RESUMEN
Open-source APOST-3D software features a large number of wavefunction analysis tools developed over the past 20 years, aiming at connecting classical chemical concepts with the electronic structure of molecules. APOST-3D relies on the identification of the atom in the molecule (AIM), and several analysis tools are implemented in the most general way so that they can be used in combination with any chosen AIM. Several Hilbert-space and real-space (fuzzy atom) AIM definitions are implemented. In general, global quantities are decomposed into one- and two-center terms, which can also be further grouped into fragment contributions. Real-space AIM methods involve numerical integrations, which are particularly costly for energy decomposition schemes. The current version of APOST-3D features several strategies to minimize numerical error and improve task parallelization. In addition to conventional population analysis of the density and other scalar fields, APOST-3D implements different schemes for oxidation state assignment (effective oxidation state and oxidation states localized orbitals), molecular energy decomposition schemes, and local spin analysis. The APOST-3D platform offers a user-friendly interface and a comprehensive suite of state-of-the-art tools to bridge the gap between theory and experiment, representing a valuable resource for both seasoned computational chemists and researchers with a focus on experimental work. We provide an overview of the code structure and its capabilities, together with illustrative examples.
RESUMEN
Ulipristal acetate (UPA) is a medical therapy for patients with symptomatic uterine fibroids. The drug has shown efficacy in the control of heavy menstrual bleeding and, as a consequence, in anaemia improvement. We report the case of a hypertensive patient treated with two courses of UPA. In addition to its observed benefits on hypermenorrhea caused by uterine fibroids, no exacerbation of the underlying disease was observed. No adverse effects were observed, and blood pressure levels were well controlled throughout.
RESUMEN
Objetivos: Considerar los beneficios de lamiomectomía laparoscópica (ML) frente a la laparotómica (MA) y establecer los límites de su indicación. Material y métodos: Se estudia de manera retrospectiva los casos de MA (210) y ML (128) entre los años 2002 y 2006. Asimismo, se analiza el seguimiento postoperatorio (complicaciones, días de ingreso, pérdida hemática) y la tasa de embarazo según la técnica quirúrgica utilizada. Resultados: Se realizaron 338 miomectomías, 210 (62,1%) MA y 128 (37,9%) ML. Al analizar ambastécnicas sólo el número de miomas, tamaño, el tiempo quirúrgico utilizado, los días de ingreso y la tasa de complicaciones presentaban diferencias estadísticamente significativas. El porcentaje de embarazo en ambos grupos fue del 14,1% (18 casos) en la ML y del 16,3% (34 casos) en la MA. Conclusiones: La ML requiere mayor tiempo quirúrgico pero permite una mejor recuperación postoperatoria, menor estancia hospitalaria, menos adherencias, menor pérdida hemática e igual tasa de embarazo que la laparotomía
Objectives: To analyze the benefits oflaparoscopic myomectomy (LM) versus openmyomectomy (OM) and to assess the limits of itsindications.Material and methods: Data from 210 OM and128 LM performed between 2002 and 2006 wereretrospectively analyzed. Postoperative follow-up(complications, length of stay, blood loss) and thepregnancy rate according to the surgical procedurewere also analyzed.Results: We performed 338 myomectomies,210 OM (62.1%) and 128 LM (37.9%). Analysis of both techniques revealed that only myoma size,myoma number, operating time, length of hospitalstay and the complications rate showed statisticallysignificant differences. The pregnancy rate was14.1% (18 patients) in LM and 16.3% (34 patients)in OM.Conclusions: LM requires longer operating timebut speeds recovery, reduces length of hospital stayand produces fewer adhesions and less blood lossthan OM. The pregnancy rate is similar with bothprocedures