RESUMEN
Objectives: The aim of the present study was to evaluate bone repair in defects induced in the cranium of Wistarrats using β-tricalcium phosphate. Study Design: In this research, we used 30 rats, randomly distributed in threegroups of 10 animals (G1, G2 and G3), corresponding respectively to time of histological evaluation (7, 15 and30 days). This was a paired study, a defect being induced in the parietal bone on either side of the median sagittalsuture of the animals, being the left-hand side the experimental subgroup (filled by biomaterial) and the rightcontrol. The histological evaluation was performed by means of light microscopy. The collected data were submittedto the Fisher Exact test for comparison between the groups and to the McNemar test for comparison betweenthe subgroups (P > 5%). Results: The results showed no statistically significant differences between the groupsand bone regeneration was similar at the different times of evaluation. Conclusions: Therefore, we concluded thatβ-tricalcium phosphate has not contributed significantly to repair process of defects induced in the cranium ofWistar rats (AU)
Asunto(s)
Humanos , Fosfatos de Calcio/uso terapéutico , Sustitutos de Huesos/uso terapéutico , Enfermedades Óseas/terapia , Modelos Animales de Enfermedad , Huesos/lesionesRESUMEN
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Progressive systemic sclerosis is a chronic sclerotic disease which causes diffuse, increased deposition of extracellular matrix in connective tissue with vascular abnormalities, resulting in tissue hypoxia. Aesthetic and facial dysfunction are followed by important oral and facial manifestation of disturbances such as xerostomia, the lack of saliva in the mouth, and its associated complications. Most clinical manifestations begin with tongue rigidity. The facial skin changes and bone resorption of mandible angle are often reported. Other systemic changes include the involvementof internal organs which leads to serious complications as well as disorders in the cardiac muscle and Raynaud´sphenomenon. The objective of the this paper is to report two cases of systemic sclerosis in patients with oral andfacial manifestations of the disease. A brief review of the literature, focusing on deontological alterations is also presented (AU)