RESUMEN
Cytogenetic activity of 7 pesticides from various chemical classes was studied on mice bone marrow cells. 6 substances produced a mutagenic effect of different degrees of severity. The dependence of cytogenetic activity on the path, duration of administration into the organism and terms of cell fixation was stated. Hygienic standards and regulations for the production and use of the studied pesticides were developed with regard for the data obtained. The mutagenic effect appeared to be a limiting criterion of harmfulness for 2 substances in the substantiation of their MACs in the air of occupational area.
Asunto(s)
Médula Ósea/efectos de los fármacos , Aberraciones Cromosómicas/genética , Insecticidas/toxicidad , Mutación , Compuestos Organofosforados , Ácidos Ftálicos/toxicidad , Administración por Inhalación , Administración Oral , Animales , Médula Ósea/ultraestructura , Citogenética , Herbicidas , Insecticidas/administración & dosificación , Insecticidas/normas , Masculino , Concentración Máxima Admisible , Ratones , Mutágenos , Ácidos Ftálicos/administración & dosificación , Ácidos Ftálicos/normasRESUMEN
Pesticide hexachlorobutadiene (HCBD) has been studied for its mutagenic activity in two test systems: in vivo and in vitro. The above pesticide manifested a mutagenic activity in the bone marrow cells under peroral and inhalation effect. No clastogenic action in the human peripheral lymphocyte culture was observed. Results of this study and data available in literature permit concluding that HCBD is an indirect mutagen.
Asunto(s)
Butadienos/farmacología , Fungicidas Industriales/farmacología , Mutágenos/farmacología , Animales , Médula Ósea/efectos de los fármacos , Médula Ósea/ultraestructura , Células Cultivadas , Aberraciones Cromosómicas , Humanos , Linfocitos/efectos de los fármacos , Linfocitos/ultraestructura , Masculino , RatonesRESUMEN
The paper deals with the primary principle of potential mutagenic pesticides hazard evaluation from the results of study on their cytogenetic activity in experimental animals. This evaluation may be based on two main parameters characterizing a mutagenic property of pesticides--the degree of maximum cytogenetic effect expression and the level of minimum effective dose. According to the suggested principle 22 pesticides under study are distributed into some groups in conformity with the degree of their potential mutagenic hazard.