RESUMEN

2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.

Asunto(s)

Agonistas alfa-Adrenérgicos/farmacología , Ácidos Carboxílicos/química , Imidazoles/farmacología , Agonistas de Receptores Adrenérgicos alfa 1 , Agonistas alfa-Adrenérgicos/química , Amidas/química , Ésteres/química , Imidazoles/química , Relación Estructura-Actividad