RESUMEN
Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal.
Asunto(s)
Antifúngicos/aislamiento & purificación , Fosforilcolina/análogos & derivados , Plantas Medicinales/química , Antifúngicos/farmacología , Aspergillus fumigatus/efectos de los fármacos , Candida albicans/efectos de los fármacos , América Central , Cryptococcus neoformans/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Fosforilcolina/aislamiento & purificación , Fosforilcolina/farmacología , América del SurRESUMEN
Foraging in trees by the Argentine ant,Iridomyrmex humilis (Mayr), was disrupted by a variety of synthetic chemicals, with the most effective chemical being farnesol. Testing of substrates for presentation of the disruptant chemicals gave some success with rubber or Tygon tubing, although best results were obtained through incorporation of the material into Stikem, which was then banded around tree trunks. Amounts of farnesol used for effective, long residual ant control were between 0.8 and 2 g per tree.