RESUMEN

Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates inflammatory diseases by reducing pro-inflammatory signaling in response to peptidoglycans. However, RIP2 is widely expressed and interacts with several other proteins suggesting additional functions outside the NOD-signaling pathway. In this review, we discuss the immunological functions of RIP2 and its possible role in autoinflammation and immunity.

Asunto(s)

Enfermedades Autoinmunes/metabolismo , Inflamación/metabolismo , Proteínas Serina-Treonina Quinasas/metabolismo , Animales , Apoptosis , Enfermedades Autoinmunes/inmunología , Autoinmunidad , Humanos , Inmunidad , Inmunomodulación , Inflamación/inmunología , Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo , Peptidoglicano/inmunología , Transducción de Señal