RESUMEN
BACKGROUND: The novel coronavirus disease (COVID-19), declared a global pandemic by the World Health Organization (WHO) on March 11, 2020, and has constituted one of the most serious health challenges of the century, globally. The causative organism was initially named the 2019 novel coronavirus (2019 n CoV) but has subsequently been renamed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The pandemic has so far infected several millions and killed about a million people worldwide. Diabetes mellitus (DM) is one of the leading causes of morbidity worldwide. OBJECTIVES: To examine the critical role diabetes plays in the pathogenesis and prognosis of COVID-19 and to assess the emerging therapies available to fight the pandemic. METHODS: Authors conducted a systematic review of the literature to examine the role of diabetes as comorbidity in the pathogenesis and prognosis of COVID-19 by searching PubMed and Science Direct databases mainly for articles published since the outbreak of the pandemic. RESULTS: Both experimental and observational data from early 2020 suggested that most people with COVID-19 have comorbidities, the most dominant of which are diabetes, cardiovascular disease, and hypertension. Empirical evidence indicates that diabetic patients infected with the COVID-19 disease had the worst outcomes concerning morbidity and mortality. CONCLUSION: A combination of underlying chronic conditions such as hypertension, obesity, and cardiovascular diseases together with altered ACE receptor expression, immune dysregulation via cytokine storm, alveolar and endothelial dysfunction, increased systemic coagulation may put individuals with diabetes at risk for COVID-19 severity. More studies are needed to elucidate how glucose- lowering drugs may modulate the host immune response in diabetic individuals, especially following the administration of potential COVID-19 vaccines.
Asunto(s)
COVID-19 , Diabetes Mellitus , Hipertensión , Vacunas contra la COVID-19 , Diabetes Mellitus/epidemiología , Glucosa , Humanos , Pronóstico , SARS-CoV-2RESUMEN
INTRODUCTION: This study aimed to describe COVID-19 health literacy, coping strategies and perception of COVID-19 containment measures among community members in a Southwestern state in Nigeria. METHODS: A descriptive cross-sectional design was used to enroll 691 respondents from households in Akure, Ondo state using a multi-stage sampling technique. Data were collected using an interviewer-administered questionnaire between 1st and 9th October, 2020. Bivariate Chi-square tests were conducted on respondents' COVID-19 health literacy while multivariate logistic analysis was performed on significant variables. Statistical significance levels were set at p<0.05. RESULTS: Respondents' mean age was 29.93±10.66 years, 352 (50.9%) were males. Also, 292 (49.7%) had high levels of trust in the World Health Organization regarding COVID-19 information, and 31 (33.3%) in the first wealth quintile had good health literacy (χ2=10.459, p=0.033). Respondents below 20 years were twice more likely to have good COVID-19 health literacy (OR=2.304, 95%CI=1.316-4.034, p=0.004). Also, respondents aged 21-29 years were three times more likely to have good COVID-19 health literacy (OR=2.587, 95%CI=1.559-4.293, p≤0.001). CONCLUSIONS: Available media platforms should be actively engaged by the national government to ensure that community members especially the rich are equipped with good health literacy.