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El objetivo de este artículo es presentar el caso de una paciente de 10 años y dos meses de edad, con una maloclusión de Clase II,1 tratada con una combinación de aparato de Herbst, aparatología funcional nocturna de estabilización ortopédica sagital diseñada por el autor y aparatología fija multibrackets. Se mostrarán los criterios diagnósticos, el plan de tratamiento, así como los resultados del mismo, analizando cuales han sido las claves en la corrección de la maloclusión. Observaremos también el comportamiento del caso tras casi 5 años después de su finalización (AU)

The aim of this article is to show a case of Class II,1 malocclussion in a 10/2 years old girl, who was treated with a combination of Herbst appliance, an stabilization functional appliance designed by the author and fixed appliances. We will show the diagnosis, treatment objectives and treatment outcomes and we will discuss the results almost 5 years postreatment (AU)

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OBJECTIVE: To calculate the prevalence of white coat hypertension (WCH) in patients recently diagnosed with light hypertension. To compare their demographic features, cardiovascular risk factors, and the level of early organic effect of WCH versus sustained hypertension, and dippers versus non-dippers. DESIGN: Descriptive, crossover study. SETTING: Five urban health centres. PATIENTS: 238 people between 18 and 65 were chosen. After screening, they were diagnosed with light (1993 WHO criteria) or essential hypertension. MEASUREMENTS AND MAIN RESULTS: Patients received: 24-hour out-patient control of blood pressure (BP), analysis, back of eye and electrocardiogram. WCH was defined as mean daily BP < 139/88 mmHg and mean night-time BP < 123/74 mmHg. Non-dippers were those patients whose mean night-time BP went down from the daytime BP by less than 10%. 39.5% had WCH (33.3-45.7). This was associated with women (49.5%), with lower casual systolic and diastolic BP and with isolated systolic hypertension, p < 0.05. Risk of WCH was 2.14 times greater in women (95% CI, 1.24-3.70). There were no significant differences in the cardiovascular risk or morbidity profile between WCH and sustained HT, or between dippers and non-dippers. CONCLUSIONS: WCH is common in patients recently diagnosed with both light and essential hypertension. This makes us think that the use of primary care out-patient monitoring of BP could be efficient in this type of patient. The absence of significant differences between WCH and sustained hypertension, or between dippers and non-dippers, may be due to their hypertension being recent.

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We have performed a phase II study to evaluate the activity and toxicity of ifosfamide and cisplatin as first-line treatment for advanced ovarian cancer. Patients were treated with cisplatin 100 mg/m2 on day 1 and ifosfamide 5 g/m2 in 18-hr continuous infusion on day 1 or 1.5 g/m2 bolus on days 1-5. Between August 1988 and March 1990, 30 women were entered in the trial, 26 of them with measurable disease. The overall clinical response rate was 69% (95% CI: 48-85%), including 34.6% complete responses (95% CI:17-55%). Reassessment laparotomy was performed in 12 cases, and 4 (33%) exhibited a pathologic complete response. For all patients, the median duration of progression-free survival was 14 months, and the median overall survival was 25 months. There were no major differences in the response rate or survival between the two ifosfamide administration modalities. Relevant toxicities were grade IV hematologic toxicity in 11/30 patients and grade IV renal toxicity in 2/30 patients. A patient with grade IV encephalopathy developed a trauma-related cerebral hemorrhage and died 2 months later. The combination of ifosfamide and cisplatin is active in first-line therapy in advanced ovarian cancer, although it does not seem to improve the efficacy or toxicity profile of conventional combinations.

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Six hundred thirty-nine patients with CIN on referral Pap were evaluated cytocolposcopically at the first visit and decided whether to be treated the same day or not. One hundred ninety-two patients (30%) were considered negative. Follow-up evidenced later appearance of CIN in five of them. One hundred fifty-three (24%) were candidates for delayed treatment due to conditions contraindicating same-day treatment. Two hundred ninety-four patients (46%) were randomly allocated in LEEP (149) or excisional laser (145) arms, and treated the same day under local anesthesia. Both arms were comparable. There were three microinvasive carcinomas diagnosed in the surgical specimen. LEEP was faster and produced less bleeding than laser, although required a mean of four slices to remove the lesion. Arterial hypertension after anesthetic infiltration was detected in 26% of cases. Two intraoperative and two delayed bleeders required surgery. The size of lesion and surgical defect were larger than those reported in the literature. Margins were involved in 8 patients (2.7%). Only 4.7% (7/149) of patients randomized to LEEP and 3.4% (5/145) with excisional laser had persistent or recurrent CIN on follow-up. Factors predisposing to failure included depth of surgical defect, grade of lesion, and operator's expertise. With this approach, 69% of patients referred for cytology of CIN were adequately managed in the first visit, which contrasts to classical management that reaches the state of treatment in 30% of patients. LEEP appears to be faster, less costly, and requires less expertise. Its use in conjunction with adequate screening is recommended for developing countries.

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Six hundred thirty-nine patients with CIN on referral Pap were evaluated cytocolposcopically at the first visit and decided whether to be treated the same day or not. One hundred ninety-two patients (30%) were considered negative. Follow-up evidenced later appearance of CIN in five of them. One hundred fifty-three (24%) were candidates for delayed treatment due to conditions contraindicating same-day treatment. Two hundred ninety-four patients (46%) were randomly allocated in LEEP (149) or excisional laser (145) arms, and treated the same day under local anesthesia. Both arms were comparable. There were three microinvasive carcinomas diagnosed in the surgical specimen. LEEP was faster and produced less bleeding than laser, although required a mean of four slices to remove the lesion. Arterial hypertension after anesthetic infiltration was detected in 26% of cases. Two intraoperative and two delayed bleeders required surgery. The size of lesion and surgical defect were larger than those reported in the literature. Margins were involved in 8 patients (2.7%). Only 4.7% (7/149) of patients randomized to LEEP and 3.4% (5/145) with excisional laser had persistent or recurrent CIN on follow-up. Factors predisposing to failure included depth of surgical defect, grade of lesion, and operator's expertise. With this approach, 69% of patients referred for cytology of CIN were adequately managed in the first visit, which contrasts to classical management that reaches the state of treatment in 30% of patients. LEEP appears to be faster, less costly, and requires less expertise. Its use in conjunction with adequate screening is recommended for developing countries.

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