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Objective: Intestinal failure refers to a reduction in intestinal function that necessitates intravenous supplementation of macronutrients, water, or electrolytes due to the intestine's inability to absorb these substances adequately to maintain health and growth. This study aims to explore the experiences and challenges faced by patients enrolled in the intestinal rehabilitation program at Hospital Pablo Tobón Uribe in Medellín. Methodology: This qualitative study adopts a hermeneutic approach and utilizes grounded theory techniques. The sampling process involved both selective and theoretical sampling. A total of 20 semi-structured interviews were conducted, with eight interviews including contributions from family members. The data analysis commenced with open coding, followed by the grouping of codes into descriptive categories. Dimensions and properties were identified within these categories, and analytical categories were subsequently developed through axial and selective coding. This iterative process led to the emergence of the final paradigm matrix. Results: The study revealed that the healthcare system inadequately addresses the needs and expectations of patients with intestinal failure, leading to increased uncertainty about the disease's origin and future prognosis. Intestinal failure and its treatment disrupt various aspects of patients' lives, including personal, family, and work domains. Social stigmatization and rejection are prominent, underscoring the importance of support from family and close individuals in facilitating adaptation and revaluing life. Conclusions: Coping with the challenges of intestinal failure entails embracing the necessity of relying on parenteral nutrition, which is perceived as a prison that paradoxically enables survival.

Objetivo: la insuficiencia intestinal es la reducción de la función intestinal que requiere la suplementación intravenosa de macronutrientes, agua o electrolitos, pues el intestino no logra la absorción mínima para mantener la salud y el crecimiento. El objetivo es comprender el significado que tiene afrontar la condición de insuficiencia intestinal en pacientes que pertenecen al programa de rehabilitación intestinal del Hospital Pablo Tobón Uribe de Medellín. Metodología: estudio cualitativo con enfoque hermenéutico que utilizó técnicas de la teoría fundamentada. El muestreo fue primero selectivo y luego teórico. Se realizó un total de 20 entrevistas semiestructuradas; 8 de las cuales tuvieron el aporte de familiares. El análisis inició por la codificación abierta. Los códigos obtenidos se agruparon en categorías descriptivas, y en ellas se identificaron dimensiones y propiedades que se utilizaron para elaborar categorías analíticas mediante la codificación axial y selectiva que permitió emerger la matriz del paradigma final. Resultados: las necesidades y expectativas de los pacientes con insuficiencia intestinal no son suficientemente atendidas por el sistema de salud, lo que genera mayor incertidumbre sobre el origen de la enfermedad y aún más sobre su futuro. La insuficiencia intestinal y su tratamiento trastornan la vida personal, familiar y laboral. El rechazo social es marcado, por lo que el apoyo familiar y de las personas cercanas es fundamental para lograr la adaptación que les permite revalorar la vida. Conclusiones: afrontar la condición de insuficiencia intestinal representa la experiencia de requerir necesariamente de nutrición parenteral, la cual se percibe como una prisión que paradójicamente permite sobrevivir.

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Objective: To determine the concentration of stool short-chain fatty acids (SCFAs) in critically ill patients with sepsis and to compare the results between the critically ill patient and the control group.Methods: This descriptive, multicenter, observational study was conducted in five health institutions. Over a 6-month study period, critically ill patients with sepsis who were admitted to the intensive care unit (ICU) and met the inclusion criteria were enrolled, and a control, paired by age and sex, was recruited for each patient. A spontaneous stool sample was collected from each participant and a gas chromatograph coupled to a mass spectrometer (Agilent 7890/MSD 5975 C) was used to measure the concentrations SCFAs.Results: The final sample included 44 patients and 45 controls. There were no differences in the age and sex distributions between the groups (p > 0.05). According to body mass index (BMI), undernutrition was more prevalent among critically ill patients, and BMI in control subjects was most frequently classified as overweight (p = 0.024). Propionic acid, acetic acid, butyric acid, and isobutyric acid concentrations were significantly lower in the critically ill patient group than in the control group (p = 0.000). No association with outcome variables (complications, ICU stay, and discharge condition) was found in the patients, and patients diagnosed with infection on ICU admission showed significant decreases in butyric and isobutyric acid concentrations with respect to other diagnostic criteria (p < 0.05).Conclusions: The results confirm significantly lower concentrations of stool SCFAs in critically ill patients with sepsis than in control subjects. Due to its role in intestinal integrity, barrier function, and anti-inflammatory effect, maintaining the concentration of SCFAs may be important in the ICU care protocols of the critical patient.

