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La giardiasis es la enfermedad gastrointestinal de mayor incidencia mundial, causada por el protozoario Giardia duodenalis, para la cual no se cuenta con una vacuna o tratamiento eficiente. En aras de buscar nuevos blancos farmacológicos contra este parásito, se han estudiado las enzimas del metabolismo energético, como las sirtuinas, deacetilasas dependientes del dinucleótido de adenina y nicotinamida (NAD). Previamente se identificó a GdSir2.1 y GdSir2.2 como deacetilasas dependientes de NAD, con localizaciones subcelulares diferentes. En este trabajo se estudió otro candidato a sirtuina (GdSir2.3) mediante herramientas bioinformáticas para la identificación de características típicas de la familia sirtuina en la secuencia del candidato, y experimentales como la obtención de la proteína recombinante 6xHis-GdSir2.3 que demostró actividad deacetilasa dependiente de NAD y que sirvió como antígeno en la producción de los IgY - α -6xHis-GdSir2.3 para la localización subcelular de la proteína endógena en G. duodenalis. Lo anterior concuerda con otros estudios donde se señala a GdSir2.3 como un importante regulador de la enquistación, debido a su aumento de expresión durante esta etapa del ciclo de vida, constituyéndola como un blanco farmacológico promisorio para el control de esta parasitemia.

Giardiasis is the gastrointestinal disease with the highest incidence worldwide, caused by the protozoan Giardia duodenalis, for which there is no vaccine or efficient treatment. In order to find new pharmacological targets against this parasite, energy metabolism enzymes such as sirtuins, deacetylases dependent on the nicotinamide adenine dinucleotide (NAD), have been studied. GdSir2.1 and GdSir2.2 were previously identified as NAD-dependent deacetylases, with different subcellular locations. In this work, another candidate for sirtuin (GdSir2.3) was studied using bioinformatic tools for the identification of typical characteristics of the sirtuin family in the sequence of the candidate; and experimental ones such as obtaining the recombinant protein 6xHis-GdSir2.3 that demonstrated NAD-dependent deacetylase activity; and that it served as an antigen in the production of IgY - α - 6xHis-GdSir2.3 for the subcellular localization of the endogenous protein in G. duodenalis. The foregoing is consistent with other studies where GdSir2.3 is indicated as an important regulator of encyst due to its increased expression during this stage of the life cycle, constituting it as a promising drug target for the control of this parasitaemia.

A giardíase é a doença gastrointestinal de maior incidência no mundo, causada pelo protozoário Giardia duodenalis, para a qual não existe vacina ou tratamento eficaz. Com o objetivo de encontrar novos alvos farmacológicos contra esse parasita, têm sido estudadas enzimas do metabolismo energético, como as sirtuínas, desacetilases dependentes do dinucleotídeo adenina nicotinamida (NAD). GdSir2.1 e GdSir2.2 foram previamente identificados como desacetilases dependentes de NAD, com diferentes localizações subcelulares. Neste trabalho, outro candidato a sirtuin (GdSir2.3) foi estudado usando ferramentas de bioinformática para a identificação de características típicas da família sirtuin na sequência do candidato; e experimentais, como a obtenção da proteína recombinante 6xHis-GdSir2.3 que demonstrou atividade desacetilase dependente de NAD; e que serviu como antígeno na produção de IgY - α - 6xHis-GdSir2.3 para a localização subcelular da proteína endógena em G. duodenalis. O exposto é consistente com outros estudos em que o GdSir2.3 é apontado como um importante regulador de encisto devido à sua expressão aumentada durante esta fase do ciclo de vida, constituindo-se como um alvo promissor para o controle dessa parasitemia.

