RESUMEN

AÒ«ai fruit is characterized by the properties of its bioactive compounds; however, this fruit is highly perishable and its compounds are sensitive when exposed to non-optimal environmental factors. Therefore, the objective of this study was to encapsulate the fruit pulp by spray drying to improve the nutritional value and extend the shelf life of the products derived from acai fruit. Maltodextrin was used as a wall material and the process was optimized to obtain the desirable values of the response variables. For this, a central compound design (CCD) was developed to determine the influence of temperature (110-170 °C) and the wall material proportion (5-15 %) on dependent variables: the retention of ascorbic acid, moisture percentage, hygroscopicity, solubility, water activity, and yield. Furthermore, the effects of spray drying on bioactive compounds (AA, TPC, TFC, TA, TCC, GA, CT, and QC) and antioxidant activity (ABTS, DPPH, and ORAC) were evaluated. The maximum design temperature (170 °C) and wall material proportion (15 %) significantly influenced the response variables where encapsulation was applied, with high ascorbic acid retention (96.886 %), low moisture (0.303 %), low hygroscopicity (7.279 g/100 g), low level of water activity (0.255), a water solubility index of 23.206 %, and a high yield of 70.285 %. The bioactive compounds analyzed and the antioxidant capacity presented significant retention values for AA (96.86 %), TPC (65.13 %), TFC (82.09 %), TA (62.46 %), TCC (7.28 %), GA (35.02 %), CT (49.03 %), QC (37.57 %), ABTS (81.24 %), DPPH (75.11 %), and ORAC (15.68 %). Therefore, it is concluded that the powder obtained under these conditions has desirable physical properties, and the drying process preserved a notable retention of bioactive compounds and their antioxidant activities.

RESUMEN

Salmonellae are Gram-negative zoonotic bacteria that are frequently part of the normal reptilian gastrointestinal flora. The main objective of this project was to estimate the prevalence of non-typhoidal Salmonella enterica in the nesting and foraging populations of sea turtles on St. Kitts and in sand from known nesting beaches. Results suggest a higher prevalence of Salmonella in nesting leatherback sea turtles compared with foraging green and hawksbill sea turtles. Salmonella was cultured from 2/9 and identified by molecular diagnostic methods in 3/9 leatherback sea turtle samples. Salmonella DNA was detected in one hawksbill turtle, but viable isolates were not recovered from any hawksbill sea turtles. No Salmonella was detected in green sea turtles. In samples collected from nesting beaches, Salmonella was only recovered from a single dry sand sample. All recovered isolates were positive for the wzx gene, consistent with the O:7 serogroup. Further serotyping characterized serovars Montevideo and Newport present in cloacal and sand samples. Repetitive-element palindromic PCR (rep-PCR) fingerprint analysis and pulsed-field gel electrophoresis of the 2014 isolates from turtles and sand as well as archived Salmonella isolates recovered from leatherback sea turtles in 2012 and 2013, identified two distinct genotypes and four different pulsotypes, respectively. The genotyping and serotyping were directly correlated. To determine the persistence of representative strains of each serotype/genotype in these environments, laboratory-controlled microcosm studies were performed in water and sand (dry and wet) incubated at 25 or 35°C. Isolates persisted for at least 32 days in most microcosms, although there were significant decreases in culturable bacteria in several microcosms, with the greatest reduction in dry sand incubated at 35°C. This information provides a better understanding of the epizootiology of Salmonella in free-ranging marine reptiles and the potential public health risks associated with human interactions with these animals in the Caribbean.

Asunto(s)

Playas , Salmonella enterica/aislamiento & purificación , Agua de Mar/microbiología , Microbiología del Suelo , Tortugas/microbiología , Animales , Cloaca/microbiología , San Kitts y Nevis , Microbiología del Agua

RESUMEN

Professores que desejam utilizar a aprendizagem baseada em equipes (ABE) do inglês team-based learning (TBL) precisam compreender os princípios fundamentais envolvidos na aplicação desta estratégia educacional e a seqüência de eventos necessária para sua implantação efetiva. O objetivo deste artigo é auxiliar o leitor na compreensão do potencial desta estratégia educacional, incluindo sua capacidade de promover a aprendizagem significativa. Existem quatro princípios fundamentais para o uso eficaz do TBL, que serão descritos, assim como o passo-a-passo para quem deseja organizar um curso inteiro ou algumas atividades (aulas), utilizando a aprendizagem baseada em equipes. Ao final, apresentamos os principais atrativos e os desafios para aqueles que desejam incorporar o TBL à sua prática de ensino/aprendizagem.

