RESUMEN

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.

Asunto(s)

Genoma Bacteriano , Mycoplasma/genética , Análisis de Secuencia de ADN , Variación Antigénica/genética , Proteínas Bacterianas/genética , Transporte Biológico/genética , Reparación del ADN/genética , Replicación del ADN/genética , ADN Bacteriano/genética , Bases de Datos Factuales , Metabolismo Energético/genética , Genes Bacterianos , Haemophilus influenzae/genética , Datos de Secuencia Molecular , Mycoplasma/inmunología , Mycoplasma/metabolismo , Sistemas de Lectura Abierta , Biosíntesis de Proteínas , Transcripción Genética