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INTRODUCCIÓN: un quiste aracnoideo es originado de la alteración de una de las membranas de la meninges (aracnoides), de predominio en la fosa craneal media; es una patología poco común que cause síntomas y si ocurren, se pueden presentar manifestaciones neuropsiquiatrías. OBJETIVO: exponer los datos clínicos; y la metodología diagnóstica y terapéutica. CASO: presentamos una paciente femenina de 24 años de edad; sin antecedentes personales médicos psiquiátricos y médicos no psiquiátricos conocidos, quien presenta una historia con un mes de evolución de síntomas psicóticos y cambios conductuales. Se le realizo CAT cerebral simple y luego una resonancia magnética cerebral contrastada para definir el tamaño del quiste aracnoideo, por los posibles síntomas neuropsiquiátricos encontrados. Por medio de exámenes de laboratorios, estudios electrofisiológicos (electroencefalograma), neuroimágenes y evaluación clínica. Se decide presentar las características clínicas encontradas de la paciente quien requirió manejo con antipsicóticos, benzodiacepinas y estabilizador del humor con gradual mejoría de sus sintomatologías de ingreso (agitación psicomotora y psicosis).

INTRODUCTION: an arachnoid cyst is caused by the alteration of one of the membranes of the meninges (arachnoid), predominantly in the middle cranial fossa; It is an uncommon pathology that causes symptoms and if they occur, neuropsychiatric manifestations may take place. OBJECTIVE: expose the clinical data; and the diagnostic and therapeutic methodology. CASE: we present a 24-year-old female patient; with no personal history of psychiatric and known non-psychiatric medical records, whom presents a story with a month of evolution of psychotic symptoms and behavioral changes. A simple cerebral CAT was performed and then a cerebral magnetic resonance imaging with contrast to define the size of the arachnoid cyst, due to the possible neuropsychiatric symptoms found. Through laboratory tests, electrophysiological studies (electroencephalogram), neuroimaging and clinical evaluation. It was decided to present the clinical characteristics of the patient who required management with antipsychotics, benzodiazepines and mood stabilizer with gradual improvement of her admission symptoms (psychomotor agitation and psychosis)

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Sheets of 5754-aluminum alloy processed by a modified repetitive corrugation and straightening (RCS) process were tested in order to measure their formability. For this purpose, forming limit curves were derived. They showed that the material forming capacity decreased after being processed by RCS. However, they kept good formability in the initial stages of the RCS process. The formability study was complemented with microstructural analysis (derivation of texture) and mechanical tests to obtain the strain-rate sensitivity. The texture analysis was done by employing X-ray diffraction, obtaining pole figures, and the orientation distribution function. It was noticed that the initial texture was conserved after successive RCS passes, but the intensity dropped. RCS process did not induce ß-fiber, contrary to common deformation process. The strain-rate sensitivity coefficient was measured through tensile tests at different temperatures and strain rates; the coefficient of the samples processed after one and two passes were still relatively high, indicating the capacity to delay necking, in agreement with the good formability observed in the initial passes of the RCS process.

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BACKGROUND: In previous studies, authors use ultrasound biomicroscopy (UBM) to analyze the characteristics of cyclitic membranes and the associated complications in patients with pars planitis. However, there are no reports regarding the prevalence of cyclitic membranes or complications at diagnosis and during follow-up. PURPOSE: To describe the characteristics and complications of cyclitic membranes, as determined by UBM in patients with pars planitis using AVISO-S™ (Quantel Medical) equipment with a 50-MHz linear probe with a focus at the pars plana. DESIGN: This retrospective study reviewed UBM images of patients diagnosed with pars planitis, from the Inflammatory Eye Disease Clinic in Mexico City from January 2010 to June 2016. RESULTS: Cyclitic membranes were observed in the first UBM image in 67 eyes (56.7%) and during follow-up in 81 eyes (68.62%). In 67 eyes (82.71%), the cyclitic membranes extended through one or two quadrants. Extension toward the posterior lens capsule was recognized in 15 eyes (18.52%) and extension toward the peripheral retina in 12 eyes (14.81%). Complications included ciliary body detachments in 10 eyes (12.35%) and peripheral retinal traction in 8 eyes (9.88%). CONCLUSIONS: UBM is a valuable tool for the diagnosis of cyclitic membranes at admittance and during follow-up of patients with pars planitis; it helps the clinician to detect this complication early.

