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Fatigue and musculoskeletal pain are also frequent in patients with psoriasis (PsO) without arthritis (PsA). The current study aimed to assess the impact of an intervention program based on aerobic training to reduce fatigue and musculoskeletal pain in patients with PsO without PsA. A total of 118 male patients with PsO volunteered in the current interventional study and were randomly allocated to the experimental (n = 59) or control group (n = 59). The intervention consisted of a 16-week aerobic training program on a treadmill, three sessions per week, consisting of a warm-up, 35-50 min treadmill exercise (increasing 5 min/4 weeks) at a work intensity of 50-65% of peak heart-rate (increasing 5%/4 weeks), and cooling-down. The functional assessment of chronic illness therapy fatigue scale (FACIT-Fatigue), health assessment questionnaire disability index (HAQ-DI), and visual analog scale (VAS) were compared pre and post intervention. Nutritional intake, maximal aerobic power, lipid profile, serum markers of muscle damage, and body composition were also assessed. When compared to baseline, FACIT-Fatigue, HAQ-DI, and VAS scores were significantly improved without increasing markers of muscle damage. Fat mass percentage, lipid profile, and maximal oxygen consumption were also improved. In conclusion, a 16-week aerobic training program at moderate intensity was safe, well tolerated, and effective in psoriatic patients without PsA. Long-term follow-up studies are required to examine whether these promising results may improve clinical outcomes.

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Recent studies have emphasized that regular exercise should be encouraged as a key part of care and support for people with Down syndrome (DS). However, muscle hypotonia has traditionally been considered a major barrier to resistance training (RT) in people with DS. The main objective of this study was to analyze the impact of circuit RT on markers of muscle damage. The secondary objective was to assess the influence of a RT program on body composition and work task performance. Thirty-six men with DS were recruited and randomly assigned to perform a circuit RT program with six stations 3 days/week for 12 weeks (n = 18) or to a control group (n = 18). Body composition was assessed by bioelectrical impedance analysis. Serum markers of muscle damage (creatine kinase, myoglobin, and lactate dehydrogenase) were determined at baseline and at the end of training weeks 1, 6, and 12. Work task performance was assessed using the weighted pail-carry test. RT did not induce significant changes in markers of muscle damage during the intervention. Furthermore, muscle mass and work task performance were significantly improved in the exercise group. These findings suggest that circuit RT can be used safely to increase muscle mass and work task performance in young adults with DS. Muscle hypotonia should not be considered a major barrier to exercise in people with DS, provided that qualified staff design and supervise all training sessions.

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Introduccion: La hiperplasia adenomatoide de glándulasalival mucosa es una rara entidad clinico patológica descritapor Giansanti et al en 1971. Material y métodos: El caso quenosotros presentamos corresponde a una paciente de 47 añosde edad con cuadros repetitivos de dolor a nivel sublingual.Resultados: Microscópicamente las secciones muestrannumerosos lóbulos de glándula salival con acinos mucosos deapariencia normal en un estroma de tejido conectivo fibroso.Conclusiones: La hiperplasia adenomatoide de glándula salivalmucosa no puede ser diferenciada clínicamente de neoplasiasde glándula salival, siendo necesario que la lesión seaexcindida y sometida a examen microscópico

Background: Adenomatoid hyperplasia of the mucoussalivary glands is an uncommon clinicopathologic entitydescribed by Giansanti et al in 1971. Methods: The reportedcase corresponds to a 47 year-old patient complaining ofsublingual pain repeated crises. Results: Microscopic sectionsshowed numerous salivary gland lobules with normalappearing mucinous acini within a fibrous connective tissuestroma. Conclusions: Adenomatoid hyperplasia of mucoussalivary glands can not be clinically differentiated from salivarygland neoplasms. It is necessary that the lesion be excisedand submitted for microscopic examination

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El carcinoide estrumal es un raro tumor de células germinalesovárico constituido por folículos tiroideos entremezcladoscon un tumor carcinoide. Presentamos el caso deuna mujer de 27 años, asintomática, con hidronefrosis ymasa retrouterina en la ecografía abdominal, que resultócorresponder a un teratoma quístico maduro en el que sedescubrió un carcinoide estrumal. El componente estrumalmostró inmunotinción positiva para tiroglobulina. El tumorcarcinoide de patrón trabecular mostró inmunorreactividadpara cromogranina A y fosfatasa ácida prostática. Revisamoslas características histopatológicas e inmunohistoquímicasde este infrecuente tumor

Background:Strumal carcinoid is a rare ovarian germ celltumor composed of thyroid follicles admixed with carcinoidtumor. Patients and methods: A case of a 27 year-old womanwith hydronephrosis and retrouterine mass revealed by ultrasonographyis reported. An strumal carcinoid was found incidentallywithin a mature cystic teratoma. Results: Immunohistochemicaltechniques revealed the presence of thyroglobulinwithin the strumal tissue. The trabecular carcinoidcomponent was immunoreactive for chromogranin A andprostatic acid phosphatase. Histopathology and immunohistochemicalfeatures of this uncommon tumor are reviewed

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Introducción: El Tumor mülleriano mixto maligno esun tumor de localización ginecológica poco común. Latrompa de Falopio es la localización menos frecuente.Material y Métodos: El caso que nosotros describimoscorresponde a una paciente de 66 años con dolor abdominaly presencia de una masa pélvica en el anejo izquierdo. Serealiza histerectomía y doble anexectomía. Resultados: Laneoplasia distendía y distorsionaba la trompa de Falopioizquierda. Al corte, la trompa estaba ocupada por un tumorblando con áreas hemorrágicas. Microscópicamente eltumor estaba compuesto por elementos malignos epitelialesy estromales con focos diferenciación rabdomiosarcomatosay cartilaginosa. Conclusiones: Cuatro teorías han sidoformuladas para explicar la histogénesis tumoral de los carcinosarcomasde trompa de Falopio. La sobreexpresión dec-erbB-2 en ambos componentes, epitelial y mesenquimal,sugiere un mecanismo carcinogénico común y apoya lahipótesis de histogénesis por conversión implicando unpapel dominante del componente epitelial

