RESUMEN
UNLABELLED: Ovarian carcinoma is a heterogeneus disease. Pathologists classify it in serous, clear cell, endometrioid and mucinos subtypes. Each of these subtypes is associated with different genetic risk factors and molecular events during oncogenesis and it is characterised by distinct mRNA expression profiles. MATERIAL AND METHOD: We have studied 55 pacients with ovarian tumours who underwent surgery in Clinic "Elena Doamna", Iasi between 2005-2008. CA-125 value was determined pre or postoperator. RESULTS: We have investigated the relationship between tumoral type and CA125 value in all studied cases. CONCLUSIONS: By demonstrating the correlations between biomarker expression with stage or prognosis and by demonstrating the variation in expression rates between subtypes we offer persuasive evidence supporting the view that ovarian carcinoma subtypes are different diseases and the value of the biomarker is not always correlated with malignancy.
Asunto(s)
Biomarcadores de Tumor/sangre , Antígeno Ca-125/sangre , Carcinoma/diagnóstico , Neoplasias Ováricas/diagnóstico , Adulto , Carcinoma/inmunología , Carcinoma/patología , Femenino , Humanos , Estadificación de Neoplasias , Neoplasias Ováricas/inmunología , Neoplasias Ováricas/patología , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Sensibilidad y EspecificidadRESUMEN
AIM: The qualitative and quantitative analysis of the histological structure of the Levator Ani (LA) muscle at female patients with pelvi-perineal prolapse (PPP). MATERIAL AND METHODS: After having taken biopsies of LA from 50 patients with PPP, a microscopic qualitative and quantitative study has been performed. This study was done by comparison with a control lot. RESULTS: The connective, muscular and vascular modifications in the structure of the LA are presented, in connection with the hormonal status of patients with PPP and also the influence of these modifications on the anatomic and functional integrity of the pelvic floor. CONCLUSIONS: Applying the hormonal maintenance treatment for menopause patients has become strictly necessary, both in the PPP prophylaxis and after restoring surgeries.
Asunto(s)
Tejido Conectivo/ultraestructura , Menopausia , Diafragma Pélvico/patología , Prolapso Uterino/patología , Adulto , Biopsia , Estudios de Casos y Controles , Terapia de Reemplazo de Estrógeno/métodos , Femenino , Humanos , Persona de Mediana Edad , Perineo/patología , Prolapso Uterino/prevención & controlRESUMEN
The giant bone cell tumour is a benign osteolitical tumour of spongious tissue. The evolving characters claimed the identification of the high-risk tumours for improving the prognostics. There were used samples of primitive tumours from 69 patients, paraffin included and coloured H&E and then examined with interactive digital video software. The quantitative standard measurements of giant cells (aria, perimeter and diameter), stereology (percentual volumes of cells, blood vessels and stroma) and proliferative activity assessment were made on the representative sections. The dimensions of the giant cells are higher in the Grade I and are lower in Grade II and III, with a dimensional variability. Bone giant cell tumours with mitotic rate less 1/mm2 were exclusively nonaggressive. Quantitative studies reveal the morphopathological changing specific for the grading and evolving forms of giant bone cell tumours. The stereology and mitotic activity index are essential predictive indicators and may be used in early detection of agressiveness and malignancy.