RESUMEN
Inflammatory cytokines are involved in attention deficit hyperactivity disorder (ADHD), a highly prevalent neurodevelopmental disorder. To quantify the baseline levels of pro- and anti-inflammatory cytokines and their changes after methylphenidate (MPH), a total of 31 prepubertal children with ADHD were recruited and subclassified into only two ADHD presentations-ADHD attention deficit (n = 13) or ADHD combined (n = 18). The children were also screened for oppositional defiant conduct disorder (ODCD) and anxiety disorder. Blood samples were drawn at 09:00 and after 4.63 ± 1.87 months of treatment. Four pro-inflammatory cytokines (interleukin-1beta (IL-1ß), IL-5, IL-6, tumor necrosis factor-alpha (TNF-α)) and three anti-inflammatory cytokines (IL-4, IL-10, IL-13) were measured using a Luminex® assay. For statistics, a factorial analysis was performed in Stata 15.1. Overall, there were no statistically significant differences in the interleukin (IL) values induced by treatment. When grouped by presentation, the differences were present almost exclusively in ADHD-AD, usually with a profile opposite to that observed in ADHD-C, and with interactions between comorbid factors, with IL-1ß (p = 0.01) and IL-13 (p = 0.006) being the ones reaching the greatest statistical significance. These differences are probably related to the ODCD factor, and they disappear after treatment. In conclusion, the changes observed in cytokine levels in prepubertal children only in the ADHD-AD presentation are probably related to comorbidities (specifically ODCD) and are mitigated after treatment.
RESUMEN
La terapia ocupacional supone un aspecto fundamental en la rehabilitación de cualquier paciente ingresado en una unidad hospitalaria; su uso ha demostrado aportar grandes beneficios en la recuperación de los pacientes y en su adaptación a la vida cotidiana. Entre estas actividades se encuentra la alimentación, por lo que el tratamiento de la disfagia supone un pilar fundamental en el restablecimiento de las actividades básicas de la vida diaria
Occupational therapy is a fundamental aspect in the rehabilitation of any patient admitted to a hospital unit; its use has been shown to provide great benefits in the recovery of patients and in their adaptation to daily life. Among these activities is feeding, so that the treatment of dysphagia is a fundamental pillar in the restoration of basic activities of daily living.
Asunto(s)
Humanos , Masculino , Persona de Mediana EdadRESUMEN
La diabetes mellitus constituye hoy en día una de las enfermedades con mayor presencia en la población mundial según datos de la OMS. Esta enfermedad se asocia con múltiples complicaciones ,entre las que se encuentra el pie diabético. Esta entidad afecta hasta al 50% de las personas con diabetes y está presente en alrededor del 10% en el momento del diagnóstico de dicho proceso diabeto lógico. La mayoría de las complicaciones del pie diabético tienen un origen neuropático y ,a menudo, hay una contribución vascular periférica
Diabetes mellitus is nowadays one of the most prevalent diseases in the world population according to WHO data. This disease is associated with multiple complications, among which is the diabetic foot. This entity affects up to 50% of people with diabetes and is present in about 10% at the time of diagnosis of the diabetic process. Most of the complications of diabetic foot have a neuropathic origin and there is often a peripheral vascular contribution.
Asunto(s)
HumanosRESUMEN
La debilidad neuromuscular y el deterioro funcional son cuestiones muy frecuentes en pacientes ingresados en unidades de cuidados intensivos y están íntimamente ligadas a la inmovilidad
Neuromuscular weakness and functional impairment are very common issues in patients admitted to intensive care units and are closely linked to immobility.
Asunto(s)
Humanos , Limitación de la MovilidadRESUMEN
En la actualidad, la discapacidad supone una cuestión socioeconómica difícil de abordar en todo su espectro. Se estima que en España el 6,1% de la población sufre algún tipo de discapacidad; sin embargo, según la Organización Mundial de la Salud, esta cifra es de alrededor del 15% a nivel mundial. En este sentido, es prioritario lograr un adecuado equilibrio que proporcione recursos económicos y sociales a este sector poblacional y que garantice su integración social de manera completa y equitativa.
At present, disability is a socioeconomic issue that is difficult to address in its full spectrum. It is estimated that in Spain 6.1% of the population suffers from some type of disability; however, according to the World Health Organization, this figure is around 15% worldwide. In this sense, it is a priority to achieve an adequate balance that provides economic and social resources to this sector of the population and guarantees their full and equitable social integration.