RESUMEN
PURPOSE OF REVIEW: The use of recreational drugs has increased globally, with the most commonly used recreational drug being cannabis. As of 2019, 10 states and the District of Columbia have legalized cannabis for recreational use, with more states potentially joining this movement. With the increased legalization of cannabis, leading to even greater recreational and medicinal use, it is important to recognize its effect on cardiovascular health. We propose to review the current literature regarding the pathophysiology of endocannabinoids, their hemodynamic effects, and their association with acute and chronic cardiovascular outcomes. RECENT FINDINGS: The demonstrated effects of the endocannabinoid system on the cardiovascular system at the cellular level have led to great interest regarding its potential clinical impact. A number of studies have attempted to characterize the hemodynamic effects of cannabis use as well as its potential negative impact on the cardiovascular system, but the data are inconclusive at this time. The largest prospective study to date, the CARDIA study, failed to show an association between lifetime or recent cannabis use and cardiovascular events. There is suggestion on a molecular level and based on retrospective analyses that cannabis may have a negative impact on the cardiovascular system. However, prospective clinical data has not confirmed these suggested findings. Further research is needed to better elucidate the association, if any, between cannabis and cardiovascular disease.
Asunto(s)
Cannabis/efectos adversos , Enfermedades Cardiovasculares/fisiopatología , Sistema Cardiovascular/efectos de los fármacos , Adolescente , Adulto , Cannabis/química , Dronabinol/sangre , Dronabinol/farmacología , Endocannabinoides/metabolismo , Femenino , Humanos , Legislación de Medicamentos , Masculino , Fumar Marihuana/efectos adversos , Persona de Mediana Edad , Receptor Cannabinoide CB1/metabolismo , Receptor Cannabinoide CB2/metabolismo , Adulto JovenRESUMEN
Phytoextraction has shown great potential as an alternative technique for the remediation of metal contaminated soils. The objective of this study was to investigate cadmium (Cd) phytoextraction ability of high biomass producing weeds in comparison to indicator plant species. The pot study conducted with 10 to 200 mg Cd kg(-1) soil indicated that Ipomoea carnea was more effective in removing Cd from soil than Brassica juncea. Among the five species, B. juncea accumulated maximum Cd, but I. carnea followed by Dhatura innoxia and Phragmytes karka were the most suitable species for phytoextraction of cadmium from soil, if the whole plant or above ground biomass is harvested. In the relatively short time of this experiment, I. carnea produced more than 5 times more biomass in comparison to B. juncea. There were significant differences (p < 0.05) between the shoot length and shoot mass of control and treated plants.