flow cytometry.
Asunto(s)
Citometría de Flujo , Neoplasias Cutáneas/secundario , Timoma/secundario , Neoplasias del Timo/diagnóstico , Adulto , Antígenos CD1/análisis , Complejo CD3/análisis , Linfocitos T CD4-Positivos/patología , Linfocitos T CD8-positivos/patología , Diagnóstico Diferencial , Humanos , Masculino , Piel/patología , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/patología , Timoma/diagnóstico , Timoma/patología , Neoplasias del Timo/patologíaRESUMEN
The authors present the results of surgical treatment of pleural empyema by transposition of skeletal muscles into the pleural cavity. 50 patients with chronic pleural empyema of different origin were treated in Thoracic Surgery Department in Lublin in the years 1995-1998. Patients were after thoracotomy with lung tissue resection, in its majority due to neoplastic diseases. The healing process was completed per primam intentionem in 1/3 of the patients who were operated on. After 3 months the number of cured patients increased to 72.0%, and after 1 year to 84%. The hospital death rate after surgery was 6%. Because of partial obliteration of pleural cavity 25 patients were secondary treated with extended drainage or modified Clagett's method. The best results occurred when complete obliteration of pleural cavity was acquired primarily. In large empyemas it was necessary to perform supplementary thoracoplasty or filling the residual cavity with proper antibiotics solution.
Asunto(s)
Empiema Pleural/cirugía , Músculo Esquelético/cirugía , Adulto , Anciano , Enfermedad Crónica , Drenaje/métodos , Empiema Pleural/etiología , Femenino , Humanos , Neoplasias Pulmonares/complicaciones , Masculino , Persona de Mediana Edad , Pronóstico , Toracotomía , Cicatrización de HeridasAsunto(s)
Antígenos CD/análisis , Empiema Pleural/inmunología , Adulto , Anciano , Enfermedad Crónica , Empiema Pleural/complicaciones , Empiema Pleural/cirugía , Femenino , Estudios de Seguimiento , Humanos , Inmunoglobulina M/sangre , Células Asesinas Naturales/inmunología , Subgrupos Linfocitarios , Masculino , Persona de Mediana Edad , Monitoreo Fisiológico , Neoplasias/complicaciones , Neoplasias/inmunología , Valores de ReferenciaRESUMEN
Surgical experiment of closing broncho-pleural fistula by muscle flap from the chest wall was conducted on the sheep model. The procedure was completed in two stages. During the first thoracotomy the middle lobe of the right lung was removed. In the second stage the vascularised muscle flap of the latissimus dorsi was inserted in the pleural space and stitched onto the bronchi stump closing broncho-pleural fistula. Microscopic investigation of lung, bronchus and muscle tissue performed after each step of procedure showed the inflammatory process primarily and the regression of it after the second stage. Well vascularised muscle flap is the best tissue for repair of broncho-pleural fistula.
Asunto(s)
Fístula Bronquial/cirugía , Enfermedades Pleurales/cirugía , Colgajos Quirúrgicos , Animales , Femenino , Masculino , Músculo Esquelético/trasplante , OvinosRESUMEN
Initial results are presented on the usefulness of evaluating serum amyloid protein A (SAA) contents in patients operated for bronchial cancer. In the group of 20 analysed cases, blood was taken 1 day before and 1, 3, 7, 10 and 14 days after the surgical intervention, and in complicated cases-21 and 30 days after surgery. Erythrocyte sedimentation, leucocyte level, serum amyloid protein A content were measured. The extent of the intervention, the progression of the neoplastic process, clinical and radiological data were analysed. The control group consisted of 10 healthy volunteers. Amyloid protein A was evaluated by ELISA. Statistical analysis was performed on results obtained in 3 groups of patients, divided based on the extent of pulmonary resection. In all patients a statistically significant increase in SAA content was observed on the day preceding the surgery as well as 1, 3, 7 and 10 days after the surgery, in comparison with the control group. SAA level increase, in comparison with the preoperative examination, was statistically significant 1 and 3 days postoperatively in patients after pulmonectomy and only 3 days postoperatively after lobectomy. The lack of statistically significant differences in group 3 (after thoracotomy) resulted from very high preoperative values associated with the advanced progression of the neoplastic process.
Asunto(s)
Biomarcadores de Tumor/sangre , Neoplasias de los Bronquios/sangre , Neoplasias de los Bronquios/cirugía , Proteína Amiloide A Sérica/análisis , Adulto , Anciano , Ensayo de Inmunoadsorción Enzimática , Humanos , Persona de Mediana Edad , Periodo Posoperatorio , Procedimientos Quirúrgicos TorácicosRESUMEN
Initial results are presented on the usefulness of haptoglobin content monitoring in blood serum of patients after thoracic operations performed for various indications. 57 patients were analysed and divided into 3 groups based on the type of disease. Group 1 consisted of patients operated for malignant neoplasm. Group 2 consisted of patients with inflammatory changes and purulent complications within the thorax. Group 3 consisted of patients operated from other indications. The experimental samples of further 30 operated patients have not been analysed yet due to a delay in shipment of plates from Boehringer. The control group consisted of 31 healthy volunteers. In the experimental groups blood was taken 1 day before and 1, 3, 7, 10 and 14 days after the surgical intervention and in the case of complications-21 and 30 days after surgery. Erythrocyte sedimentation, leucocyte level, serum haptoglobin content, clinical and radiological data were analysed. Haptoglobin content was measured using the radial immunodiffusion method according to Manchini. Results were analysed statistically. The increase in serum haptoglobin content in patients after thoracic surgeries and after purulent complications, shows that haptoglobin is a sensitive acute phase indicator and its monitoring may be useful in evaluating the disease process. In advanced neoplastic processes haptoglobin content is a reflection of the progression of the disease process.