RESUMEN
The biosynthesis of porphobilinogen by homogenates of the lungs, heart, liver, kidneys, spleen, pancreas and small intestinal tissues was studied in 77 intact and in 68 rats with marked lead poisoning. The activity of ALA dehydratase in the lungs was decreased by 40.3%, in the kidneys by 40%, in the heart by 38.2% and was normal in homogenates of the liver, pancreas and small intestine. In spleen homogenates, the activity was increased by 26.3%. Potential mechanisms of different ALA dehydratase reactions in organs tissues of rats with lead poisoning are discussed.
Asunto(s)
Ácido Aminolevulínico/metabolismo , Intoxicación por Plomo/metabolismo , Ácidos Levulínicos/metabolismo , Porfobilinógeno Sintasa/metabolismo , Porfobilinógeno/biosíntesis , Animales , Peso Corporal , Riñón/patología , Hígado/patología , Masculino , Tamaño de los Órganos , Ratas , Bazo/patologíaAsunto(s)
Infarto del Miocardio/diagnóstico , 17-Hidroxicorticoesteroides/orina , 17-Cetosteroides/orina , Enfermedad Aguda , Adulto , Anciano , Coagulación Sanguínea , Colinesterasas/sangre , Creatina Quinasa/sangre , Humanos , Lípidos/sangre , Persona de Mediana Edad , Infarto del Miocardio/sangre , Infarto del Miocardio/orina , Valores de ReferenciaRESUMEN
The capacity for porphobilinogen (PBG) biosynthesis from aminolevulinic acid (ALA) in the homogenates of the lung, heart, liver, kidney, pancreatic and small intestinal tissues of 77 albino rats was determined, and all the mentioned organs were found to be capable of PBG biosynthesis. The greatest ALA dehydratase activity was found in the tissue of the liver, then -- in the order of decreasing activity -- in the tissues of the kidneys, lungs, pancreas, small intestine, heart and spleen. On addition of lead solution to the synthesizing system a significant reduction in the activity of the enzyme was revealed in the tissue of the liver; the activity was unchanged in the kidney tissue. No changes in the toxic effect of lead were found on simultaneous addition of lead and D-penicillamine.