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Mycobacterium tuberculosis strongly relies on a latency, or nonreplicating persistence, to escape a human host's immune system. The DevR (DosR), DevS (DosS), and DosT proteins are key components of this process. Like the rhizobial FixL oxygen sensor, DevS and DosT are histidine protein kinases with a heme-binding domain. Like the FixJ partner and substrate of FixL, DevR is a classical response regulator of the two-component class. When activated by DevS or DosT during hypoxia in vivo, DevR induces a dormancy regulon of more than 40 genes. To investigate the contributions of DevS, DosT, and target DNA to the phosphorylation of DevR, we developed an in vitro assay in which the full-length, sensing, DevS and DosT proteins were used to phosphorylate DevR with ATP, in the presence of target DNAs that were introduced as oligonucleotides linked to magnetic nanoparticles. We found that the DevR phosphorylations proceeded only for the deoxy states of the sensors. The reaction was strongly inhibited by O2 , but not CO or NO. The production of phospho-DevR was enhanced sixfold by target consensus DNA or acr-DNA. The phospho-DevR bound tightly to that DNA (Kd ~ 0.8 nm toward acr-DNA), and it was only slightly displaced by a 200-fold excess of unphosphorylated DevR or of a truncated DevR with only a DNA-binding domain. To our knowledge, this represents the first in vitro study of the ligand regulation of DevR phosphorylation by full-length DevS and DosT, and demonstration of a positive effect of DNA on this reaction.

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OBJECTIVE: Identify factors related to preclinical depression in healthy adults, their risk factors and concordance with family doctor diagnostic. MATERIALS AND METHODS: Case-control study in adult from family medicine consulting room. Beck inventory for depression was applied. The correlation between depression and the diagnosis by the family physician was evaluated. Odds ratio (OR) was determined. RESULTS: Involved 138 patients randomly from four family medicine units (FMU) in the Northern Region of Quintana Roo, Mexico. The mean age 34.9 ± 11.4 years, 55.8% women, prevalence for depression was 26.1%. Being male OR: 3.76; 95% CI: 1.69-8.36, under 30 years OR: 2.76; 95% CI: 1.27-5.99, low socioeconomic status (SES) OR: 2.11; 95% CI: 0.97-4.59 and be married OR: 3.22; 95% CI: 1.41.-7.36 had depression risk. Diagnosis by the family physician and inventory Beck. Kappa Index 0.2, 95% CI: -0057-0176; p = 0.05. CONCLUSIONS: Almost a third of young adults have some depression degree in family medicine consulting room, it is necessary a depression screening for male patients, low SES, married, and under 30 years old, attending medical consultation familiar, for a early diagnosis and improve prognosis.

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The aim of this study was to elucidate the effect of dietary supplementation of soybean oil (SO) and hydrogenated palm oil (HPO) on the transport of fatty acids (FA) within plasma lipoproteins in lactating and non-lactating cows. Three lactating and three non-lactating Holstein cows were used in two different 3 × 3 Latin square experiments that included three periods of 21 d. Dietary treatments for lactating cows consisted of a basal diet (control; no fat supplement) and fat-supplemented diets containing SO (500 g/d per cow) or HPO (500 g/d per cow). For non-lactating cows, dietary treatments consisted of a basal diet (control; no fat supplement) and fat-supplemented diets containing SO (170 g/d per cow) or HPO (170 g/d per cow). Compared with the control and SO diet, HPO addition increased (p < 0.05) the concentration of C16:0, C18:0, C18:2cis-9,12, C18:3cis-9,12,15 and total saturated and polyunsaturated FA in the plasma of lactating cows. In non-lactating cows, the SO addition increased the plasma concentration of C18:1trans-11. In lactating cows, concentrations of C16:0, C18:0 and total saturated FA were increased (p < 0.05) by HPO addition in the high-density lipoprotein (HDL). Total saturated FA were increased (p < 0.05) by HPO in very-low-density lipoprotein (VLDL). In non-lactating cows, the concentration of C18:0 was increased (p < 0.05) by HPO in HDL, whereas C18:1trans-11 was increased (p < 0.05) by SO in the low-density lipoprotein. Overall, it was found that distribution and transport of FA within the bovine plasma lipoproteins may be influenced by chain length and degree of unsaturation of dietary lipids. Also, the distribution of individual FA isomers such as C18:1trans-11 and C18:2cis-9,trans-11 may vary depending on the physiological state of the cow (lactating or non-lactating), and are increased in plasma (lactating cows) and the HDL (non-lactating cows) when cows are fed SO.

