RESUMEN
OBJECTIVE: The aim of our study was to present the clinical alterations of CRP, LDH, neutrophil to lymphocyte ratio, platelets to lymphocyte ratio, D-dimer, blood gas analyses, vitamin D, VEGF, IL-6, IFN-γ, CD4+, CD8+) and their correlation with oxidative stress index (OSI) in hospitalized COVID-19 patients. PATIENTS AND METHODS: Oxidative stress index and clinical parameters were determined at admission and/or 7 days after hospitalization in 50 patients divided in moderate and severe group. RESULTS: In the moderate group of patients, a good correlation (R2 = 0.7400, p<0.05) was found between OSI and PLR, D-dimers and LDH at admission and after 7 days. The OSI correlated well with vitamin D, INF-γ, IL-6, CD4+, CD8+ and the absolute CD8 cell number on admission (R2=0.7635, p<0.05). Vitamin D deficiency (15.37 ng/mL ± 2.81) was observed at admission in the severe group, accompanied by increased levels of IL-6 (295.3 pg/mL ± 40.06), INF-γ (1.603 pg/mL ± 0.134), VEGF (546.8 pg/mL ± 124.2) compared to non-infected individuals. All patients had low partial pressure of oxygen, although it did not show statistically significant difference between the two groups. CONCLUSIONS: All investigated parameters were altered in both groups of patients and a good correlation between them was demonstrated.
Asunto(s)
COVID-19 , Laboratorios Clínicos , Humanos , Interleucina-6 , Estrés Oxidativo , Factor A de Crecimiento Endotelial Vascular , Vitamina D , VitaminasRESUMEN
Salt sensitive hypertension is known to be a contributing factor for the progression of kidney disease. This study was undertaken to investigate the role of excessive dietary salt on renal function and to evaluate the effect of valsartan and amlodipin given as a combination therapy on blood pressure and parameters specific to the renal function in salt loaded SHR rats. 48 male SHR rats at age of 20 weeks and body weight ranging between 270-350 g were used. SHR rats were divided into 3 groups: control group of rats -SHRC (n = 16) given tab water ad libitum and two salt treated groups in which tab water was replaced with a solution of NaCl (1%) from age of 8 weeks given ad libitum: SHRVAL+AMLO group (n = 16) where investigated drugs were administered at a dose of 10 mg/kg/ b.w. (valsartan) and 5 mg/kg/ b.w. (amlodipin) by gavage and SHR NaCl group (n = 16) that received saline in the same volume and the same time intervals as the SHRVAL+AMLO group. For a period of 12 weeks we have investigated the effect of the VAL+AMLO drug combination on systolic blood pressure (SBP), body weight and renal function tests. Salt loading with 1% solution in the SHR NaCl group has lead to significant increase of blood pressure, proteinuria and decrease in creatinine clearance. Combined treatment with AT1 receptor blocker and calcium antagonist has managed to control blood pressure and ameliorated renal damage.