RESUMEN
OBJECTIVES: To determine the efficacy in the prevention of tumor recurrence, disease free interval and side effects of intravesical epirrubicin post-TUR of superficial bladder tumor. METHODS: From February 1993 to November 1997, 57 patients with stage Ta, T1, grade I, II and III tumor of the bladder were studied. These patients were treated with 50 mg epirrubicin in 50 ml saline solution administered intravesically on 15 occasions for one year after surgery. The mean follow-up was 18 months. The follow-up protocol included clinical, analytical, cytological, US and cystoscopic control evaluations every 3 months for the first year, every 6 months for the second and third year, and yearly thereafter. RESULTS: At a mean follow-up of 30.2 months, 31.5% (18/55) of the patients showed tumor recurrence; the disease free interval was 17 months for the remaining 18 patients and 43 months for the overall group. Cystitis was observed as an adverse effect in 5 of 57 patients (8.8%). CONCLUSIONS: The study shows that prophylactic treatment with intravesical epirrubicin for the prevention of recurrence in superficial bladder tumor has few side effects and its efficacy is similar to that reported in other studies.
Asunto(s)
Antibióticos Antineoplásicos/uso terapéutico , Epirrubicina/uso terapéutico , Recurrencia Local de Neoplasia/prevención & control , Neoplasias de la Vejiga Urinaria/tratamiento farmacológico , Administración Intravesical , Anciano , Anciano de 80 o más Años , Antibióticos Antineoplásicos/administración & dosificación , Epirrubicina/administración & dosificación , Humanos , Persona de Mediana Edad , Neoplasias de la Vejiga Urinaria/patologíaRESUMEN
One gm ceftriaxone was administered i.m. to 266 patients 1 h before urologic surgery. The antimicrobial spectrum and long half life of this beta-lactam make it potentially useful for prophylaxis. Its efficacy was determined by the incidence of infections and antibiotics required postoperatively. Postoperative bacteriuria was determined by two urine cultures: one at discharge from hospital or after catheter removal and another 4 weeks postoperatively. The overall postoperative infection rate was 9.7% and bacteriuria was 11.2%; most of these were asymptomatic. Antibiotics were administered postoperatively in 13.9% of the patients. The foregoing results corroborate the efficacy of this agent given in a single dose for prophylaxis against infection in urologic surgery.
Asunto(s)
Ceftriaxona/uso terapéutico , Complicaciones Posoperatorias/prevención & control , Medicación Preanestésica , Infecciones Urinarias/prevención & control , Enfermedades Urológicas/cirugía , Ceftriaxona/administración & dosificación , Evaluación de Medicamentos , Endoscopía/efectos adversos , Humanos , Infecciones Urinarias/microbiologíaRESUMEN
A case of leiomyoma of the urachus is reported herein. A review of the literature revealed only 6 cases have been reported. Its incidence is suspected to be higher, but this tumor type is only detected when it is large enough or when complications arise such as bleeding, infection, etc. There is no other data of interest except for its rarity.
Asunto(s)
Leiomioma/diagnóstico , Uraco , Adulto , Femenino , HumanosRESUMEN
Fibroepithelial polyps are benign mesodermal tumors that may be localized at any level of the urinary tract. However, the ureter and urethra are uncommon sites and these are rarely found in the bladder. Two cases are described involving the middle ureteral third and the bladder. We discuss the different hypotheses regarding its etiology and describe the clinical features, diagnostic methods and treatment. We underscore its benign natural history, treatment by conservative surgery and non-recurrence.