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TiO2 nanotube films were prepared by anodizing Ti plates in ethylene glycol based electrolytes containing variable concentrations of ammonium fluoride and water. The morphology, optical and semiconducting properties, as well as the composition of TiO2 films were shown to be dependent on the anodizing bath composition. Among different film properties, only the preferential orientation of anatase crystals, quantified with the texture coefficient of the (004) plane, TC(004), showed the same dependence of photoelectrochemical performance on the electrolyte composition. The increased value of TC(004) was related to anatase crystals piling up in the [001] direction (normal to the plane of the Ti substrate), forming a fiber like texture structure along the tube that facilitates the transport of photogenerated electrons toward the conducting substrate.

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En este artículo se analizan con parámetros de composición 58 puestas de trucha arcoiris obtenidas, manejadas y monitoreadas individualmente en desempeño desde la fertilización hasta finalizar la etapa de reabsorción de vesícula. Además de los valores reproductivos, el contenido de ácidos grasos en las ovas se determinó en fresco, mediante cromatografía de gases. En el perfil medio se destacan los ácidos palmítico (C16), oleico (C18:1n-9) y docosahexaenoico (C22:6n-3) como los más representativos, con casi el 60% del total y, en general, en concentraciones estables entre las hembras. Tanto para cada ácido determinado como para el conjunto de contenidos integrados de las series n-3 y n-6, y los colectivos de saturados (SAF), monoinsaturados (MUFA) y poliinsaturados (PUFA), se define un patrón de composición similar al reportado para la especie en otros esquemas de manejo y bajo regímenes nutricionales variables. Se analizó la condición conservativa en la incorporación de ácidos grasos al huevo, y se discutió su utilidad como posibles definitorios de calidad, teniendo como referente la alta variabilidad registrada en la supervivencia al final del proceso de incubación...

This article analyzes, with composition parameters, 58 rainbow trout egg-layings obtained, handled and monitored individually in performance from their fertilization until the end of the gallbladder reabsortion phase. Aside from the reproductive values, the content of fatty acids in the eggs was determined in fresh conditions through gas chromatography. The average profile highlights the palmitic acid (C16), oleic acid (C18:1n-9) and docosahexaenoic acid (C22:6n-3), as the most representative, with almost 60% of the total and, in general, in stable concentrations among females. Both for each determined acid and for the suite of integrated series n-3 and n-6, and the groups of saturated (SAF), monounstaturated (MUFA) and polyunsaturated (PUFA), a pattern of similar composition to the one reported is defined for the species in other management schemes and under varying nutritional regimes. The conservative condition was analyzed in the incorporation of fatty acids into the egg and its usefulness as possible quality definers was discussed, using the high variability recorded in survival at the end of the incubation process as reference...

