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PLoS Negl Trop Dis ; 17(4): e0011248, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-37093863

RESUMEN

Maternal infections during pregnancy can potentially cause birth defects and severe adverse effects in infants. From 2017 to 2018, we investigated the seroprevalence of five antibodies among 436 mother-infant pairs enrolled in a pregnancy cohort study in Coatepeque, Guatemala. Upon enrollment (< 20 weeks gestational age) and shortly after delivery, we measured the prevalence of IgG and IgM antibodies against Toxoplasma gondii (T. gondii), rubella, and cytomegalovirus (CMV) in mothers and newborns and used rapid tests to detect HIV and syphilis (Treponema pallidum) in mothers. The mean cohort age was 24.5 years. Maternal T. gondii IgM and IgG seropositivity was 1.9% and 69.7%, respectively. No women were positive for HIV, syphilis, or rubella IgM. Maternal rubella IgG seropositivity was 80.8% and significantly increased with age. Maternal CMV IgM and IgG seropositivity were 2.3% and 99.5%, respectively. Of the 323 women tested at both timepoints, IgM reactivation occurred in one woman for T. gondii infection and in eight for CMV. No newborn was seropositive for CMV IgM or rubella IgM. One newborn was seropositive for T. gondii IgM. Congenital T. gondii and CMV infections are important public health issues for pregnant women, newborns, and healthcare providers in Coatepeque and Guatemala.


Asunto(s)
Infecciones por Citomegalovirus , Infecciones por VIH , Enfermedades del Recién Nacido , Complicaciones Infecciosas del Embarazo , Rubéola (Sarampión Alemán) , Sífilis , Toxoplasma , Recién Nacido , Embarazo , Femenino , Humanos , Adulto Joven , Adulto , Complicaciones Infecciosas del Embarazo/diagnóstico , Mujeres Embarazadas , Sífilis/epidemiología , Estudios Seroepidemiológicos , Estudios de Cohortes , Incidencia , Guatemala/epidemiología , Inmunoglobulina G , Rubéola (Sarampión Alemán)/epidemiología , Rubéola (Sarampión Alemán)/diagnóstico , Infecciones por Citomegalovirus/epidemiología , Infecciones por Citomegalovirus/diagnóstico , Inmunoglobulina M , Anticuerpos Antivirales , Anticuerpos Antiprotozoarios
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