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Those faculty who want to use Team-based learning in their classes need to understand the basic principles behind this educational strategy and the required steps that should be followed to achieve an effective implementation. The aim of this article is offer a comprehensive view on TBL’s potential as an educational tool, including the expected outcome of students’ meaningful learning and developmental teamwork. The four principles and a step-by-step process to design and deliver a TBL will be described in details, if one wants to use it for a whole discipline or only for isolated insertions within a course. At the end, it will be expected that the reader understand the main strengthens and weaknesses and could able to do an informed decision making about incorporating TBL or not in their teaching practices.

Asunto(s)

Humanos , Aprendizaje , Educación Médica Continua , Educación en Salud/métodos , Estrategias de Salud , Retroalimentación

RESUMEN

Cytochrome P450 (CYP) enzyme inhibitory properties of six chromenylated amide compounds (CAs) from Amyris plumieri are described. Inhibition of CYP microsomes (CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 and CYP2C19) was monitored using a fluorescent assay. Potent inhibition was found against CYP1A1 with IC(50) and K(i) for CA1 (acetamide), being the lowest at 1.547 ± 1.0 µM and 0.37 µM respectively, displaying non-competitive kinetics. The selectivity for CYP1A1 was increased in CA3 (butanamide), which also exhibited cytotoxicity against breast cancer cells, MCF7 with an IC(50) of 47.46 ± 1.62 µM. Structure-activity relationship studies provide insight at a molecular level for CAs with implications in chemoprevention and chemotherapy.

Asunto(s)

Amidas/uso terapéutico , Antineoplásicos Fitogénicos/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Citocromo P-450 CYP1A1/antagonistas & inhibidores , Fitoterapia , Extractos Vegetales/uso terapéutico , Rutaceae/química , Acetamidas/aislamiento & purificación , Acetamidas/farmacología , Acetamidas/uso terapéutico , Amidas/aislamiento & purificación , Amidas/farmacología , Antineoplásicos Fitogénicos/aislamiento & purificación , Antineoplásicos Fitogénicos/farmacología , Benzopiranos/aislamiento & purificación , Benzopiranos/farmacología , Benzopiranos/uso terapéutico , Inhibidores Enzimáticos/aislamiento & purificación , Inhibidores Enzimáticos/farmacología , Inhibidores Enzimáticos/uso terapéutico , Femenino , Humanos , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Relación Estructura-Actividad

Asunto(s)

Investigación Biomédica/ética , Ética Médica , Enfermedades de Transmisión Sexual/transmisión , Experimentación Humana Terapéutica/ética , Poblaciones Vulnerables , Comités de Ética en Investigación , Gobierno Federal , Femenino , Guatemala , Humanos , Masculino , Prisioneros , Trabajo Sexual , Enfermedades de Transmisión Sexual/terapia , Estados Unidos

RESUMEN

Self-medication includes several forms through which the individual him/herself or the ones responsible for him/her decide, without medical evaluation, which drug they will use and in which way for the symptomatic relief and "cure" of a condition. It involves sharing drugs with other members of the family and social group, using leftovers from previous prescriptions or disrespecting the medical prescription either by prolonging or interrupting the dosage and the administration period prescribed. Although few researches have studied aspects of self-medication in children and adolescents, some authors have reported a high prevalence of self-medication in this age group. Similar to adults, the highest consumption of drugs involves the use of analgesics, antipyretics and anti-inflammatory drugs followed by antibiotics. This review describes the global pattern of self-medication in children and adolescents, and discusses public policies aiming to promote health interventions and strategies to prevent self-medication.

