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Dermatosis Facial/etiología , Lupus Eritematoso Sistémico/diagnóstico , Adulto , Humanos , MasculinoRESUMEN
Cat scratch disease (CSD) is usually associated with Bartonella henselae infection in patients with a history of cat exposure, but Bartonella quintana may also be a cause of chronic lympadenopathy in patients with cat or flea contact. The lymph node histopathology of CSD and tuberculosis may be indistinguishable. We report herein the first description of lymph node coinfection with B. quintana and M. tuberculosis in a 32-year HIV-infected woman. Culture of lymph node biopsy material on Columbia agar with sheep blood and on human endothelial cells in shell vial allowed us to isolate not only B. quintana, but also M. tuberculosis hominis.
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Enfermedad por Rasguño de Gato/complicaciones , Infecciones por VIH/complicaciones , Enfermedades Linfáticas/microbiología , Infecciones por Mycobacterium/complicaciones , Adulto , Bartonella quintana/aislamiento & purificación , Enfermedad por Rasguño de Gato/tratamiento farmacológico , Enfermedad por Rasguño de Gato/microbiología , Femenino , Infecciones por VIH/tratamiento farmacológico , Humanos , Enfermedades Linfáticas/complicaciones , Enfermedades Linfáticas/tratamiento farmacológico , Infecciones por Mycobacterium/tratamiento farmacológico , Infecciones por Mycobacterium/microbiología , Mycobacterium tuberculosis/aislamiento & purificaciónRESUMEN
INTRODUCTION: First used as a sedative, thalidomide was taken out the market because of its teratogenicity. Despite other side effects, especially neuropathies, this drug is now again prescribed in various autoimmune and neoplasic diseases. Recently, venous or arterial thrombotic events have been described after the introduction of thalidomide. EXEGESIS: In this report, we describe two new venous thrombosis cases occurring during a treatment with thalidomide. The first case is a 37-year-old man treated for a discoid lupus, who developed three deep-vein thrombosis and a massive pulmonary embolism, with recurrent thrombosis even with an efficient anticoagulation therapy until the final stop of thalidomide. The second one is a 66-year-old woman treated with thalidomide for a multiple myeloma and a melanoma in therapeutic escape, who developed a deep-vein thrombosis two months after the beginning of her treatment. Published reports suggest that most thrombotic events appeared under three months after the introduction of the treatment and that thalidomide could have acted as a precipitating or as a starting factor in a patient population already at risk of thrombosis. Those complications should be particularly severe, but the mechanism underlying thrombosis with thalidomide is unknown. CONCLUSION: A complete coagulation check-up is advised before beginning a treatment with thalidomide.
Asunto(s)
Inmunosupresores/efectos adversos , Talidomida/efectos adversos , Trombosis de la Vena/inducido químicamente , Adulto , Anciano , Femenino , Humanos , Lupus Vulgar/tratamiento farmacológico , Masculino , Melanoma/tratamiento farmacológico , Mieloma Múltiple/tratamiento farmacológico , Neoplasias Cutáneas/tratamiento farmacológicoRESUMEN
Self-propagating high-temperature synthesis provides an attractive practical method for producing advanced materials such as ceramics, composites and intermetallics. This kind of reaction has been investigated in situ using time-resolved X-ray diffraction, with an X-ray synchrotron beam (D43 beamline, LURE, Orsay) coupled to simultaneous IR thermography to study structural transformations and thermal evolution. With short acquisition times (30 ms per pattern) it has been possible to observe several steps before obtaining compounds. Two different compound formations have been described: (i) the different steps of reaction, aluminium melting, subsequent temperature increase and fast reaction between Al and Ni at such temperatures that only Ni and AlNi are solid and all other compositions are liquid and well identified; (ii) the formation of FeAl. Here, a portion of the iron seems to transform into its allotropic phase and this transition stabilizes the reaction temperature at approximately 1173 K. In addition, the aluminium melting during the reaction explains why the nanostructure induced by the mechanical activation is maintained in the end product.