Neste artigo analisam-se com parâmetros de composição, 58 posturas de truta arco-íris obtidas, manejadas e monitoradas individualmente em desempenho, desde a fertilização até a finalização da etapa de absorção de vesícula. Além dos valores reprodutivos, o conteúdo de ácidos graxos nas ovas foi determinado em fresco, mediante cromatografia de gases. No perfil médio destacam-se os ácidos palmíticos (C16), oleico (C18:1n-9) e docosaexaenoico (C22:6n-3), como os mais representativos, com quase 60% do total e, em geral, em concentrações estáveis entre as fêmeas. Tanto para cada ácido determinado quanto para o conjunto de conteúdos integrados das séries n-3 e n-6, e os coletivos de saturados (SAF), monoinsaturados (MUFA) e poli-insaturados (PUFA), define-se um padrão de composição similar ao relatado para a espécie em outros esquemas de manejo e em regimes nutricionais variáveis. Analisou-se a condição conservativa na incorporação de ácidos graxos à ova, e discutiu-se sua utilidade como possíveis determinantes de qualidade, tendo como referência a alta variabilidade registrada na sobrevivência ao final do processo de incubação...

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Introducción: Las fracturas de cadera en los ancianos se relacionan con diversos factores, entre los que destacan nutrición y funcionalidad. La presencia de alteraciones en el estado nutricional se ha relacionado directamente con el estado funcional. Objetivo: Determinar el estado funcional previo del paciente con fractura de cadera, el estado nutricional al momento de su ingreso y la correlación entre ambos parámetros como factores de riesgo para dicha fractura. Material y métodos: Se estudiaron 78 pacientes ancianos con fractura de cadera del 1 de febrero al 31 de diciembre de 2008. Se analizó el estado funcional y nutricional. Se utilizó estadística descriptiva y análisis inferencial mediante tablas de contingencia para pruebas de asociación con x2. Resultados: El 46,1 por ciento eran independientes funcionalmente y 53,9 por ciento presentaban deterioro funcional. El 14,1 por ciento presentaban desnutrición, 48,7 por ciento riesgo de desnutrición y 37,2 por ciento nutrición normal. Sólo el 36,7 por ciento con "problema nutricional" (MNA < 24), tenía independencia funcional (Barthel = 100), y el 62,1 por ciento con MNA > 24 era Independiente. El riesgo de dependencia se estima con un OR=2,82 (1,11- 7,19; 95 por ciento IC) con P = 0,02. Conclusiones: La independencia funcional y estado nutricional están directamente relacionados entre sí y son factores de riesgo para fractura de cadera.

Introduction: Hip fractures in elderly patients are related to several factors, among which nutrition and functionality stand out. The presence of alterations in the nutritional state has been related directly with the functional state. Objective: To determine the previous functional state of the patient with a hip fracture, the nutritional state at the moment of admittance and the correlation between both parameters as risk factors for the fracture. Materials and methods: 78 elderly patients with a hip fractured were studied from February 1st, 2009 to December 31st of 2009. The functional and nutritional stated were analyzed. Descriptive statistics and inferential analysis were used with contingency tables to test association with c2. Results: 46.1 percent were functionally independent and 53.9 percent had functional impairment. 14.1 percent presented malnourishment, 48.7 percent were at risk of malnutrition and 37.2 percent had normal nutrition. Only the 36.7 percent with the “nutritional problem” (MNA<24), had functional independence (Barthel=100), versus 62.1 percent with MNA>24 who were independent.

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Las infecciones respiratorias altas constituyen una importante causa de morbilidad en los niños menores de 5 años. Por su magnitud en la población infantil, se realizó un estudio analítico retrospectivo, de casos y controles, para determinar los factores de riesgo en las infecciones respiratorias altas recurrentes en niños menores de 5 años del Policlínico Universitario 7 de Diciembre, Jagüey Grande, Matanzas, de mayo 2008 a mayo 2009. El universo fue de 352 niños con infecciones respiratorias altas que asistieron a la consulta de Alergia; la muestra fue de 85 niños para cada grupo. Se tuvo en cuenta las variables factores sociodemográficas, y ambientales. Se determinó que la atopia, la exposición al humo del tabaco, la no lactancia materna, la ablactación incorrecta, la baja escolaridad materna, vivir en área rural, las deficientes condiciones higiénicos sanitarias como presencia de animales, viviendas viejas, mala ventilación y factores ambientales como frío, cambios de temperatura y humedad constituyen los principales factores de riesgo(AU)