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Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients.

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ABSTRACT Introduction: The treatment of acquired acrodermatitis enteropathica involves zinc supplementation; however, further research is required to establsih the optimal dose and duration of the supplementation. Case presentation: Female patient with a history of gastric bypass, intestinal resection, and 2 months of skin rash that required biopsy with histological findings compatible with dermatitis associated to nutritional deficiency. She received elemental zinc supplementation for 11 days, achieving improvement in skin lesions. She was later readmitted twice due to reactivation of the disease with the need to restart zinc supplementation. At the time of this study, she had been receiving oral elemental zinc treatment for 3 years, at doses of up to 240 mg/day. Discussion: In patients with gastric bypass and intestinal malabsorption, the usual zinc dose of 8-11 mg/day may be insufficient and put patients at risk for acquired acrodermatitis enteropathica. In similar case reports, the supplementation dose ranges from 2 mg/kg/day of venous elemental zinc to 300 mg/day orally, while the duration of supplementation has not been established. Conclusions: Oral supplementation for 3 years with a maximum dose of 240 mg/day has been adequate for controlling the disease. Monitoring blood zinc levels and physical examination of the skin have been key factors for adjusting the dose to be supplied.

RESUMEN Introducción. El tratamiento de la acrodermatitis enteropática adquirida es la suplementación de zinc, sin embargo la dosis óptima y la duración de esta aún son objeto de estudio. Presentación del caso. Paciente femenino con antecedente de bypass gástrico, resección intestinal y 2 meses de erupción cutánea que ameritó biopsia lesional con hallazgos histológicos compatibles con una dermatitis carencial. La mujer recibió suplemento de zinc elemental por 11 días, con lo que se logró mejoría de lesiones cutáneas. Posteriormente, presentó 2 reingresos por reactivación de la enfermedad con necesidad de reiniciar suplementación y, hasta el momento de la presente investigación, había permanecido 3 años con zinc elemental oral con dosis de hasta 240 mg/día. Discusión. En pacientes con malabsorción intestinal la dosis de zinc de rutina de 8-11 mg/ día puede ser insuficiente y los puede colocar en riesgo de acrodermatitis enteropática adquirida. En reportes de caso similares la dosis de suplementación va desde 2 mg/kg/día de zinc elemental venoso hasta 300 mg/día oral, en tanto la duración de la suplementación no ha sido establecida. Conclusiones. La suplementación oral por 3 años con hasta 240 mg/día ha sido adecuada para el control de la enfermedad; el seguimiento a través de la medición de los niveles de zinc en sangre y la exploración física de la piel ha sido clave en el ajuste de la dosis a suplementar.

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ABSTRACT Introduction: Refeeding syndrome (RS) is an acute metabolic disorder that occurs during nutritional repletion. Although it has been known for years, the early detection of risk factors for its onset and the implementation of measures to prevent it are not common in nutritional care. Case presentation: 48-year-old male patient, in critical care for 6 days, with suspected Wernicke-Korsakoff encephalopathy and high risk of refeeding syndrome according to criteria of the United Kingdom National Institute of Health and Clinical Excellence. The subject received enteral nutrition with 14 kcal/kg for the first 3 days, with subsequent increases aiming to achieve a nutritional goal of 25 kcal/kg on day 5. He also received daily supplementation of thiamine 600mg, folic acid 5mg and pyridoxine 50mg. Blood phosphorus decreased from 3 mg/dL to 2 mg/dL the day after initiating the nutritional plan and normalized by day 3. Discussion: The patient did not present severe hypophosphatemia or clinical manifestations of refeeding syndrome. Hypophosphatemia was resolved by maintaining a stable caloric restriction during the first days. Some professionals consider this restriction as very conservative, and others think that it may lead to achieve significant improvements in mortality reduction. Conclusions: The strategy for assessing the risk of refeeding syndrome, nutritional management and implemented follow-up were successful in preventing the patient from developing a refeeding syndrome.

