RESUMEN

We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.

Asunto(s)

Adiponectina/biosíntesis , Arildialquilfosfatasa/biosíntesis , Diabetes Mellitus Tipo 2/diagnóstico , Proteínas del Ojo/biosíntesis , Regulación de la Expresión Génica , Factores de Crecimiento Nervioso/biosíntesis , Retina/patología , Serpinas/biosíntesis , Donantes de Tejidos , Adiponectina/genética , Anciano de 80 o más Años , Arildialquilfosfatasa/genética , Biomarcadores/metabolismo , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/metabolismo , Proteínas del Ojo/genética , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Crecimiento Nervioso/genética , Estrés Oxidativo , ARN/genética , Retina/metabolismo , Enfermedades de la Retina , Serpinas/genética