Asunto(s)

Política de Salud , Automedicación , Adolescente , Analgésicos/administración & dosificación , Analgésicos/uso terapéutico , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Antiinflamatorios/administración & dosificación , Antiinflamatorios/uso terapéutico , Niño , Humanos , Prevalencia , Medio Social

RESUMEN

Aedes aegypti larvae have developed tolerance to many insecticides used for mosquito control. Moringa oleifera seeds contain a water-soluble lectin (WSMoL) and this paper reports the effect of M. oleifera seed extracts (MoE(1-15)) and WSMoL on development and survival of A. aegypti larvae. WSMoL peptide from in-gel trypsin digestion is also described. MoE(1-15) showed hemagglutinating activity and WSMoL had similarity with flocculating proteins from M. oleifera seeds. MoE(1) and MoE(3) delayed larval development which stopped in the third instar (L3) in MoE(6) and MoE(15). Significant (p<0.0001) larval mortality was only detected in MoE(15). Native WSMoL showed larvicidal activity (LC(50) 0.197 mg mL(-1)) and heated lectin, without hemagglutinating activity, did not kill fourth instar (L4) larvae. Optical microscopy showed that live L4 from MoE(1) presented underlying epithelium, increased gut lumen and hypertrophic segments; dead L4 from WSMoL were absent of underlying epithelium, had increased gut lumen and hypertrophic segments. The presence of hemagglutinating activity in the extracts suggests that soluble lectin promotes the delay of larval development and mortality; furthermore, the absence of larvicidal activity in heat-denatured WSMoL strengthens the involvement of lectin in this activity mechanism.

Asunto(s)

Aedes/efectos de los fármacos , Insecticidas/toxicidad , Lectinas/toxicidad , Moringa oleifera/química , Aedes/crecimiento & desarrollo , Animales , Monitoreo del Ambiente , Larva/efectos de los fármacos , Larva/crecimiento & desarrollo , Control de Mosquitos , Semillas/química , Pruebas de Toxicidad

RESUMEN

Introdução: Uma das funções da terapia renal substitutiva é a remoção da uréia acumulada nos pacientes portadores de insuficiência renal dialítica. Parte desta uréia encontra-se no compartimento muscular, reduzindo a capacidade dialítica de remoção deste soluto. A atividade física pode ser um fator importante que possa contribuir para melhora do fluxo sanguíneo muscular e conseqüente otimização da depuração deste soluto.Este trabalho teve como objetivo analisar, utilizando-se o índice de depuração da uréia por sessão dehemodálise (Kt/V) como parâmetro de eficácia dialítica, os resultados de um programa de exercícios isotônicos pré-dialíticos na qualidade de diálise. Metodologia: Foram analisados dados de quinze pacientes com insuficiência renal crônica (IRC) de ambos os sexos, submetidos à hemodiálise três vezes por semana. Um protocolo de exercícios isotônicos de baixa intensidade precedidos por alongamentos foi aplicado por um mês, imediatamente antes da sessão de hemodiálise. Após a hemodiálise, a concentração plasmática de uréia foi mensurada, o Kt/V determinado e comparado com o do mês anterior obtido com as mesmas condições de hemodiálise quanto à duração, filtro e acesso vascular, sem a aplicação do programa de exercícios. Teste t de Student, com significância de 5%, foi utilizado para análise dos dados. Resultados: Comparando o Kt/V do mês sem exercício (1,4 ± 0,33) com os obtidos após a aplicação do programa de exercícios (1,3 ± 0.3), os valores não foram estatisticamente significativos (p > 0,05). Conclusões: Os resultados sugerem que, na amostra analisada, o programa de exercícios na intensidade, duração e freqüência executados, não resultou na melhora da eficiência dialítica.