RESUMEN Introducción. El síndrome de realimentación (SR) es un trastorno metabólico agudo que ocurre durante la repleción nutricional. Aunque ha sido conocido por años, la detección precoz de factores de riesgo para su desarrollo y la instauración de medidas para prevenirlo no son una práctica habitual en la atención nutricional. Presentación del caso. Paciente masculino de 48 años en cuidado crítico por 6 días, con sospecha de encefalopatía de Wernicke-Korsakoff y riesgo alto de SR según criterios del Instituto Nacional de Salud y Excelencia Clínica del Reino Unido. El sujeto recibió nutrición enteral con 14 kcal/kg los 3 primeros días, con aumentos posteriores que pretendían una meta de 25 kcal/kg al día 5 y suplementación diaria de tiamina 600mg, ácido fólico 5mg y piridoxina 50mg. El fósforo en sangre disminuyó de 3 mg/dL a 2 mg/dL al día siguiente del inicio de la nutrición y se normalizó para el día 3. Discusión. El paciente no presentó manifestaciones clínicas de SR ni hipofosfatemia severa; esta última se resolvió manteniendo estable la restricción calórica los primeros días. Para algunos profesionales dicha restricción puede ser muy conservadora; sin embargo, para otros puede llevar a mejoras significativas en la reducción de la mortalidad. Conclusiones. La estrategia para valorar el riesgo de SR, el manejo nutricional y el seguimiento implementado fueron acertados para evitar que el paciente desarrollara el síndrome.

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Resumen La calidad es considerada un factor clave en la diferenciación y en la excelencia de los servicios de salud, y la percepción de un paciente sobre la prestación del servicio determina en forma definitiva su nivel de calidad. Se han descrito indicadores que ayudan a evaluar la calidad de los servicios de salud, entre estos, indicadores de efectividad, de oportunidad y de adhesión. Sin embargo, la evaluación integral de la calidad percibida en los servicios de salud es aún compleja. Se realizó una búsqueda en Medline, Embase, OVID, Lilacs, Ebsco, Scielo y The Cochrane Library para identificar instrumentos de tipo cualitativo o cuantitativo que permitieran medir la calidad de los servicios de salud percibida por los pacientes. Se encontraron estudios que validaron y aplicaron la escala Servqual y Servqhos en el ámbito hospitalario. Adicionalmente, en nuestro país se intentó validar escalas diferentes a estas, pero no contaron con un rigor estadístico importante.

Abstract Quality is considered as a key factor for the differentiation and excellence of the health services. The way patients perceive the health care service determines conclusively the service quality levels. This work describes some indicators that help to assess the health service quality including effectiveness, opportunity, and adherence indicators. However, the comprehensive evaluation of the quality as perceived in the health services is still a complex matter. A search was conducted in the databases Medline, Embase, OVID, Lilacs, Ebsco, Scielo and The Cochrane Library in order to identify those instruments, either qualitative or quantitative, allowing to measure the health service quality as perceived by the patients. Studies were found that validated and applied the scales Servqual and Servqhos in the hospital environment. Finally, there were some attempts to validate some scales different to these ones, but they were not applied with a significant statistic rigorousness.

Resumo A qualidade é considerada fator chave na diferenciação e excelência dos serviços de saúde e a percepção de um paciente sobre a prestação do serviço determina em forma definitiva seu nível de qualidade. Indicadores que ajudam a avaliar a qualidade dos serviços de saúde já foram descritos, entre estes, indicadores de efetividade, de oportunidade e de adesão. No entanto, a avaliação integral da qualidade percebida nos serviços de saúde é ainda complexa. Realizou-se uma busca em Medline, Embase, OVID, Lilacs, Ebsco, Scielo e The Cochrane Library para identificar instrumentos de tipo qualitativo ou quantitativo que permitiram medir a qualidade dos serviços de saúde percebida pelos pacientes. Encontraram-se estudos que validaram e aplicaram a escala Servqual e Servqhos no âmbito hospitalar. Além disso, em nosso país tentou-se validar escalas diferentes a estas, mas não contamos com rigor estatístico importante.

