RESUMEN

Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 24 experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5­88.1 µm size range, 17.8­38.9 drug content in mg/100 mg MPs and 33.1­87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.

Asunto(s)

Benzofenonas/farmacología , Química Farmacéutica/métodos , Microesferas , Protectores Solares/farmacología , Ceras/farmacología , Benzofenonas/química , Emulsiones/química , Emulsiones/farmacología , Microscopía Electrónica de Rastreo , Tamaño de la Partícula , Solubilidad , Espectrofotometría Infrarroja , Protectores Solares/química , Ceras/química