The high respiratory infections are an important cause of morbidity in children aged less than 5 years old. For its magnitude among the infantile population, we carried out an analytical retrospective study of cases and controls, to determine the risk facts in the recurrent high respiratory infections in children less than 5 years old of the Teaching Policlinic 7 de Diciembre, Jaguey Grande, Matanzas, from May 2008 to May 2009. The universe were the 352 children with high respiratory infections who assisted the allergy consultation; the sample was formed by 85 children for each group. We took into account the variables socio-demographic and environmental factors. We determined that the main risk factors are the atopy, the exposition to the tobacco smoke, the lack of breastfeeding, the wrong ablactation, the low maternal scholarship, living in rural areas, the deficient hygienic-sanitary conditions like animals presence, old houses, bad ventilation and climatologic factors as cold, temperature and humidity changes(AU)

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Las infecciones respiratorias altas constituyen una importante causa de morbilidad en los niños menores de 5 años. Por su magnitud en la población infantil, se realizó un estudio analítico retrospectivo, de casos y controles, para determinar los factores de riesgo en las infecciones respiratorias altas recurrentes en niños menores de 5 años del Policlínico Universitario 7 de Diciembre, Jagüey Grande, Matanzas, de mayo 2008 a mayo 2009. El universo fue de 352 niños con infecciones respiratorias altas que asistieron a la consulta de Alergia; la muestra fue de 85 niños para cada grupo. Se tuvo en cuenta las variables factores sociodemográficas, y ambientales. Se determinó que la atopia, la exposición al humo del tabaco, la no lactancia materna, la ablactación incorrecta, la baja escolaridad materna, vivir en área rural, las deficientes condiciones higiénicos sanitarias como presencia de animales, viviendas viejas, mala ventilación y factores ambientales como frío, cambios de temperatura y humedad constituyen los principales factores de riesgo.

The high respiratory infections are an important cause of morbidity in children aged less than 5 years old. For its magnitude among the infantile population, we carried out an analytical retrospective study of cases and controls, to determine the risk facts in the recurrent high respiratory infections in children less than 5 years old of the Teaching Policlinic 7 de Diciembre, Jaguey Grande, Matanzas, from May 2008 to May 2009. The universe were the 352 children with high respiratory infections who assisted the allergy consultation; the sample was formed by 85 children for each group. We took into account the variables socio-demographic and environmental factors. We determined that the main risk factors are the atopy, the exposition to the tobacco smoke, the lack of breastfeeding, the wrong ablactation, the low maternal scholarship, living in rural areas, the deficient hygienic-sanitary conditions like animals presence, old houses, bad ventilation and climatologic factors as cold, temperature and humidity changes.

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PURPOSE: To analyze the cytotoxic effects of 2-hydroxyethylmethacrylate (HEMA) in human gingival fibroblasts using quantitative x-ray microanalysis (EXPMA) and two classical methods (DNA and LDH release in culture medium). MATERIALS AND METHODS: Different concentrations of HEMA (5, 10, 20, 30, and 40 mM) in DMEM medium were used and the effects on human gingival fibroblasts after 6, 12, and 24 h were determined. As controls, fibroblasts cultured with DMEM culture medium (negative control) and fibroblast incubated in 1% triton X (positive control) were used. RESULTS: The results showed that correlation between the concentrations of HEMA and the amount of LDH and DNA released to the medium were statistically significant for all times analyzed. LDH and DNA released from cells incubated in the lowest concentrations of HEMA (5 and 10 mM) were not significantly different to negative controls. In contrast, cells incubated in the highest HEMA concentrations (20, 30, 40 mM) showed a significant increase of both LDH and DNA released to the culture medium at 6, 12, and 24 h. On the other hand, the ionic concentration of the different elements analyzed in this work revealed that the contents of P, S, Cl, and K were significantly higher in the controls than in samples incubated for 6 h in 5 mM or 10 mM HEMA (p < 0.01). K/ Na index (an excellent marker of cell viability) showed a significant decrease, and therefore, viability was significantly reduced. CONCLUSION: The results suggest that EXPMA is a sensitive method that is able to detect early cell damage even before the cell membrane is altered.

