RESUMEN
Blunt chest trauma produces a variety of injuries. Penetrating cardiac injuries from rib fractures are extremely rare. We report the unusual case of a patient with multiple rib fractures and penetrating cardiac injury from dislocated segment of fractured VIII left rib. We did find eight patients reported in the literature having penetrating cardiac injuries from rib fractures. The clinical finding and the diagnosis of this injuries are discussed.
Asunto(s)
Lesiones Cardíacas/etiología , Fracturas de las Costillas/complicaciones , Esquí/lesiones , Heridas no Penetrantes/complicaciones , Heridas Penetrantes/etiología , Adulto , Femenino , Lesiones Cardíacas/diagnóstico por imagen , Ventrículos Cardíacos/lesiones , Humanos , Radiografía , Fracturas de las Costillas/diagnóstico por imagen , Heridas no Penetrantes/diagnóstico por imagen , Heridas Penetrantes/diagnóstico por imagenRESUMEN
Editing and alternative splicing of mRNA are posttranscriptional steps probably involved in pathophysiological aspects of epilepsy. The present study analyses the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR2 with respect to the expression of (i) editing at the R/G site and (ii) flip-flop cassettes. Nervous tissue from patients with temporal lobe epilepsy was analysed by RT-PCR followed by restriction enzyme assays. Human autoptic tissue served as control. R/G editing status: the relative amount of edited RNA was significantly increased in the hippocampal tissue, whereas no changes were found in neocortical tissues. Flip-flop expression: no significant alterations were found in relative abundance of spliced variants containing the flip exon. The increased editing at the R/G site in the hippocampal tissue of epilepsy patients may enhance responses to glutamate, resulting in a synapse operating at an increased gain.