RESUMEN
BACKGROUND: Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells. It presents clinically as a solitary asymptomatic nodule and its pathogenesis has been the subject of much debate in the literature. OBJECTIVES: We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature. METHODS: In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases). RESULTS: In total, 58.82 % were men and 41.18 % were women, and the mean age was 31.74 years. The most common site was the oral cavity (61.76 %). The most frequently suspected clinical diagnosis was fibroma (17.65 %). The lesion was poorly defined and diffuse in 85.29 %. Pseudoepitheliomatous hyperplasia was present in 58.82 %. Nuclear atypia was found in 29.41 % and mitoses in 20.59 %. One case was considered malignant (2.94 %) and 2 atypical (5.88 %). Pustulo-ovoid bodies were present in 47.06 % of the cases and S-100 staining was positive in all cases analyzed. CONCLUSIONS: Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.
Asunto(s)
Tumor de Células Granulares/epidemiología , Neoplasias de la Boca/epidemiología , Adolescente , Adulto , Biomarcadores de Tumor , Niño , Preescolar , Gránulos Citoplasmáticos/ultraestructura , Diagnóstico Diferencial , Femenino , Fibroma/diagnóstico , Tumor de Células Granulares/química , Tumor de Células Granulares/diagnóstico , Tumor de Células Granulares/patología , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/química , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/patología , Estudios Retrospectivos , Neoplasias Cutáneas/química , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/epidemiología , Neoplasias Cutáneas/patología , Coloración y Etiquetado , Adulto JovenRESUMEN
Phacomatosis pigmentokeratotica is a rare syndrome defined by the association of an organoid nevus occasionally with sebaceous differentiation, a speckled lentiginous nevus, and other extracutaneous anomalies. The disorder is a consequence of the so-called twin spot genetic mechanism. We describe the first occurrence involving malignant degeneration of both nevus components, giving rise to three basal cell carcinomas over the sebaceous nevus and a malignant melanoma of the superficial spreading type over the speckled lentiginous nevus. This observation, in concert with the other instances reported in the literature, points to the need for adequate patient follow-up to ensure early detection and treatment of any possible associated malignant degeneration.
Asunto(s)
Carcinoma Basocelular/fisiopatología , Síndromes Neurocutáneos/fisiopatología , Nevo Pigmentado/fisiopatología , Neoplasias Cutáneas/fisiopatología , Adulto , Carcinoma Basocelular/complicaciones , Transformación Celular Neoplásica , Progresión de la Enfermedad , Estudios de Seguimiento , Humanos , Masculino , Melanoma/complicaciones , Melanoma/fisiopatología , Síndromes Neurocutáneos/complicaciones , Nevo Pigmentado/complicaciones , Neoplasias Cutáneas/complicacionesRESUMEN
Lymphangioma circumscriptum is an uncommon hamartomatous malformation that is not only localized to an area of skin, but also spreads to subcutaneous tissue and muscle (Whimster's hypothesis). We describe a 7-year-old boy with a bluish plaque on the left side of the back and abdomen with clusters of translucent vesicles (frog spawn). Magnetic resonance imaging showed the lymphangioma had spread to muscles and even fat adjacent to the left kidney. We decided against radical surgery as it would have been too aggressive, and limited excision can produce new surface lymphangiomas.
Asunto(s)
Linfangioma/patología , Neoplasias Cutáneas/patología , Abdomen , Dorso , Niño , Humanos , Linfangioma/cirugía , Imagen por Resonancia Magnética , Masculino , Neoplasias de los Músculos/diagnóstico por imagen , Neoplasias de los Músculos/secundario , Neoplasias de los Músculos/cirugía , Radiografía , Neoplasias Cutáneas/cirugía , Resultado del TratamientoRESUMEN
Kaposi's varicelliform eruption (KVE) is an infection produced by the cutaneous dissemination of herpes virus type 1 or 2. Usually this disease has been described in atopic patients. In this report we present an HIV-positive woman with a Kaposi's varicelliform eruption that started after skin resurfacing with a laser. This is the first report, to the best of our knowledge, of Kaposi's varicelliform eruption after laser resurfacing. The immunodepressed status of the patient may have played a role in her infection.
Asunto(s)
Dermatosis Facial/etiología , Seropositividad para VIH , Erupción Variceliforme de Kaposi/etiología , Terapia por Láser/efectos adversos , Ritidoplastia/efectos adversos , Enfermedades Cutáneas Virales/etiología , Adulto , Femenino , HumanosRESUMEN
No disponible
Asunto(s)
Masculino , Persona de Mediana Edad , Humanos , Gangrena de Fournier/diagnóstico , Genitales Masculinos/microbiología , Gangrena de Fournier/terapia , Antibacterianos/uso terapéuticoRESUMEN
Ossifying fibromyxoid tumors (OFT) of soft parts are very rare neoplasms recently described by Enzinger et al. (1). They usually present as well-circumscribed, slow-growing, asymptomatic subcutaneous masses. A characteristic finding is a fibrous capsule and an incomplete peripheral shell of mature bone. Although most cases behave as benign tumors, a high rate of local recurrences have been described. We describe a 43-year-old male with a perianal subcutaneous tumor of 10 years evolution. The histopathology was compatible with OFT. Due to the subcutaneous location of OFT, both the dermatologist and dermatopathologist need to know about this rare tumor.
Asunto(s)
Fibroma/patología , Osificación Heterotópica/patología , Neoplasias Cutáneas/patología , Neoplasias de los Tejidos Blandos/patología , Adulto , Humanos , MasculinoRESUMEN
We present a case of subungueal keratoacanthoma. The tumor recurred three months after extirpation and didn't resolve spontaneously. The patient need a new surgery a year later. We revised the literature and comment the clinical and histological features that define this distinct entity and differentiate it from common keratoacanthoma and subungueal squamous cell carcinoma.
Asunto(s)
Queratoacantoma/patología , Enfermedades de la Uña/patología , Adulto , Humanos , MasculinoRESUMEN
Kaposi's sarcoma is frequently associated to other primary neoplasias, especially those arising from mononuclear-phagocytic system. A case of Kaposi's sarcoma associated to Hodgkin's disease is presented.