RESUMEN
The protective role of two synthetic organoselenium compounds 1-isopropyl-3-methylbenzimidazole-2-selenone (SeI) and 1, 3-di-p-methoxybenzylpyrimidine-2-selenone (Sell) was examined against the 7,12-dimethylbenz[a]anthracene (DMBA)-induced changes in biochemical parameters in blood of rats. Albino Winstar rats (150-200 g body wt) were treated with single dose of DMBA (50 mg/kg body wt) and organoselenium compounds (25 micromol/kg) for 4 weeks at two days internal. Blood was taken from the anaesthetized rats ventricle from their hearts for biochemical analysis. Administration of DMBA resulted in elevation of urea, uric acid and creatinine levels as well as AST, ALT and LDH activities and decrease in levels of total proteins, albumin and globulin. SeI and SeII caused a significant (p<0.05) decrease in urea, uric acid and creatinine levels and alanine aminotransferase (ALT); aspartate aminotransferase; (AST) and lactate dehydrogenase (LDH) activities and significantly increased the levels of total protein and albumin (p<0.05). These organoselenium compounds are likely to be beneficial in human health.
Asunto(s)
9,10-Dimetil-1,2-benzantraceno/toxicidad , Bencimidazoles/farmacología , Carcinógenos/toxicidad , Contaminantes Ambientales/toxicidad , Peroxidación de Lípido/efectos de los fármacos , Compuestos de Organoselenio/farmacología , Pirimidinas/farmacología , Animales , Proteínas Sanguíneas/análisis , Enzimas/sangre , Enzimas/orina , Ratas , Ratas WistarRESUMEN
Azolium salts and neutral 2-aryl derivatives of benzimidazole, benzothiazole and benzoxazole were synthesized and compounds were identified by 1H and 13C NMR spectroscopy and microanalytical methods. In this work the salts 1 and the neutral compounds 2 were evaluated for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals. The compounds 1f, 1g, 1l, 1m, 1n, 2a, 2b, 2c, 2e, 2f showed antimicrobial activity against Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicals, with minimum inhibitory concentrations (MICs) ranging between 50 to 200 mg/mL. Compounds 1f, 1g, 1l, lm, 2b, 2c showed the highest activity. Benzothiazolium and benzoxazolium salts were more active than 1,3-disubstituted benzimidazolium salts and neutral 2-substituted benzimidazole, benzothiazole and benzoxazole derivatives.
Asunto(s)
Antibacterianos/farmacología , Bencimidazoles/farmacología , Enterococcus faecalis/efectos de los fármacos , Escherichia coli/efectos de los fármacos , Pseudomonas aeruginosa/efectos de los fármacos , Staphylococcus aureus/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Pruebas de Sensibilidad MicrobianaRESUMEN
A new selective reagent, S,S'-bis(2-aminophenyl)oxalate (H2L), for the extractive spectrophotometric determination of copper has been prepared. The ligand, H2L, forms a 1:1 complex with copper(II) in methanol. The molar absorptivity of Cu(II)-S,S'-bis(2-aminophenyl)oxalate complex in methanol is 5365 M(-1) cm(-1) at 504 nm. The method has been applied for the determination of copper in pharmaceutical formulations, environmental and foodstuff samples.
Asunto(s)
Cobre/análisis , Oxalatos/análisis , Cobre/aislamiento & purificación , Contaminantes Ambientales/análisis , Análisis de los Alimentos , Concentración de Iones de Hidrógeno , Indicadores y Reactivos , Ligandos , Plantas/química , Reproducibilidad de los Resultados , Solventes , Espectrofotometría UltravioletaAsunto(s)
Colelitiasis/cirugía , Colecistectomía , Colelitiasis/diagnóstico por imagen , Humanos , RadiografíaRESUMEN
This article reports the case of a patient who sustained an injury of the intercostal artery after a vena subclavia aspiration with extensive haemothorax. After thoracotomy, haemostatic treatment, respiratory therapy, intensive care and a prolonged hospital stay the female patient was discharged with a clean bill of health.
Asunto(s)
Cateterismo/efectos adversos , Hemotórax/etiología , Infusiones Parenterales , Músculos Intercostales/irrigación sanguínea , Anciano , Arterias/lesiones , Diagnóstico Diferencial , Femenino , Humanos , Arteria Subclavia/lesiones , Vena Subclavia/lesionesRESUMEN
A case of an extrarenal nephroblastoma is reported which was located in the inguinal region. In the surrounding fat tissue normal ectopic glomerular and tubular structures and two more nephroblastomas were found. Therefore and because of negative clinical investigations in regarding of a renal malignant tumour the inguinal mass was thought to be the primary tumour and not a metastasis. This conclusion is important for the diagnosis and therapy.