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Introduction: One of the functions of the substitutive renal therapy is to remove accumulated urea inindividuals with dialytic renal failure. Part of this urea is found in the muscular compartment reducing the dialytic capacity to remove this solute. Physical activity can be an important contributing factor to improvethe muscle blood flow and consequently the optimization of this solute depuration . The aim of this studywas to analyze the results of a program of a pre-dialytic isotonic exercise, using the standard procedure of measure (Kt/V), as a parameter of the dialysis efficacy. Methodology: Data from fifteen (15) patients from both sexes with chronic renal failure (CRF) who had undergone hemodialysis three times a week were analyzed. A protocol of low intensity isotonic exercises preceded by stretching was applied during a month, immediately before hemodialysis sessions. After hemodialysis, a urea plasmatic concentration was measured; std Kt/Vwas determined and compared with the previous month obtained through the same conditions of hemodialysis according to the length, filter and vascular access, without the exercise program. Student´s t test with 5% of significance was used for data analysis. Results: Comparing the std Kt/V during the month without exercise(1.4 ± 0.33) with the Kt/V obtained after the exercise program (1.3 ± 0.3), the values were not statistically significant (p > 0.05). Conclusions: The results of this analyzed sample have suggested that this program ofexercise carried out in the intensity, length and frequency has not resulted improvement of the dialysis efficacy

Asunto(s)

Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Diálisis Renal/métodos , Fallo Renal Crónico/terapia , Terapia por Ejercicio/métodos

RESUMEN

OBJECTIVE: To investigate the contents of home medicine chests and their relationship with self-medication in children and adolescents in the towns of Limeira and Piracicaba, SP, Brazil. METHODS: This is a descriptive population study based on a home survey of a simple random sample from both towns, comprising 705 households from census sectors selected by means of cluster sampling. INCLUSION CRITERIA: age

Asunto(s)

Almacenaje de Medicamentos/estadística & datos numéricos , Medicamentos bajo Prescripción/administración & dosificación , Automedicación/estadística & datos numéricos , Adolescente , Brasil , Niño , Preescolar , Estudios Transversales , Humanos , Lactante , Recién Nacido , Entrevistas como Asunto , Análisis Multivariante , Factores Socioeconómicos

RESUMEN

OBJETIVO: Analisar as características das farmácias domiciliares e sua relação com a automedicação em crianças e adolescentes dos municípios de Limeira e Piracicaba (SP). MÉTODOS: Estudo descritivo tipo inquérito populacional domiciliar de uma amostra aleatória simples de ambos os municípios, constituída de 705 domicílios de setores censitários selecionados por meio de amostragem por conglomerado. Critérios de inclusão: idade ≤ 18 anos; entrevista obrigatória com um dos responsáveis; inventário da farmácia domiciliar e ter consumido pelo menos um medicamento nos 15 dias prévios à data da entrevista. Segundo o uso de medicamentos, os participantes foram divididos em dois grupos de estudo: automedicação (orientação leiga) e prescrição médica. Foram realizados testes de associação linear, análise descritiva das variáveis e regressão logística múltipla. RESULTADOS: Foram identificados 3.619 medicamentos (média = 5,1/domicílio; 79,6 por cento especialidades farmacêuticas). Os principais cômodos de estoque foram dormitórios (47,5 por cento), cozinha (29,9 por cento) e banheiros (14,6 por cento); 76,5 por cento em caixas de papelão e em locais de fácil alcance a 142 crianças com idade ≤ 6 anos. Considerando somente as especialidades farmacêuticas (n = 2.891), as mais freqüentes foram analgésicos/antipiréticos (26,8 por cento) e antibióticos sistêmicos (15,3 por cento), sendo o estoque desses medicamentos significativamente mais elevado no grupo automedicação (p < 0,01). Guardar medicamentos nos banheiros (razão de chances = 1,59) e grau de instrução dos responsáveis legais ≤ 4 anos do ensino fundamental (razão de chances = 2,40) denotaram maior risco de automedicação. CONCLUSÕES: É comum armazenar medicamentos nos domicílios, sendo importante a efetivação de campanhas visando o uso racional, a diminuição do desperdício e o estoque seguro.