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Introducción: entre los métodos de evaluación nutricional, se encuentra la valoración global subjetiva (VGS). La subjetividad propia de esta herramienta ha llevado a realizar adaptaciones en busca de objetivar el riesgo nutricional. Este trabajo buscó determinar la exactitud diagnóstica de una escala institucional para el cribado nutricional, propuesta por un hospital de tercer y cuarto nivel de complejidad. Materiales y métodos: estudio de corte trasversal. Se analizaron 310 pacientes, a quienes se les aplicó la VGS y la escala institucional. Se realizó el cálculo de sensibilidad, especificidad, valor predictivo positivo, valor predictivo negativo y determinación del área bajo la curva (AUC). Resultados: cuando se aplicó la VGS el riesgo de desnutrición fue 47,1% y la desnutrición 15,8%, con la escala institucional el riesgo fue 39,4% y la desnutrición 15,2%. La sensibilidad de la escala institucional para detectar el riesgo nutricional y la desnutrición fue de 75,4%, y la curva ROC indicó un valor aceptable de discriminación AUC: 0,78 (IC 95% 0,73-0,84). Conclusión: comparado con la VGS, la escala institucional es una herramienta con exactitud diagnóstica aceptable que permite detectar de manera práctica y segura el riesgo nutricional en pacientes adultos hospitalizados para derivar intervenciones terapéuticas oportunas.

Introduction: subjective global assessment (SGA) is a method included in nutritional assessment. However, it is required to make an adjustment to reduce subjectivity in nutritional risk assessment. Objective: To determine the diagnostic accuracy of an institutional scale for nutritional screening from a third/fourth level hospital. Methods: 310 patients were participated in a cross-sectional study. Each patient was evaluated by SGA and institutional scale. Diagnostic accuracy was evaluated by sensitivity, specificity, positive predictive value, negative predictive value and area under a ROC curve (AUC). Results: Undernutrition risk and undernutrition, evaluated by SGA, were 47.1% and 15.8%, respectively. In contrast, undernutrition risk and undernutrition, evaluated by the institutional scale, were respectively: 39.4% and 15.2%. Institutional scale sensitivity to detect nutritional risk and undernutrition was 75.4%. The ROC curve indicated an acceptable level of discrimination AUC: 0.78 (IC 95% 0.73-0.84). Conclusion: compared to the SGA, the institutional scale has an acceptable accuracy diagnosis to evaluate nutritional status. Thus, it is a practical and safe tool, in hospitalized adult patients, in order to indicate appropriate therapeutic interventions.

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INTRODUCTION: Obesity is held as the 21(st) Century epidemics. Multidisciplinary medical management has been insufficient and surgical techniques are more frequently used. Gastric bypass is considered the gold standard in bariatric surgery; however, some patients report low rates of weight loss, which leads to thinking about other conditioning factors. OBJECTIVE: To establish the factors associated to weight loss in a cohort of obese patients submitted to gastric bypass. METHODS: Analytical retrospective study. The study variable was weight loss, expressed as the percentage of excess body mass index lost (%EBMIL). A linear regression model of mixed effects was performed as well as a COX model of proportional risks. RESULTS: 166 patients aged 19-69 years, most of them women (74.7%), were studied. The average baseline body mass index (BMI) was 46.9 ± 6.8 kg/m(2) and 46.3 ± 7.7 kg/m(2) for males and females, respectively. The multivariate analysis showed that for each 10.0 kg/m(2) in excess at the time of surgery, the PBMIEL decreased by 9.8% and that inadequate daily caloric intake decreased the PBMIEL by 4.0%. For each 10.0 kg/m(2) of baseline BMI, there was a 57.8% decrease in the likelihood of achieving a 50% weight loss. CONCLUSIONS: The patients with lower weight excess according to their BMI have a better response to bariatric surgery in terms of PBMIEL.

