RESUMEN
In 16 children with malabsorption syndrome, out of which 5 had impaired lipid absorption or diarrhoea, and in 14 children in the control group the concentrations of vitamin D and 25 OH D3 were determined after oral administration of vitamin D in dose of 1200 U/kg.b.wt. or 12000 U/kg.b.wt. No decrease in initial 25 OH D3 concentrations was noted in children with malabsorption syndrome (40,5 +/- 0,7 ng/ml) in comparison with the control group (40,0 +/- 0,4 ng/ml). In children with impaired lipid absorption and diarrhoea the 25 OH D3 concentration was 33,6 +/- 2,4 ng/ml. After oral administration of vitamin D in small doses no differences were noted in the increase in vitamin D and 25 OH D3 concentrations in children with malabsorption syndrome or the control group. After administration of vitamin D in the dose 10 times higher no difference in the increase in vitamin D concentration was noted in children with malabsorption syndrome and the control group. However the increase in 25 OH D3 concentration in children with malabsorption syndrome was 49,8 +/- 1,2 ng/ml and 145,0 +/- 3,5 ng/ml in the control group. In the children with impaired lipid absorption and diarrhoea decreased vitamin D and 25 OH D3 concentrations were noted. This means that physiological doses of vitamin D in children with malabsorption syndrome are sufficient to supply vitamin D. Diarrhoea and impaired lipid absorption however, are indications for stimulation of skin synthesis of vitamin D.
Asunto(s)
Calcifediol/sangre , Síndromes de Malabsorción/sangre , Deficiencia de Vitamina D/sangre , Vitamina D/sangre , Atrofia , Niño , Diarrea/sangre , Humanos , Absorción Intestinal , Mucosa Intestinal/patología , Síndromes de Malabsorción/tratamiento farmacológico , Recurrencia , Vitamina D/uso terapéutico , Deficiencia de Vitamina D/tratamiento farmacológicoAsunto(s)
Acidosis/congénito , Acidosis/diagnóstico , Acidosis/etiología , Preescolar , Humanos , Lactante , Recién NacidoAsunto(s)
Carbohidratos de la Dieta/administración & dosificación , Glucosa/administración & dosificación , Enfermedad del Almacenamiento de Glucógeno Tipo I/dietoterapia , Preescolar , Ritmo Circadiano , Femenino , Enfermedad del Almacenamiento de Glucógeno Tipo I/metabolismo , Humanos , Infusiones Parenterales , Intubación GastrointestinalRESUMEN
Malnutrition may cause to the damage intestinal epithelium and pancreas resulting in overt signs of malabsorption syndrome. The diet protein, fats and carbohydrates stimulate secretion, CCK-P, GIP, and gastrin release and effect insulin and HGH release. The amounts of the hormones released depends on intestinal absorption and pancreas secretory function. Therefore, in undernourished children with malabsorption syndrome on impaired function of the hormonal entero-insular axis is likely. In 30 children hormonal component of malnutrition was studied. Digestion and absorption were assayed by glycemic levels and FFA, with hydroxyprolinuria studies following administration of the mixed test meal. HGH and IRI levels were measured following mixed test meal stimulation. Hormonal studies data were correlated with digestion and absorption indices. In undernourished children low levels of HGH and IRI were frequently found. In certain patients with malnutrition the administration of anabolic drugs seems to be advisable.
Asunto(s)
Dieta , Hormona del Crecimiento/sangre , Insulina/sangre , Síndromes de Malabsorción/sangre , Preescolar , Ácidos Grasos no Esterificados/sangre , Prueba de Tolerancia a la Glucosa , Humanos , Hidroxiprolina/orina , Lactante , Absorción Intestinal , Síndromes de Malabsorción/diagnóstico , XilosaAsunto(s)
Dipeptidil-Peptidasas y Tripeptidil-Peptidasas/metabolismo , Disacaridasas/metabolismo , Duodeno/enzimología , Endopeptidasas/metabolismo , Mucosa Intestinal/enzimología , Fenilcetonurias/enzimología , Atrofia , Preescolar , Duodeno/patología , Humanos , Lactante , Mucosa Intestinal/patología , Fenilcetonurias/patologíaRESUMEN
Investigations were carried out on boys aged between 8 and 20 years by positive chromatin test. Klinefelter's syndrome was confirmed by karyotype determination in 13 cases. In comparison with the average Polish population the patients' parents were older. The patients were usually the last children to be born in their families. Typical hypogonadism, cryptorchism, especially unilateral, and delay in the development of secondary sex characteristics were observed. Besides typical eunuchoid habitus, endomorphic type of body build, tendency towards obesity or sometimes even delay in growth and a deficiency in body weight were noticed. True gynaecomastia was only present in 1/4 of these patients. Very frequent features of Klinefelter's syndrome are--in the authors' opinion--mental subnormality, inadequate social adaptation and neurotic symptoms. Before adolescence the characteristic phenotype of Klinefelter's syndrome is absent. These results indicate that sex chromatin examination is a general screening test to determine Klinefelter's syndrome in boys.