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OBJECTIVE: To investigate the contents of home medicine chests and their relationship with self-medication in children and adolescents in the towns of Limeira and Piracicaba, SP, Brazil. METHODS: This is a descriptive population study based on a home survey of a simple random sample from both towns, comprising 705 households from census sectors selected by means of cluster sampling. Inclusion criteria: age ≤ 18 years; an obligatory interview with at least one guardian; inventory of medicines kept at home; and having taken at least one medication during the 15 days prior to the interview. The participants were split into two groups based on medication: self-medication (lay advice) and medical prescription. Tests of linear association were performed, in addition to a descriptive analysis of the variables and multiple logistic regression. RESULTS: A total of 3,619 medicines were found (mean = 5.1/household; 79.6 percent were pharmaceutical preparations). The rooms most commonly used to store medications were bedrooms (47.5 percent), kitchens (29.9 percent), and bathrooms (14.6 percent); 76.5 percent were in cardboard boxes and within easy reach of 142 children aged ≤ 6 years. Taking the pharmaceutical preparations in isolation (n = 2,891), the most common were analgesics/antipyretics (26.8 percent) and systemic antibiotics (15.3 percent), and the self-medication group had significantly larger stocks of these medications (p < 0.01). Storing medications in the bathroom (odds ratios = 1.59) and legal guardians with ≤ 4 years of primary education (odds ratios = 2.40) indicated greater risk of self-medication. CONCLUSIONS: Keeping medicines at home is a common practice, and it is important to implement campaigns to encourage rational use, reduced waste and safe storage of medicines.

Asunto(s)

Adolescente , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Almacenaje de Medicamentos/estadística & datos numéricos , Medicamentos bajo Prescripción/administración & dosificación , Automedicación/estadística & datos numéricos , Brasil , Estudios Transversales , Entrevistas como Asunto , Análisis Multivariante , Factores Socioeconómicos

RESUMEN

Although leptospirosis is a globally important zoonotic disease that affects humans on all continents, in both urban and rural areas, it often goes undiagnosed because its clinical manifestations are frequently non-specific. Even when leptospirosis is suspected, confirmation is made difficult by problems in isolating the causative organism in culture and by the low sensitivity of the available serological tests. Following torrential rains and flooding in January-February 2005, an outbreak of leptospirosis was suspected in Guyana, South America. Overall, 108 suspected cases presented at a medical post in the East Coast area of Guyana, and some of these cases are described in detail here. A better understanding of the clinical and paraclinical characteristics of leptospirosis should improve the recognition and appropriate treatment of the disease. Health education could reduce exposure, and physicians and primary healthcare workers could be made more aware of the signs and symptoms of leptospirosis.

Asunto(s)

Desastres , Brotes de Enfermedades , Leptospirosis/epidemiología , Mataderos , Adolescente , Adulto , Anciano , Agricultura , Niño , Preescolar , Países en Desarrollo , Diagnóstico Diferencial , Resultado Fatal , Femenino , Guyana/epidemiología , Humanos , Leptospirosis/diagnóstico , Masculino , Persona de Mediana Edad , Embarazo , Factores de Riesgo

RESUMEN

OBJECTIVE: To determine the prevalence of self-medication in children and adolescents in the municipalities of Limeira and Piracicaba, state of São Paulo, and to correlate results with sociodemographic indicators and with the use of health care services (public or private). METHODS: Descriptive population-based study of a simple random sample from the two municipalities, comprised of 772 inhabitants from 85 urban census sectors selected through cluster sampling. INCLUSION CRITERIA: age < or = 18 years; interview with one parent/tutor; consumption of at least one drug in the previous 15 days. Subjects were divided into two study groups according to their pattern of drug use: self-medication (lay advice) and medical prescription. Linear association tests, descriptive analysis of variables and multiple logistic regression tests were carried out to analyze data. RESULTS: The prevalence of self-medication was 56.6%. Mothers (51%) and drugstore employees (20.1%) were most frequently responsible for self-medication. The main groups of self-prescribed drugs were: analgesic/antipyretic and non-hormonal anti-inflammatory drugs (52.9%); drugs acting on the respiratory tract (15.4%) and gastrointestinal drugs (9.6%); and systemic antibiotics (8.6%). The situation that most commonly motivated self-medication were respiratory diseases (17.2%), fever (15%), and headache (14%). Subjects in the age group of 7-18 years (odds ratio = 2.81) and public health care users (odds ratio = 1.52) showed increased risk for self-medication. CONCLUSIONS: The prevalence of self-medication in children and adolescents was high, which reinforces the need for public health interventions aiming at preventing this practice.

