RESUMEN
The enzymatic synthetic activity of peripheral blood lymphocytes was changed in the newborns whose mothers suffered from habitual miscarriages and were administered courses of metabolic therapy as part of combined pathogenetic treatment (basis therapy). Metabolic therapy brought about positive shifts which manifested by a reliable activation of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase, this, in its turn, creating favorable conditions for the functioning of the mother-placenta-fetus metabolic system and being conductive to a better adaptation of the newborns in the early neonatal period. Metabolic therapy brought about a twofold reduction of the incidence of fetal hypoxia and hypotrophy.
Asunto(s)
Aborto Habitual/prevención & control , Glicerolfosfato Deshidrogenasa/sangre , Recién Nacido/sangre , Linfocitos/enzimología , Succinato Deshidrogenasa/sangre , Bencenosulfonatos/uso terapéutico , Dipiridamol/uso terapéutico , Congéneres del Estradiol/uso terapéutico , Femenino , Retardo del Crecimiento Fetal/prevención & control , Hipoxia Fetal/prevención & control , Humanos , Hipnóticos y Sedantes/uso terapéutico , Parasimpatolíticos/uso terapéutico , Modalidades de Fisioterapia , Embarazo , Vasodilatadores/uso terapéutico , Niacinato de Xantinol/uso terapéuticoRESUMEN
Study of the cytochemical characteristics of enzymatic activity of peripheral blood cells in the newborns with a history of medium-severe-chronic intrauterine hypoxia revealed shifts in the levels of succinate dehydrogenase and a-glycerophosphate dehydrogenase. These data imply that changed enzymatic activity of dehydrogenases is an unfavorable prognostic sign indicating failure of adaptation and deterioration of reactivity in the early neonatal period.
Asunto(s)
Hipoxia Fetal/metabolismo , Glicerolfosfato Deshidrogenasa/sangre , Recién Nacido/sangre , Linfocitos/enzimología , Succinato Deshidrogenasa/sangre , Enfermedad Crónica , Femenino , Humanos , Oxidación-Reducción , EmbarazoRESUMEN
Leukocytic dehydrogenases (succinate and alpha-glucose phosphate dehydrogenases) and acid and alkaline phosphatase hydrolases activities were cytochemically assayed in 20 healthy women with normal menstrual cycles (controls) and 34 ones with habitual abortions. Ovulation in health was associated with a significant elevation of SDH, alpha-GPDH, and alkaline phosphatase activities. The second peak of enzymic activation, less marked, was recorded on days 20-24 of the cycle. Acid phosphatase activity was reduced by the second phase of the cycle. In women with habitual abortions the activities of redox enzymes (SDH and alpha-GPDH) reduced as against the controls (p less than 0.05, less than 0.01, less than 0.001), and no ovulatory peak of enzymic activation was detectable. The curves of enzymic activities were in good correlation with rectal temperature curves of the examinees. Elevated enzymic activities during ovulation and in the second phase of a normal cycle evidenced a sufficiently high energy supply of these processes. The detected reduction of leukocytic enzymic activities in women with habitual abortions may be used for the early diagnosis of an unfavorable pregnancy course and, possibly, for the prediction of placental insufficiency.
Asunto(s)
Aborto Habitual/enzimología , Leucocitos/enzimología , Aborto Habitual/diagnóstico , Fosfatasa Ácida/sangre , Adolescente , Fosfatasa Alcalina/sangre , Pruebas Enzimáticas Clínicas , Femenino , Glucosafosfato Deshidrogenasa/sangre , Histocitoquímica , Humanos , Embarazo , Pronóstico , Succinato Deshidrogenasa/sangreRESUMEN
Cytologic analysis of lochia in 118 puerperae helped distinguish 5 types of cytograms. A normal postpartum period is characterized by a gradual transition from an inflammatory to regenerative type. Subinvolution of the uterus is associated with a prolonged persistence of the inflammatory regenerative type, this pointing to deceleration of endometrium purification processes. The inflammatory, degenerative-inflammatory, and necrotic cytogram types were characteristic of endometritis of varying severity. The necrotic cytogram type was found the most prognostically unfavorable.
Asunto(s)
Periodo Posparto , Útero/citología , Frotis Vaginal , Endometritis/diagnóstico , Femenino , Humanos , Pronóstico , Trastornos Puerperales/diagnóstico , Factores de Tiempo , Vagina/metabolismoRESUMEN
Myomectomy has been performed during cesarean section in 205 women with a uterine myoma. Guidelines for surgical and anesthesiological management, fluid and transfusion therapy during and after the operation were obtained for this population of women. A stepwise approach was determined to prevent postoperative complications of interventions of a greater scope during cesarean section in women with uterine myoma.
Asunto(s)
Cesárea , Leiomioma/cirugía , Complicaciones Neoplásicas del Embarazo/cirugía , Neoplasias Uterinas/cirugía , Adulto , Terapia Combinada , Proteínas en la Dieta/administración & dosificación , Femenino , Fluidoterapia , Humanos , Nutrición Parenteral , Sustitutos del Plasma/administración & dosificación , Cuidados Posoperatorios/métodos , EmbarazoAsunto(s)
Fenómenos Fisiológicos Sanguíneos , Oxigenoterapia Hiperbárica , Preeclampsia/terapia , Recuento de Eritrocitos/efectos de los fármacos , Índices de Eritrocitos/efectos de los fármacos , Femenino , Hemólisis/efectos de los fármacos , Humanos , Oxigenoterapia Hiperbárica/efectos adversos , Recién Nacido , EmbarazoRESUMEN
The effect of sex hormones administered to pregnant women on the blood system of their progeny was revealed. The changes were noted in different portions of the system: the peripheral blood, bone marrow, spleen, liver. The sex hormones intensified the hemopoiesis in the bone marrow and the spleen of the fetus and inhibited it in the liver. The noted shifts were assessed as the process of acceleration of the functional maturation of the blood system maturation in the fetus.