Background: Malignant mixed mullerian tumor is anuncommon neoplasm of the female genital tract. The Fallopiantube is most uncommon site. Patients and Methods:The reported case corresponds to a 66 year old woman withabdominal pain. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Results: The neoplasmdistended and distorted the left Fallopian tube. On cut sectionthe tube was filled and expanded by a soft tumor withhemorrhagic areas. Microscopically it was composed ofmalignant epithelial and stromal elements with foci of cartilaginousand rhabdomyosarcomatous differentiation. Conclusions:Four theories have been put forward to explain theorigins of the Fallopian tube carcinosarcomas. C-erbB-2over-expression in both epithelial and mesenchymal componentssuggests a common carcinogenic mechanism for bothcomponents and supports the conversion-histogenesis hypothesisimplicating a dominant role for epithelial component

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Introducción: La coexistencia de un adenocarcinomagástrico y un linfoma gástrico primario fue descrito por primeravez en 1931. Material y Metodos: Presentamos uncaso en una paciente de 40 años con epigastralgia y perdidade peso. La gastroscopia muestra un engrosamiento de plieguesgástricos. Se realiza gastrectomía total. Resultados: Elexamen histológico muestra un adenocarcinoma de patróndifuso con presencia de células en anillo de sello en el senode un infiltrado linfoide denso y difuso con presencia detípicas lesiones linfoepiteliales. Conclusiones: La presentaciónsimultanea de un adenocarcinoma gástrico y un linfomatipo M.A.L.T en un mismo paciente es muy infrecuente,siendo la infección por Helicobacter pylori un factor etiopatogénicoen el desarrollo de ambas neoplasias

Background: A case of simultaneous gastric adenocarcinomaand primary gastric lymphoma was first describedin 1931. Methods: The case we describe corresponds to a40 year-old patient suffering from epigastralgia and loss ofweight. The gastroscopy shows thickened gastric folds. Acomplete gastrectomy is performed. Results: The histologicalexamination shows an adenocarcinoma with a diffusepattern presenting signet ring cells in the core of a dense anddiffuse lymphoid infiltrate, which also presents typicallymphoepithelial lesions. Conclusions: The case of simultaneousgastric adenocarcinoma and mucous associatedlymphoid tissue lymphoma in a patient is very infrequent.The infection by Helicobacter Pylori is an etopathogenicfactor in the development of both neoplasms

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La larga supervivencia de pacientes diagnosticados de neoplasia maligna tras exitosos tratamientos ha incrementado la aparición de segundas neoplasias. Presentamos un caso de una mujer de 74 años con un carcinoma ductal infiltrante de mama. Todos los ganglios linfáticos axilares estaban ampliamente afectados por linfoma no Hodgkin, y 2 ganglios linfáticos mostraron metástasis de carcinoma. El interés de nuestro caso radica en la coexistencia de ambos tumores en los ganglios linfáticos axilares

The long survival of patients diagnosed with malignant neoplasm after successful treatments has increased the incidence of second neoplasms. We report a case of a 74-year-old woman with an invasive ductal breast carcinoma. All axillary lymph nodes were extensively affected by non-Hodgkin’s lymphoma, and two lymph nodes demonstrated metastatic carcinoma. The interest of our case resides in the coexistence of both tumors in the axillary lymph nodes

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La larga supervivencia de pacientes diagnosticados de neoplasia maligna tras exitosos tratamientosha incrementado la aparición de segundas neoplasias. Presentamos un caso de unamujer de 74 años con un carcinoma ductal infiltrante de mama. Todos los ganglios linfáticos axilaresestaban ampliamente afectados por linfoma no Hodgkin, y 2 ganglios linfáticos mostraronmetástasis de carcinoma. El interés de nuestro caso radica en la coexistencia de ambos tumoresen los ganglios linfáticos axilares

The long survival of patients diagnosed with malignant neoplasm after successful treatmentshas increased the incidence of second neoplasms. We report a case of a 74-year-old womanwith an invasive ductal breast carcinoma. All axillary lymph nodes were extensively affected bynon-Hodgkin’s lymphoma, and two lymph nodes demonstrated metastatic carcinoma. The interestof our case resides in the coexistence of both tumors in the axillary lymph nodes

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Introducción: El hemangioendotelioma epitelioide se describió inicialmente en 1982 como un tumor multicéntrico con afectación de pulmón, hígado y de partes blandas. Su histogénesis y su carácter multifocal/metastásico han sido muy debatidos.Material y métodos: Presentamos un caso en una paciente de 62 años con hemoptisis y un patrón radiológico intersticial bilateral. Se realizó lobectomía superior izquierda.Resultados: La pieza de lóbectomía mostraba un aspecto hemorrágico y condensado, hete-rogéneo, sin masas- definidas. Microscópicamente correspondía a un tumor multicéntrico cre-ciendo con un patrón pseudopolipoide, obliterando los espacios aéreos. En otras áreas crecía con -un `patrón angiosarcomatoso. Las células mostraban citoplasmas amplios; sincitiales y núcleos hendidos; inmunohistoqu micamente expresaba factor Vlll y CD31.Conclusiones: Se trata de un tumor vascular de diagnóstico difícil debido a su aspecto epi-telioide y a que muy raramente se presenta con hemoptisis. Es un tumor de malignidad inter-media cuyas características morfológicas no permiten predecir su pronóstico. (AU)

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