Asunto(s)

Padres , Automedicación/estadística & datos numéricos , Adolescente , Brasil/epidemiología , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Análisis Multivariante , Prevalencia , Factores Socioeconómicos

RESUMEN

OBJETIVO: Determinar a prevalência da automedicação em crianças e adolescentes dos municípios de Limeira e Piracicaba (SP), correlacionando-a a indicadores sociodemográficos e utilização de serviços de saúde (pública ou privada). MÉTODOS: Estudo descritivo tipo inquérito populacional domiciliar de uma amostra aleatória simples de ambos os municípios, constituída de 772 moradores procedentes de 85 setores censitários selecionados por meio de amostragem por conglomerado. Critérios de inclusão: idade < 18 anos; entrevista obrigatória com um dos responsáveis legais; ter consumido pelo menos um medicamento nos 15 dias prévios à data da entrevista. Segundo a orientação de uso de medicamentos, os participantes foram divididos em dois grupos de estudo: automedicação (orientação leiga) e prescrição médica. Foram realizados testes de associação linear, análise descritiva das variáveis e regressão logística múltipla. RESULTADOS: A prevalência da automedicação foi de 56,6 por cento. Os principais responsáveis e indutores da automedicação foram as mães (51 por cento) e funcionários de farmácia (20,1 por cento). Os principais grupos de medicamentos administrados na automedicação foram: analgésicos/antipiréticos e antiinflamatórios não-hormonais (52,9 por cento); medicações de ação nos tratos respiratório (15,4 por cento) e gastrointestinal (9,6 por cento); e antibióticos sistêmicos (8,6 por cento). As situações que mais motivaram a automedicação foram afecções respiratórias (17,2 por cento), febre (15 por cento) e cefaléia (14 por cento). Indivíduos na faixa etária de 7-18 anos (razão de chances = 2,81) e usuários de serviços públicos de saúde (razão de chances = 1,52) apresentaram risco aumentado de automedicação. CONCLUSÕES: A prevalência da automedicação em crianças e adolescentes foi alta, reforçando a necessidade de intervenção das autoridades de saúde na prevenção desses agravos.

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OBJECTIVE: To determine the prevalence of self-medication in children and adolescents in the municipalities of Limeira and Piracicaba, state of São Paulo, and to correlate results with sociodemographic indicators and with the use of health care services (public or private). METHODS: Descriptive population-based study of a simple random sample from the two municipalities, comprised of 772 inhabitants from 85 urban census sectors selected through cluster sampling. Inclusion criteria: age < 18 years; interview with one parent/tutor; consumption of at least one drug in the previous 15 days. Subjects were divided into two study groups according to their pattern of drug use: self-medication (lay advice) and medical prescription. Linear association tests, descriptive analysis of variables and multiple logistic regression tests were carried out to analyze data. RESULTS: The prevalence of self-medication was 56.6 percent. Mothers (51 percent) and drugstore employees (20.1 percent) were most frequently responsible for self-medication. The main groups of self-prescribed drugs were: analgesic/antipyretic and non-hormonal anti-inflammatory drugs (52.9 percent); drugs acting on the respiratory tract (15.4 percent) and gastrointestinal drugs (9.6 percent); and systemic antibiotics (8.6 percent). The situation that most commonly motivated self-medication were respiratory diseases (17.2 percent), fever (15 percent), and headache (14 percent). Subjects in the age group of 7-18 years (odds ratio = 2.81) and public health care users (odds ratio = 1.52) showed increased risk for self-medication. CONCLUSIONS: The prevalence of self-medication in children and adolescents was high, which reinforces the need for public health interventions aiming at preventing this practice.

