RESUMEN
We report two cases of Paneth cell-like metaplasia of the prostate gland, one in poorly differentiated carcinoma and the second in benign hyperplasia. By light microscopy, the Paneth-like cells were indistinguishable from Paneth cells found in the normal small intestine and ultrastructurally showed electron-dense granules typical of Paneth cells. Immunohistochemical stains were positive for prostate-specific antigen and prostatic acid phosphatase and negative for lysozyme and alpha 1-antitrypsin. The clinical significance of Paneth cell-like metaplasia is unknown and may represent an example of the multipotential metaplastic capability of actively dividing cells.
Asunto(s)
Metaplasia/patología , Próstata/patología , Adenocarcinoma/patología , Anciano , Humanos , Masculino , Persona de Mediana Edad , Hiperplasia Prostática/patología , Neoplasias de la Próstata/patologíaRESUMEN
A tumor initially presenting as a round cell sarcoma in the proximal tibia of a 42-yr-old male disseminated to involve the femur, multiple tarsal bones, and the lungs. In addition to round cell areas resembling lymphoma, other areas of the tumor produced osteoid matrix and still other areas suggested epithelial differentiation. Immunohistochemical staining revealed the presence of epithelial markers in areas of epithelial differentiation, leukocyte markers in areas of lymphomatous differentiation, and neither marker in areas of osteosarcomatous differentiation. The finding of epithelial elements in a primary bone tumor is rare, and this report is one of the first confirming their presence using immunohistochemical markers. The findings are consonant for neither epithelial nor lymphoid neoplasms and in all probability represent multipotential differentiation in a primitive mesenchymal tumor.
Asunto(s)
Neoplasias Óseas/patología , Sarcoma/patología , Adulto , Neoplasias Óseas/diagnóstico por imagen , Neoplasias Óseas/metabolismo , Humanos , Inmunohistoquímica/métodos , Masculino , Radiografía , Sarcoma/diagnóstico por imagen , Sarcoma/metabolismo , Coloración y EtiquetadoRESUMEN
The histogenesis of alveolar soft part sarcoma (ASPS) is a subject of continued debate. Although many recent reports suggest a muscle origin, others advocate a neuroendocrine derivation. A tumor in the chest wall of a 16-year-old woman was diagnosed and treated as ASPS. The light microscopic, electron microscopic, and immunohistochemical findings showed features of both ASPS and paraganglioma. In addition, this lesion was positive for antibody to glucagon, a characteristic of neither ASPS nor paraganglioma, although seen in a few gangliocytic paragangliomas. This case demonstrates the need for continued inquiry into the histogenesis of ASPS.
Asunto(s)
Neoplasias de la Mama/patología , Paraganglioma/diagnóstico , Sarcoma/diagnóstico , Adolescente , Neoplasias de la Mama/ultraestructura , Núcleo Celular/ultraestructura , Citoplasma/ultraestructura , Diagnóstico Diferencial , Femenino , Humanos , Técnicas para InmunoenzimasRESUMEN
We have presented a case of luteoma of pregnancy, an uncommon ovarian lesion that is usually detected incidentally during cesarean section or postpartum tubal ligation. It is felt to be nonneoplastic, is hormonally stimulated, and regresses after childbirth. It is important to distinguish it from neoplastic lesions of the ovary that can occur in the same population, particularly steroid cell tumors, although this can be a difficult differential diagnosis.
Asunto(s)
Neoplasias Ováricas/patología , Complicaciones Neoplásicas del Embarazo/patología , Neoplasia Tecoma/patología , Diagnóstico Diferencial , Femenino , Humanos , EmbarazoRESUMEN
Echinococcosis, although relatively rare in North America, is becoming more prevalent. The rapid diagnosis of hydatid disease, using a noninvasive approach, is highly desirable. This paper describes a rare case of simultaneous pulmonary and renal echinococcosis, without demonstrable liver involvement, diagnosed by cytologic examination of a bronchial aspirate and sputum. This case emphasizes the importance of cytologic evaluation of a variety of body fluids to diagnose multiorgan infection by Echinococcus granulosus.