Introducción: La obesidad es catalogada como la epidemia del siglo XXI. El tratamiento médico multidisciplinario no ha sido suficiente y las técnicas quirúrgicas son empleadas con mayor frecuencia. El bypass gástrico es considerado el gold standard de la cirugía bariátrica, sin embargo, algunos pacientes reportan bajas tasas de pérdida de peso, lo que hace pensar en otros factores condicionantes. Objetivo: Establecer los factores asociados con la pérdida de peso, en una cohorte de pacientes obesos sometidos a bypass gástrico. Métodos: Estudio analítico retrospectivo. La variable respuesta fue la pérdida de peso, expresada en porcentaje del exceso de índice de masa corporal perdido (PEIMCP). Se realizó un modelo de regresión lineal de efectos mixtos y un modelo de riesgos proporcionales de COX. Resultados: Se estudiaron 166 pacientes entre 19 y 69 años, la mayoría mujeres (74,7%). Los hombres presentaron un índice de masa corporal (IMC) inicial promedio de 46,9 ± 6,8 kg/m2 y las mujeres de 46,3 ± 7,7 kg/m2. El análisis multivariado mostró que por cada 10,0 kg/m2 de mas al momento de la cirugía, disminuyó el PEIMCP en un 9,8% y un inadecuado consumo calórico diario disminuyó en un 4,0% el PEIMCP. Por cada 10,0 kg/m2 de IMC inicial, hubo una disminución del 57,8% en la probabilidad de lograr una pérdida de peso del 50%. Conclusiones: Los pacientes con menor exceso de peso según su índice IMC responden mejor a la cirugía bariátrica en términos del PEIMCP.

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Objetivo Determinar los perfiles del estado de salud de las personas de 6 a 69 años de la región central Colombiana, participantes de la Encuesta Nacional de Salud, 2007. Métodos En la Encuesta participaron 18 683 personas entre 6 y 69 años de la región central Colombiana. Se calcularon estadísticas descriptivas y se realizó un análisis de correspondencias múltiples por subregión. Las variables significativas (t-test ≤0.05) para la construcción de los ejes factoriales en el plano cartesiano fueron: sexo, edad, escolaridad, área de residencia, grupo étnico, reporte de eventos mórbidos y auto-percepción de salud. Resultados Se identificaron tres tipologías del estado salud: auto percepción de salud en correspondencia con características sociodemográficas, reporte o no de eventos mórbidos y subregión de análisis. Las personas en actividades laborales o académicas reportaron mejores percepciones de salud. Para indígenas residentes en zonas rurales se encontró mayor reporte de lesiones por accidente o violencia, envenenamiento e intoxicaciones que para personas blancas de zonas urbanas; las mujeres sin educación tuvieron valoraciones más negativas del estado de salud. Se encontró, además, correspondencia entre un perfil específico de salud para cada subregión en estudio. Conclusiones Las diferencias encontradas pudieran deberse al auto-cuidado, al acceso a los servicios sociales, a la accesibilidad geográfica y a patrones culturales de reporte de la auto-percepción de salud.

Objective Determining perceived health status profiles for people aged 6 to 69 years old from the central region of Colombia, based on the 2007 National Health Survey. Method The survey involved 18,683 people aged 6 to 69 years old from the central region of Colombia. Descriptive statistics and multiple correspondence analyses by sub-region were calculated. Significant variables (≤0.05 t-test) for constructing Cartesian plane factor axes were gender, age, educational level, residential area, ethnicity, morbid event reporting and self-perceived health status. Results Three health status typologies were identified: perceived health corresponding to socio-demographic characteristics, morbid event reporting and residential area. People having a job or engaging in academic activities had better health status perception. Indigenous people living in rural areas reported injuries arising from an accident, violence and/or poisoning more frequently than white people living in urban areas. An educated woman had a more negative evaluation of their health status. Agreement was also found for a specific health profile and each sub-region being studied. Conclusions Differences may have been due to self-care, social service access, geographic accessibility and cultural patterns regarding self-reported health status perception. Analyzing greater depth is needed.

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OBJECTIVE: Determining perceived health status profiles for people aged 6 to 69 years old from the central region of Colombia, based on the 2007 National Health Survey. METHOD: The survey involved 18,683 people aged 6 to 69 years old from the central region of Colombia. Descriptive statistics and multiple correspondence analyses by sub-region were calculated. Significant variables (≤ 0.05 t-test) for constructing Cartesian plane factor axes were gender, age, educational level, residential area, ethnicity, morbid event reporting and self-perceived health status. RESULTS: Three health status typologies were identified: perceived health corresponding to socio-demographic characteristics, morbid event reporting and residential area. People having a job or engaging in academic activities had better health status perception. Indigenous people living in rural areas reported injuries arising from an accident, violence and/or poisoning more frequently than white people living in urban areas. An educated woman had a more negative evaluation of their health status. Agreement was also found for a specific health profile and each sub-region being studied. CONCLUSIONS: Differences may have been due to self-care, social service access, geographic accessibility and cultural patterns regarding self-reported health status perception. Analyzing greater depth is needed.

