RESUMEN
The occurence of members of mos oncogene family in the vertebrates genome has been studied with the help of highly labeled single-stranded DNA probes. These included subgenic v-mos clones as well as the unique sequence--specific recombinants from mos-related human locus gp5 and the K51 locus from rat genome. The probe from gp5 (mos pseudogene) interacts only with DNA of primates and of rodents. On the other hand, mos gene and the gene from K51 locus are present in all vertberates tested. Recent duplication of the main mos gene in Artiodactyla and Perissodactyla orders of mammals was identified. The persistence of K51 and mos genes during evolution indicates their importance. The segregation of three mos-related genes in human-hamster hybrids points to their location on different human chromosomes.
Asunto(s)
Evolución Biológica , Proto-Oncogenes , Animales , Mapeo Cromosómico , Clonación Molecular , Enzimas de Restricción del ADN , Marcadores Genéticos , Humanos , Células Híbridas , Hibridación de Ácido Nucleico , Especificidad de la EspecieRESUMEN
It is suggested that the products of tumour metabolism are able of changing the electrokinetic parameters of lymphoid cells, thus providing the favourable growth conditions for the tumour. The studies have been carried out with ascites strain of the ovary tumour. It is shown that ascite liquid increases the electrophoretic mobility of the lymphoid cells in vivo and of blood lymphocytes of control rats (especially of old animals) in vitro. The changes in electrokinetic parameters of the lymphoid cells may be a cause of insufficient response of the local immune reactions.
Asunto(s)
Neoplasias Ováricas/inmunología , Envejecimiento , Animales , Líquido Ascítico/inmunología , Electroforesis , Femenino , Humanos , Linfocitos/inmunología , Masculino , Trasplante de Neoplasias , RatasRESUMEN
The rate of occurrence of hepatitis A and B virus specific markers in anthropoid apes of the Moscow Zoo (3 chimpanzees, 3 gorillas, 8 orang-outangs) was studied. Long-term persistence of HBs-antigen in orang-outang accompanied by the presence of HBe-antigen and anti-HBs was demonstrated. The presence of anti-HBs in gorillas and orang-outangs was recorded. Antibodies to hepatitis A virus were found in all the animal species examined. Cases of acute virus hepatitis A in orang-outangs are described contracted from the personnel handling the animals and suffering from this type of hepatitis. Morphological features of the course of hepatitis A in the presence of HBs-antigen carrier state are described. The possibility of active immunization of susceptible animals and the personnel of the zoo against viral hepatitides is discussed.
Asunto(s)
Hepatitis A/veterinaria , Hepatitis B/veterinaria , Hominidae , Animales , Animales de Zoológico , Anticuerpos Antivirales/análisis , Biopsia , Gorilla gorilla , Hepatitis A/diagnóstico , Hepatitis A/patología , Hepatitis B/diagnóstico , Hepatitis B/patología , Anticuerpos contra la Hepatitis B/análisis , Antígenos de Superficie de la Hepatitis B/análisis , Antígenos e de la Hepatitis B/análisis , Hepatovirus/inmunología , Hígado/patología , Moscú , Pan troglodytes , Pongo pygmaeusRESUMEN
In cattle, the greatest amount of bile was secreted in the foremilk period. The bile secretion level, liver-intestine transport, and lipid consumption decreased till 90 days of age then got stabilized, whereas the liver-intestine transport of bile acids augmented up to 180 days of age. The lipid concentration in the bile and the latter's lipolytic activity are closely related and both of them increase after transition from monogastric to polygastric type of digestion. The lipids absorption in the intestine and their digestion coefficient in 1 month-old cattle are, respectively: 88.0 and 99.6%; in 3 months: 75.7 and 61.3%; in 6 months: 71.7 and 59.1%; whereas the level of hepato-enteral circulation of lipids is, respectively: 8.2%; 10.5%; 14.5% of their absorbed amount.
Asunto(s)
Bovinos/fisiología , Sistema Digestivo/metabolismo , Metabolismo de los Lípidos , Hígado/metabolismo , Animales , Animales Recién Nacidos , Bilis/metabolismo , Ácidos y Sales Biliares/metabolismo , Transporte Biológico/efectos de los fármacos , Absorción Intestinal/efectos de los fármacos , Lipólisis/efectos de los fármacosRESUMEN
An outbreak of pox disease in Carnivora of the family Felidae occurred in the Moscow Zoo. Two forms of the disease were found: (1) fatal, fulminant pulmonary without skin lesions and (2) dermal with rash. The severity of the dermal form varied from subclinical to lethal. The pulmonary form was characterized by pneumonia and exudative pleuritis, and large concentrations of virus were observed in the lungs and exudate. In addition to Carnivora of the family Felidae, two giant anteaters had a severe form of the disease (dermal with hemorrhages) and died. The agent of the outbreak appeared to be very closely related to cowpox virus; however, pocks developed at a lower temperature than do those that result from infection with cowpox virus. Strains isolated from sick animals were identical to the virus previously isolated from an outbreak of pox among elephants and okapi. The most probable sources of infection were rats that were fed to some of the animals. During the outbreak, a female attendant at the zoo became infected.