RESUMEN
The influence of consumption of rations containing canned baby foods from mirror carp and Black Sea mullet on severity of system anaphylactic reaction to model food allergen in rats was studied and the level of antibodies to proteins of Black Sea mullet, mirror carp, Alaska Pollack, trout and big head was determined in serum of infants, suffering from food allergy through immune-enzyme analysis.
Asunto(s)
Proteínas en la Dieta/efectos adversos , Peces , Hipersensibilidad a los Alimentos/inmunología , Conservación de Alimentos , Alimentos Infantiles/efectos adversos , Alérgenos/efectos adversos , Alérgenos/inmunología , Anafilaxia/etiología , Anafilaxia/inmunología , Alimentación Animal , Animales , Formación de Anticuerpos/inmunología , Niño , Preescolar , Proteínas en la Dieta/inmunología , Modelos Animales de Enfermedad , Grano Comestible , Hipersensibilidad a los Alimentos/complicaciones , Humanos , Lactante , Masculino , Ratas , Ratas Wistar , VerdurasRESUMEN
The paper deals with the results of treatment of 110 patients with advanced ovarian cancer showing signs of tumor progression following polychemotherapy with two regimens which included radiotherapy. Variants of distant and contact irradiation individually-tailored to suit the types of tumor are discussed. Details of single and repeated courses of chemoradiation are presented. Such beneficial effects as longer survival and better quality of life were registered in 76%.
Asunto(s)
Neoplasias Ováricas/patología , Neoplasias Ováricas/radioterapia , Radioterapia Asistida por Computador , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Femenino , Humanos , Persona de Mediana Edad , Estadificación de Neoplasias , Neoplasias Ováricas/tratamiento farmacológico , Neoplasias Ováricas/cirugía , Dosificación Radioterapéutica , Radioterapia Adyuvante/métodos , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
The preventive and therapeutic effects of bonnecor were shown in the experiments on awake and anesthetized rats under conditions of acute myocardial ischemia. It was concluded that the relieving influence of bonnecor on the course of acute myocardial ischemia was related to its antifibrillatory and antiarrhythmic properties.
Asunto(s)
Antiarrítmicos/uso terapéutico , Dibenzazepinas/uso terapéutico , Fibrilación Ventricular/prevención & control , Animales , Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/tratamiento farmacológico , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Masculino , Ratas , Fibrilación Ventricular/etiologíaRESUMEN
Antiarrhythmic and antifibrillation properties of bonnecor, a derivative of dibenzepin, were studied in comparison with ethmozine, quinidine and novocainamide, using various experimental arrhythmia models. Bonnecor activity was somewhat smaller than that of ethmozine, and much greater than that of quinidine and novocainamide in the mixed atrioventricular arrhythmia model simulated in aconitin-treated rats and the ventricular arrhythmia model simulated by two-degree coronary occlusion in dogs. Intravenous 1 mg/kg and oral 6 mg/kg bonnecor doses prevented ventricular fibrillation caused by acute coronary occlusion in rats, while ethmozine showed no such effect.
Asunto(s)
Antiarrítmicos/uso terapéutico , Dibenzazepinas/uso terapéutico , Aconitina/toxicidad , Animales , Antiarrítmicos/farmacología , Arritmias Cardíacas/inducido químicamente , Arritmias Cardíacas/tratamiento farmacológico , Dibenzazepinas/farmacología , Perros , Evaluación Preclínica de Medicamentos , Cobayas , Frecuencia Cardíaca/efectos de los fármacos , Técnicas In Vitro , Conejos , Ratas , Estrofantinas/toxicidad , Relación Estructura-ActividadRESUMEN
Calcium chloride (280 mg/kg intravenously) provokes arrhythmia, heart fibrillation and death of mice. Pretreatment with isoptin, etmozine, lidocaine, trimecaine, quinidine and novocainamide prevents rhythm disorders and animals' death. Isoptin, etmozine, lidocaine and trimecaine have been found the most effective. Atropine does not produce any protective action. The simplicity and availability of the method described enables one to apply it as a model for search of new antiarrhythmic drugs.