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Liquid-phase exfoliation is a technique capable of producing large quantities of two-dimensional materials in suspension. Despite many efforts in the optimization of the exfoliation process itself, not much has been done towards the integration of liquid-phase-exfoliated materials in working solid-state devices. In this article, we use dielectrophoresis to direct the assembly of liquid-phase-exfoliated TiS3 nanoribbons between two gold electrodes to produce photodetectors working in the visible region. Through electrical and optical measurements we characterize the responsivity of the device and we find values as large as 3.8 mA W-1, which are more than one order of magnitude higher compared to state-of-the-art devices based on liquid-phase-exfoliated two-dimensional materials assembled by drop-casting or ink-jet methods.

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The autocorrelation function of the fluorescence intensity of a nanoemitter is measured with the standard Hanbury-Brown and Twiss setup. Time-tagging of the photodetection events during all the experiment has opened new possibilities in terms of post-selection techniques that enable to go beyond the blinking and antibunching characterization. Here, we first present a new method developed to investigate in detail the antibunching of a fluorophore switching between two emitting states. Even if they exhibit the same fluorescence intensity, their respective amount of antibunching can be measured using the gap between their respective decay rates. The method is then applied to a nanoemitter consisting in a colloidal quantum dot coupled to a plasmonic resonator. The relative quantum efficiency of the charged and neutral biexcitons are determined.

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The use of intravenous immunoglobulin (IgIV) increased in the last ten years. IgIV are used in three different groups of haematologic pathologies. The first group is formed by the immunodeficiencies: primaries (those that started the use of IgIV) and secondaries (from immunosuppressive agents and from deficit accessories of Ig). The second group is that of autoimmunity of the blood corpuscular elements (ITP, autoimmune neutrocytopenia and autoimmune haemolytic anaemias). The third group is represented by thrombotic thrombocytopenic purpura. The right protocol and the optimal formulas of the dosages of IgIV are still to be tested. The same applies to its action mechanisms and its potential utilization in other diseases.

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Radioisotopic study of platelet kinetics can provide a preliminary orientation in the diagnosis of thrombocytopenia. A study of the platelet kinetics in thrombocytopenic and normal subjects using the Cr51 isologous platelet labelling technique and subsequent in vivo injection of the labelled platelets was conducted. The results obtained confirm the reliability and usefulness of the technique. The identification of the limitations involved and the recognition of their significance in processing data allows the hematologist and the general practitioner to allow the right amount of room for the study of platelet kinetics in the diagnosis of thrombocytopenia.

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The report attempts to show why therapeutic success in the treatment of Hodgkin's disease levelled off at the start of the Eighties. The prospects of future treatment based on more accurate interpretation of clinical and histopathological data, further cytological and immunological research as well as improved therapeutic techniques more carefully adapted to the variety of prognoses are also discussed.

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One hundred-forty-five postmenopausal women with metastatic breast cancer entered a prospective randomized trial comparing treatment A (cyclophosphamide, methotrexate, and 5-fluorouracil; CMF) with treatment B (the same chemotherapy plus tamoxifen; CMF plus T). Patients on treatment A had T added to CMF at the time of progression or relapse (second-line CMF plus T). One hundred thirty-three cases were evaluable. Considering response rate to first-line treatment, CMF plus T appeared to be significantly superior to CMF alone (74 versus 51%, respectively; P less than 0.01). Median time to failure to first-line treatments, considering all patients, was longer in CMF plus T than in CMF arm (48 and 24 weeks, respectively; P = 0.06). Considering patients showing objective remission, median duration of response to CMF was similar to that of CMF plus T (47 and 51 weeks, respectively). Twelve of 39 evaluable women treated with second-line CMF plus T showed objective responses (31%). Median time to failure to treatment procedures scheduled in arm A (CMF leads to CMF + T) was longer than that to treatment in arm B (CMF plus T) (56 and 48 weeks, respectively; P = 0.08). Median survival was longer in patients randomized to treatment A (111 weeks) than in patients randomized to treatment B (78 weeks), but this difference was not statistically significant (P = 0.25). It can be concluded from this study that a combination of endocrine therapy and chemotherapy is significantly more active than chemotherapy alone in inducing an objective remission. This strategy of treatment is advisable in situations urgently requiring a clinical response. However, as a sequence of chemical and endocrine therapy induced a longer time to development of progressive disease and a better survival, sequential therapy is advisable for common clinical use.

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An assessment was made of the importance of certain laboratory data as diagnostic and prognostic parameters in 34 cases of Hodgkin and non-Hodgkin lymphoma. The results of other workers are referred to by way of comparison.

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56 cases of myeloma observed since 1956 are reviewed and it is noted that course, prognosis and survival have changed in relation to the improvement in diagnostic procedures and therapeutic aids. The recent introduction of polychemotherapeutic approaches based on theoretical considerations has not yet been fully vetted in the clinic although a higher percentage of remissions compared to that obtained by monochemotherapy would seem to be confirmed. Personal experience with a new polychemotherapeutic schema in advanced myeloma resistant to monochemotherapy + prednisone is reported.

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The relation between granulocyte turnover, as shown by serum lysozyme values, and the marrow granulocyte reserve, evaluated by means of the hydrocortisone test, was determined in 20 patients with metastasised solid tumours or lymphomas undergoing cytostatic and/or radiation management. In addition to confirming the validity of this test as a means of assessing the behaviour of the marrow storage compartment, it pointed to a correlation between the hydrocortisone test and serum lysozyme. High enzyme values, in fact, insofar as they are an expression of accelerated granulocyte turnover may be seen as an indication of reduced marrow function, and thus offer a simple means of predicting reduction of the marrow granulocyte reserve, and hence a possible post-chemotherapeutic leukopenia, in some cases where peripheral leukopenia is not apparent.

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On the basis of a personal observation, the cases of "non secretory" multiple myeloma reported in the literature are reviewed. A myeloma classification based upon the production and excretion of monoclonal proteins by neoplastic plasmacells is presented together with an evaluation of the different possible pathogenetic mechanisms. The diagnostic criteria of "non secretory" myeloma are discussed and its main clinical problems analyzed.

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