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Objetivo: establecer la composición de la canasta básica de alimentos real, el hábito de compra y el costo de los productos no alimentarios en hogares beneficiarios de la Fundación Ximena Rico Llano de Medellín-Colombia, en el año 2007. Materiales y métodos: estudio transversal en una muestra representativa y aleatoria de 91 hogares de la Fundación. Se aplicó una encuesta estructurada que permitió definir la canasta básica de alimentos real a partir de la disponibilidad mensual de alimentos y la determinación del hábito de compra, volumen de compra, costo, aporte de energía y aporte de proteínas provenientes de los productos alimentarios. Adicionalmente se definió la disponibilidad y costos de los productos no alimentarios adquiridos en los hogares. Resultados: la canasta básica de alimentos estuvo constituida en promedio por 30 alimentos distribuidos en doce grupos; sin embargo 16% de las familias no disponía en su canasta básica de alimentos como carne y vísceras, sustitutos de la carne, leguminosas, lácteos, bebidas, frutas y verduras. El costo de la canasta básica de alimentos fue de $448.623 (US$216), equivalente a 1,03 salarios mínimos mensuales legales vigentes. El costo de los productos no alimenticios equivalía al 14,03% del gasto mensual de los hogares en la canasta. Conclusiones: la canasta básica de alimentos de los hogares de la Fundación Ximena Rico Llano estuvo conformada por 30 alimentos, presentando poca variedad en la compra y comprometiendo el aporte nutricional de la dieta. La adquisición de productos no alimentarios (artículos para aseo personal y del hogar) representa un rubro importante dentro de los gastos mensuales, lo que puede comprometer la compra de alimentos.

Objective: to determine in the households receiving benefits from Ximena Rico Llano foundation Medellin-Colombia, the composition of consumed food, what foods these families use to buy and the cost for no nutritious food. Materials and methods: cross sectional study. Randomized and representative sample of 91 families from the foundation were selected. An structured survey was applied to define the basic foods consumed according the accessibility and to determine what type and how much food families buy, and also the cost, calories and proteins content of these foods. Moreover the cost and the accessibility for no nutritious food were also identified. Results: the basic meals consumed for families were represented for 30 aliments distributed in 12 groups; however 16% of the families didn’t have access to staple food like meat, legumes, dairy products, fruits and vegetables. The cost of the basic food was about $448.623 (US$216), it was the equivalent to 1,03 basic wage. The cost for no nutritious food represented 14% of the total Money spending in food per month. Conclusions: the basic foods of the families from Ximena Rico Llano Foundation consisted of 30 aliments, and no variety was observed. These families didn’t meet the nutritional requirements. Acquisition of products different to food represented another important investments that restrain families to spent more in staple food.

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El enfermo crítico es especialmente susceptible a déficit de nutrientes, puesto que la condición hipermetabólica del mismo, activa una serie de procesos que llevan a la disminución plasmática de ciertos nutrientes y a un aumento de los requerimientos nutricionales, los cuales muchas veces, no se cubren con el aporte de la nutrición estándar suministrada. Uno de los nutrientes cuya concentración se ve disminuida, es el selenio, un importante elemento traza, indispensable para la formación de las selenoproteínas que son compuestos responsables de una potente acción antioxidante en el organismo. El presente artículo de revisión, señala que para lograr aumentar los niveles de selenio, la suplementación de este nutriente ha sido considerada en múltiples ensayos clínicos cuyo objetivo ha sido indagar el rol y eficacia del selenio en patologías como sepsis, quemaduras y trauma. Hasta el momento, las investigaciones no han sido suficientes para responder interrogantes como la cantidad y tiempo de duración requeridas en la suplementación, lo cual señala que la evidencia no es aún suficiente para la práctica de la suplementación con selenio en este tipo de pacientes.

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