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El leiomioma vesical es un tumor de origen mesenquimatoso y extremadamente raro. La mayoría de ellos son diagnosticados de manera casual tras el estudio patológico de las muestras remitidas tras la cirugía. Pocos son los casos presentados en la literatura, lo que nos lleva a pensar en la escasa incidencia de este tipo de tumoración. Presentamos un caso acontecido en nuestro servicio, de una paciente femenina de 18 años de edad, que acude a consulta por presentar polaquiuria, ardor y esfuerzo miccional, las exploraciones complementarias realizadas conducen a el tratamiento quirúrgico y seguimiento a que ha sido sometida la paciente(AU)

The vesical leiomyoma is a tumor of mesenchymal origin, and extremely rare. Most of them are diagnosed casually after the pathologic study of samples collected after surgery. Few cases were found in the reviewed literature, leading us to think of the scarce incidence of this kind of tumors. We present a case treated in our service, of an 18-years-old female patient, assisting to our consultation presenting a polaquiuria, ardor and mictional effort. The complementary exams led to the surgical treatment and follow up of the patient(AU)

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El leiomioma vesical es un tumor de origen mesenquimatoso y extremadamente raro. La mayoría de ellos son diagnosticados de manera casual tras el estudio patológico de las muestras remitidas tras la cirugía. Pocos son los casos presentados en la literatura, lo que nos lleva a pensar en la escasa incidencia de este tipo de tumoración. Presentamos un caso acontecido en nuestro servicio, de una paciente femenina de 18 años de edad, que acude a consulta por presentar polaquiuria, ardor y esfuerzo miccional, las exploraciones complementarias realizadas conducen a el tratamiento quirúrgico y seguimiento a que ha sido sometida la paciente.

The vesical leiomyoma is a tumor of mesenchymal origin, and extremely rare. Most of them are diagnosed casually after the pathologic study of samples collected after surgery. Few cases were found in the reviewed literature, leading us to think of the scarce incidence of this kind of tumors. We present a case treated in our service, of an 18-years-old female patient, assisting to our consultation presenting a polaquiuria, ardor and mictional effort. The complementary exams led to the surgical treatment and follow up of the patient.

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Con una incidencia variable el Thoracópagus o Toracópago es el tipo más común de gemelos unidos, representando el 75 por ciento de los casos que se reportan y son una condición rara en la cual existe predominio del sexo femenino. Se presenta el caso de gemelos unidos del tipo Toracópagos, con una fusión amplia, procedentes de la interrupción por malformaciones congénitas complejas de un embarazo múltiple en una gestante de edad avanzada, que se estudió anatómica y morfológicamente en el acto de necropsia. Aunque no existe acuerdo sobre la embriogénesis de esta malformación, la teoría más aceptada es la propuesta de que esta alteración resulta de la unión secundaria de dos discos embrionarios separados originalmente(AU)

With a variable incidence the thoracopagus is the most common type of conjoined twins representing the 75 percent of the reported cases and they show a weird condition in which females prevailed. It is presented the case of thoracopagus conjoined twins with a wide fusion coming from the interruption for complex congenital malformation of a multiple pregnancy in an aged pregnant who was anatomically and morphologically studied in the necropsy. Although there is no resolution about embryogenesis of this malformation the most accepted theory is proposal that this alteration is the result of a secondary joined of two embrionary disks initially separated(EU)

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