RESUMEN
The aim of the present study was to assess the potential of biocompatible polymeric nanosheets as topical and transdermal drug-delivery devices. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer order, and their extremely large aspect ratios result in unique properties, including high transparency, flexibility, and adhesiveness. Nanosheet formulations containing betamethasone valerate (BV) as a model drug and consisting of poly (L-lactic acid) or poly (lactic-co-glycolic) acid were fabricated through a spin-coating-assisted layer-by-layer method using a water-soluble sacrificial membrane. The fabricated formulations could incorporate and release higher amounts of BV compared with a commercial ointment, and the amounts could be controlled by the polymers used, the amount of BV added, and the use of controlled-release membranes. The presence of BV had a minimal effect on thickness, transparency, adhesiveness, and moisture permeability of nanosheets, permitting their application to any area of skin for a long period of time. Therefore, this biocompatible polymeric nanosheet formulation represents a novel and promising topical and transdermal drug delivery device, which has potential to deliver drugs regardless of the area of skin.
Asunto(s)
Sistemas de Liberación de Medicamentos , Nanoestructuras/administración & dosificación , Poliésteres/administración & dosificación , Copolímero de Ácido Poliláctico-Ácido Poliglicólico/administración & dosificación , Administración Tópica , Adulto , Animales , Antiinflamatorios/administración & dosificación , Antiinflamatorios/química , Valerato de Betametasona/administración & dosificación , Valerato de Betametasona/química , Liberación de Fármacos , Femenino , Glucocorticoides/administración & dosificación , Glucocorticoides/química , Humanos , Masculino , Nanoestructuras/química , Poliésteres/química , Copolímero de Ácido Poliláctico-Ácido Poliglicólico/química , Ratas sin Pelo , Piel/metabolismo , Porcinos , Adulto JovenRESUMEN
The mol-ecule of the title compound, C(21)H(16)N(2)O, exists in the keto form and the C=O and N-H bonds are mutually cis in the crystal structure, although an enol form would be possible through tautomerism. The dihedral angle between the quinoline and the naphthalene systems is 22.04â (2)°. A bifurcated intramolecular N-Hâ¯(O,N) hydrogen bond is present.