RESUMEN

In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.

Asunto(s)

Movimiento Celular/efectos de los fármacos , Diterpenos/química , Diterpenos/farmacología , Neoplasias/tratamiento farmacológico , Proliferación Celular/efectos de los fármacos , Diterpenos/síntesis química , Ensayos de Selección de Medicamentos Antitumorales , Células HT29 , Humanos , Neoplasias/patología , Relación Estructura-Actividad