RESUMEN

Objective: Hyaluronic acid (HA) has become a commonly used ingredient in topical moisturizing products; however, limitations of delivery of HA to only the surface of skin have hindered leveraging the full capacity of HA for skin rejuvenation. Here, we aimed to evaluate the clinical benefits of a multi-weight HA plus antioxidant complex-based lotion with SPF 30 compared to a single-weight HA plus ceramide-based lotion with SPF 30. Methods: A double-blind comparative study was conducted on 70 female subjects, aged 25 to 65 years with mild-to-moderate facial dryness and visible fine lines and wrinkles, divided evenly into two groups (n=35 per group). Clinical grading of the face, including dryness, roughness, and fine lines, was assessed after once-daily application for up to eight weeks. Results: Daily use of the multi-weight HA plus antioxidant lotion demonstrated significant improvements in all clinical grading assessments (dryness, roughness, and fine lines) as early as Week 2 compared to baseline. Statistically significant improvements in visible dryness, roughness, and fine lines were greater for the multi-weight HA plus antioxidant lotion compared to the single-weight HA plus ceramide-based lotion. Limitations: The overall small sample size. Conclusion: This study showed the enhanced improvement in dryness, roughness, and fine lines following daily utilization of a novel multi-weight HA plus antioxidant complex-based lotion compared to a single-weight HA plus ceramide-based lotion. These improvements may be attributed to the ability of multi-weight HAs to moisturize the skin surface and penetrate the upper surface layers of the skin, combined with the added benefits of key antioxidants.