RESUMEN

Two new cembrane diterpenoids, named populeuphrines A and B (1 and 2), together with three known analogues (3-5) were isolated from the resins of Populus euphratica. The planar structures and relative configurations of 1 and 2 were elucidated by detailed 1 D and 2 D NMR spectroscopic analyses. The absolute configurations of 1 and 2 were determined by X-ray diffraction analysis and quantum chemical computation. Biological activities of all the isolates against proliferation of human cancer cells and umbilical cord mesenchymal stem cells were evaluated.

Asunto(s)

Diterpenos/química , Diterpenos/farmacología , Populus/química , Resinas de Plantas/química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Cristalografía por Rayos X , Diterpenos/aislamiento & purificación , Sangre Fetal/citología , Humanos , Espectroscopía de Resonancia Magnética , Células Madre Mesenquimatosas/efectos de los fármacos , Estructura Molecular