Asunto(s)
Vagina/microbiología , Enfermedades Vaginales/diagnóstico , Enfermedades Vaginales/patología , Infecciones por Bacteroidaceae/diagnóstico , Infecciones por Bacteroidaceae/microbiología , Candida/aislamiento & purificación , Candidiasis/diagnóstico , Candidiasis/microbiología , Corynebacterium diphtheriae/aislamiento & purificación , Femenino , Bacterias Grampositivas/aislamiento & purificación , Humanos , Mobiluncus/aislamiento & purificación , Enfermedades Vaginales/etiología , Enfermedades Vaginales/microbiologíaAsunto(s)
Infecciones Bacterianas/diagnóstico , Infecciones Bacterianas/tratamiento farmacológico , Técnicas Bacteriológicas/métodos , Vagina/microbiología , Infecciones Bacterianas/microbiología , Candidiasis Vulvovaginal/diagnóstico , Candidiasis Vulvovaginal/tratamiento farmacológico , Candidiasis Vulvovaginal/microbiología , Femenino , Humanos , Infecciones por Mycoplasma/diagnóstico , Infecciones por Mycoplasma/tratamiento farmacológico , Infecciones por Mycoplasma/microbiología , Vaginosis Bacteriana/diagnóstico , Vaginosis Bacteriana/tratamiento farmacológico , Vaginosis Bacteriana/microbiologíaRESUMEN
The histo- and ultrastructure of the murine kidney and liver is studied 17 and 48 h, respectively, after unilateral nephrectomy or partial hepatectomy. The number of lymphocytes are found to be increased in these organs after the operation. They come in close contact with hepatocytes and renal tubular epithelial cells forming in some cases gap junctions. It occurs more often 48 h after operation. The number of leukocytes is found to be increased also especially in the regenerating liver in which many hepatocytes with cytoplasm partial necrosis are found. Only single epithelial cells are involved in the destruction in the kidney. Possibility of lymphocyte participation in the morphogenetic function realization is discussed.
Asunto(s)
Riñón/fisiología , Regeneración Hepática , Regeneración , Animales , Comunicación Celular , Hepatectomía , Riñón/patología , Linfocitos/patología , Masculino , Ratones , Ratones Endogámicos CBA , NefrectomíaAsunto(s)
Hígado/citología , Bazo/citología , Animales , Pollos , Hepatectomía , Masculino , Nefrectomía , Pancreatectomía , Rana temporaria , Linfocitos T/citologíaRESUMEN
Histostructure of the thymus and spleen was studied after a sham operation, unilateral nephrectomy and 2/3 hepatectomy. The alterations observed corresponded to those in stress. The differences were seen in intensity and changes in the spleen periarterial zones. These zones were wasted 4-72 hours after the sham operation while their cellularity was increasing after nephrectomy and hepatectomy. The structure of the thymus got partially restored by day 5-7, while blast transformation and plasmatization of splenic cells was not yet completed.
Asunto(s)
Hepatectomía/efectos adversos , Nefrectomía/efectos adversos , Bazo/patología , Timo/patología , Animales , Ratones , Ratones Endogámicos , Bazo/irrigación sanguínea , Estrés Fisiológico/patologíaRESUMEN
The influence of unilateral nephrectomy on the degree of humoral immune response to T-independent (polyvinylpyrrolidone, PVP) and T-dependent (sheep red blood cells, SRBC) antigens was studied. The increase in the number in antibody-forming cells (AFC) and nonspecific immunoglobulin-forming cells (nIFC) was investigated by means of the adaptive transfer model. The lethally irradiated recipients were injected with the antigen and also the spleen cells of operated and intact donors. PVP did not induce significant alterations of antibody genesis in mice receiving spleen cells of unilaterally nephrectomized animals comparing with recipients of intact spleen cells. At the same time, the kidney operation induced the increase in the number of AFC and nIFC when the SRBC were used. Hence the activation of humoral immune response induced by kidney operation was related not to the direct activation of B-lymphocytes but to T-cells. The possible causes of this activation were analyzed. Spleen cells of operated animals enhance both specific and antigen-dependent nonspecific immune response.
Asunto(s)
Anticuerpos/análisis , Antígenos T-Independientes/inmunología , Riñón/inmunología , Animales , Formación de Anticuerpos/efectos de los fármacos , Eritrocitos/inmunología , Inmunidad Innata/efectos de los fármacos , Inmunización Pasiva , Riñón/efectos de los fármacos , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Nefrectomía , Povidona/inmunología , Bazo/inmunologíaRESUMEN
The ability of spleen cells to respond with antibody formation to a foreign antigen (sheep erythrocytes) was studied in mice at different kidney lesions (uni- and bilateral nephrectomy, ureter ligation, pseudo-operation, wound of one kidney) during the early postoperation period (1-72 h). In the case of bilateral nephrectomy, the reliable increase in the number of antibody-forming cells (AFC) was noted already within 1 h after the operation, in the case of unilateral nephrectomy within 12 h. In the case of bi- and unilateral ligations of ureter, the response was delayed by 3 and 5 h, respectively. Sham operation and kidney wound did not stimulate antibody formation. It is suggested that the antibody-forming ability of the spleen cells does not depend on stress, renal deficiency or destructive changes and that the antibody formation is activated by disturbances in the ratio of immunoregulatory cells.
Asunto(s)
Formación de Anticuerpos , Fallo Renal Crónico/inmunología , Riñón/inmunología , Regeneración , Animales , Células Productoras de Anticuerpos/inmunología , Eritrocitos/inmunología , Inmunización , Riñón/lesiones , Riñón/fisiología , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Nefrectomía , Bazo/inmunología , Factores de TiempoRESUMEN
The ability of C57BL/6 mouse splenocytes to induce regional GVHR during uni- and bilateral nephrectomy, ligation of the ureter and sham operations was studied. It was shown that any kidney operation enhances the ability of splenocytes to induce the GVHR in contrast to uni- and bilateral sham operations. This phenomenon was first observed during bilateral nephrectomy (after 5 h), unilateral nephrectomy (after 24 h) and ligation of the ureter (after 72 h). The data indicate that deficiency of the tissue is the main cause of changes in the immunity system status rather than changes in antigen properties and functional insufficiency of the kidneys.