Asunto(s)

Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Padres , Automedicación/estadística & datos numéricos , Brasil/epidemiología , Estudios Transversales , Análisis Multivariante , Prevalencia , Factores Socioeconómicos

Asunto(s)

Endocrinología , Enfermedades del Sistema Endocrino/terapia

RESUMEN

No periodo de janeiro de 1984 a maio de 1994, de 239 criancas com ate 15 anos de idade, picadas por escorpioes pertencentes as especies T. bahiensis (84,9 por cento) e T. serrulatus (15,1 por cento), 17 apresentaram envenenamento grave...

Asunto(s)

Humanos , Recién Nacido , Lactante , Preescolar , Niño , Adolescente , Antivenenos/farmacología , Venenos de Escorpión/antagonistas & inhibidores , Antivenenos/uso terapéutico , Mordeduras y Picaduras/epidemiología , Estudios de Cohortes , Signos y Síntomas , Venenos de Escorpión/clasificación

RESUMEN

La Fibrosis Quística (FQ) es la enfermedad autosómica recesiva más común de los caucasianos potencialmente letal, que afecta a uno de cada 2.500 recién nacidos. A partir de la reciente identificación del gen defectuoso en esta enfermedad se ha conseguido un conjunto de información acerca de la estructura genética, la base mutacional y la función de los productos proteicos. El producto del gen es un canal clorado regulado por el 3,5 monofosfato de adenosina (AMP cíclico), dependiente de la fosforilación por la proteína quinasa (PQ) y que necesita la unión del trifosfato de adenosina (ATP) para la apertura del canal. Se están realizando nuevas investigaciones en cuanto a la terapia con drogas para la FQ y se está evaluando la posibilidad de una exitosa terapia con genes mediante la transferencia del gen normal a células epiteliales de las vías respiratorias (AU)

Asunto(s)

Fibrosis Quística/genética , Biología Molecular , Fibrosis Quística/fisiopatología , Fibrosis Quística/terapia

RESUMEN

La Fibrosis Quística (FQ) es la enfermedad autosómica recesiva más común de los caucasianos potencialmente letal, que afecta a uno de cada 2.500 recién nacidos. A partir de la reciente identificación del gen defectuoso en esta enfermedad se ha conseguido un conjunto de información acerca de la estructura genética, la base mutacional y la función de los productos proteicos. El producto del gen es un canal clorado regulado por el 3',5' monofosfato de adenosina (AMP cíclico), dependiente de la fosforilación por la proteína quinasa (PQ) y que necesita la unión del trifosfato de adenosina (ATP) para la apertura del canal. Se están realizando nuevas investigaciones en cuanto a la terapia con drogas para la FQ y se está evaluando la posibilidad de una exitosa terapia con genes mediante la transferencia del gen normal a células epiteliales de las vías respiratorias

Asunto(s)

Fibrosis Quística/genética , Biología Molecular , Fibrosis Quística/fisiopatología , Fibrosis Quística/terapia

Asunto(s)

Humanos , Masculino , Femenino , Embarazo , Adulto , Adolescente , Anciano , Enfermedades del Sistema Endocrino/diagnóstico , Enfermedades del Sistema Endocrino/etiología , Enfermedades del Sistema Endocrino/tratamiento farmacológico , Hipotálamo/fisiología , Hipófisis/fisiología , Trastornos del Crecimiento , Glándula Tiroides/fisiología , Médula Suprarrenal/fisiología , Médula Suprarrenal/fisiopatología , Gónadas/fisiología , Gónadas/fisiopatología , Diferenciación Sexual , Pubertad , Hormonas Pancreáticas , Hipoglucemia , Lipoproteínas/metabolismo , Obesidad

Asunto(s)

Estadísticas de Salud , Indicadores de Salud , Seguridad Social , Costa Rica

Asunto(s)

Humanos , Masculino , Femenino , Enfermedades del Sistema Endocrino/diagnóstico , Enfermedades del Sistema Endocrino/etiología , Enfermedades del Sistema Endocrino/fisiopatología , Enfermedades del Sistema Endocrino/tratamiento farmacológico