RESUMEN
BACKGROUND: Tetrastarch can cause acute kidney injury (AKI) in humans with sepsis, but less likely to result in tissue edema than lactated Ringer's solution (LRS). OBJECTIVES: Compare effects of volume replacement (VR) with LRS and 6% tetrastarch solution (TS) on extravascular lung water (EVLW) and markers of AKI in hemorrhaged dogs. ANIMALS: Six healthy English Pointer dogs (19.7-35.3 kg). METHODS: Prospective crossover study. Animals underwent anesthesia without hemorrhage (Control). Two weeks later, dogs hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3 : 1 or 1 : 1 of shed blood, respectively. Anesthesia was maintained until 4 hour after VR for EVLW measurements derived from transpulmonary thermodilution cardiac output. Neutrophil gelatinase-associated lipocalin (NGAL) and creatinine concentrations in plasma and urine were measured until 72 hour after VR. RESULTS: The EVLW index (mL/kg) was lower at 1 hour after TS (10.0 ± 1.9) in comparison with controls (11.9 ± 3.4, P = 0.04), and at 4 hour after TS (9.7 ± 1.9) in comparison with LRS (11.8 ± 2.7, P = 0.03). Arterial oxygen partial pressure-to-inspired oxygen fraction ratio did not differ among treatments from 0.5 to 4 hour after VR. Urine NGAL/creatinine ratio did not differ among treatments and remained below threshold for AKI (120,000 pg/mg). CONCLUSIONS AND CLINICAL IMPORTANCE: Although TS causes less EVLW accumulation than LRS, neither fluid produced evidence of lung edema (impaired oxygenation). Both fluids appear not to cause AKI when used for VR after hemorrhage in healthy nonseptic dogs.
Asunto(s)
Agua Pulmonar Extravascular/efectos de los fármacos , Derivados de Hidroxietil Almidón/farmacología , Soluciones Isotónicas/farmacología , Anestésicos por Inhalación/administración & dosificación , Animales , Gasto Cardíaco/efectos de los fármacos , Creatinina/sangre , Creatinina/orina , Estudios Cruzados , Perros , Femenino , Hemorragia , Derivados de Hidroxietil Almidón/efectos adversos , Isoflurano/administración & dosificación , Soluciones Isotónicas/efectos adversos , Lipocalina 2/sangre , Lipocalina 2/orina , Masculino , Sustitutos del Plasma/efectos adversos , Sustitutos del Plasma/farmacología , Estudios Prospectivos , Lactato de RingerRESUMEN
Radiation therapy is a modality that is presenting great advances in veterinary medicine worldwide. In Brazil, this therapeutic option is underachieved. The success of this method depends on several factors, including the use of appropriate accessories for protection and immobilization of patients. For the immobilization of small animals during treatment, in addition to sedation and anesthesia, immobilizing accessories, similar to those used in human radiotherapy, are used. This study aimed to present proposals for immobilizing accessories adapted to the positioning of small animals in order to be used in radiotherapy planning. In order to achieve results, accessories were made and tested in a living animal simulating a radiotherapy planning, which proved to be favorable to use in positioning small animals undergoing radiotherapy and for implementation processes.(AU)
A radioterapia é uma modalidade que tem apresentando grandes avanços dentro da medicina veterinária pelo mundo. No Brasil, essa opção terapêutica é pouco realizada. O sucesso dessa modalidade depende de vários fatores, entre eles, o uso de acessórios adequados para a proteção e imobilização dos pacientes. Para a imobilização dos pequenos animais durante o tratamento, além da sedação e da anestesia, são utilizados acessórios imobilizadores semelhantes aos usados na radioterapia humana. Devido a isso, este trabalho teve como objetivo de apresentar propostas de acessórios de imobilização adaptados ao posicionamento de pequenos animais para o uso nos planejamentos radioterápicos. Para a sua realização, foram confeccionados acessórios e testados em um animal vivo simulando um planejamento radioterápico, os quais mostraram ser favoráveis ao uso nos posicionamento de pequenos animais submetidos à radioterapia e para sua implementação.(AU)