RESUMEN

The rare olean-18(19)-ene triterpenoids moradiol and moronic acid were synthesized from betulin, and their antiviral properties were investigated.

Asunto(s)

Antivirales/química , Antivirales/síntesis química , Ácido Oleanólico/análogos & derivados , Triterpenos/química , Animales , Antivirales/farmacología , Células Cultivadas , Embrión de Pollo , Fibroblastos/citología , Fibroblastos/virología , Virus de la Influenza A/metabolismo , Ácido Oleanólico/síntesis química , Ácido Oleanólico/química , Ácido Oleanólico/farmacología , Triterpenos/farmacología

RESUMEN

On the basis of high-resolution X-ray diffraction studies as well as quantum-chemical calculations of five carborane derivatives the peculiarities of electron density distribution functions have been analyzed. The data obtained permitted a deeper insight into the nature of unusual properties of the C-C bond in o-carborane and investigating intermolecular H ... H interactions in crystal. It was shown that such an approach allows estimating the values of lattice energy for the crystals of carboranes.