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Currently, there is growing interest in the potential use of lactoferrin (LTF), a member of the transferrin family, for the improvement of tissue healing. In this sense, a literature search was conducted to integrate data published on the effect of LTF on jawbone repair. PubMed/MEDLINE, Scopus, Embase, Web of Science, LILACS, and Cochrane databases were retrieved according to the PRISMA 2020 statement. Articles in English, Spanish, and Portuguese were recovered, with no year restriction. In vitro, in vivo, and clinical studies were selected. A total of 742 articles were retrieved, 11 of which met the inclusion criteria (5 in vitro and 5 in vivo studies, and one clinical trial). The included data demonstrated wide variations in study design and LTF therapy protocols. Cell proliferation and viability were the primary outcomes evaluated in the in vitro studies, all of which reported a potential effect of LTF on the repair process. Of three in vivo studies, one reported a reduction in the overall healing rate, whereas the other two showed that LTF inhibited bone resorption and increased bone formation. The clinical trial's findings showed that LTF is a potential promoter of wound repair in patients with medication-related osteonecrosis of the jaws. Overall, data from the studies support a potential effect of LTF therapy on the process of jawbone repair.

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Objective: the present equivalence two-arm parallel randomized controlled trial aimed to compare survival and marginal bone loss (MBL) of short implants (≤6 mm) and standard implants (≥8.5 mm) associated with sinus floor elevation (SFE). Methods: adult patients with partial edentulism with occlusal stability in the sinus area and intermediate bone height were selected in this double-blind trial (patient and outcome assessment). Patients were randomly allocated into two groups: standard length implants with SFE (control) or short implants (test). Clinical and radiographic assessments were made at the time of implant placement, 6 months, and annually thereafter up to 2 years after loading. The inter-examiner agreement was analyzed using intraclass correlation coefficient (ICC). One-way ANOVA, Kaplan-Meier, and Log-rank tests were used to compare implant survival (primary outcome) and MBL (secondary outcome) (P<0.05). Results: eight short implants and six standard implants were placed (mean age of patients was 47 ±12.5 years). The implant survival rates were 87.5% for short (one 5 mm implant failed at 7 months) and 100% for standard implants with no statistically significant difference between groups (P=0.4). The mean MBL after 1 year was 0.30 ±0.62 mm for short and 0.21 ±0.36 mm for standard implants (P=0.123). The inter-examiner agreement was set in 0.831. Conclusion: survival of short implants and standard implants associated with SFE was similar after two years of clinical service. Trial registration: Registered on 27-03-2018 at ClinicalTrials.gov (NCT03479333). Funding: This study was partially funded by Capes Finance Code 001 and #88881.187933/2018-01. TPC is partially funded by National Council for Scientific and Technological Development (CNPq - Brazil). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.(AU)

Objetivo: o presente ensaio clínico randomizado de dois braços de equivalência comparou a taxa de sobrevivência e a perda óssea marginal de implantes curtos (≤ 6 mm) e implantes convencionais (≥ 8.5 mm) associados à elevação do seio maxilar. Métodos: edêntulos parciais adultos, com estabilidade oclusal e altura óssea intermediária na região do seio maxilar, foram selecionados neste estudo duplo-cego e alocados randomicamente em dois grupos: implante de comprimento convencional associado à elevação do seio maxilar (controle) ou implante curto (teste). Avaliações clínicas e radiográficas foram realizadas logo após a instalação do implante, seis meses e anualmente por até dois anos. A concordância interexaminador foi avaliada através do coeficiente de correlação intraclasse. Os testes ANOVA de uma via, Kaplan-Meier e Log-rank foram utilizados para comparar a sobrevivência do implante e a perda óssea marginal (P<0.05). Resultados: oito implantes curtos e seis implantes de comprimento convencional foram instalados em onze pacientes (média de idade dos pacientes: 47 ± 12.5 anos). As taxas de sobrevivência dos implantes foram de 87,5% para implantes curtos (um implante de 5 mm falhou aos sete meses), e 100% para implantes convencionais, sem diferença estatisticamente significativa entre os grupos (P=0.4). A perda óssea marginal média após um ano foi de 0.30 ±0.62 mm para implantes curtos e 0.21 ±0.36 mm para implantes convencionais (P=0.123). A concordância interexaminador foi de 0.831. Conclusão: a taxa de sobrevivência de implantes curtos e convencionais associados ao seio maxilar foi semelhante após dois anos de acompanhamento. Registro do estudo: Registrado em 27-03-2018 no ClinicalTrials.gov (NCT03479333).(AU)

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Objective: This is a preliminary descriptive study to evaluate the dimensional accuracy of two biomodels after autoclaving. Materials and methods: Data were obtained using computed tomography (CT) scans of a dry skull, and were used as the basis for the construction of two prototypes using two rapid prototyping techniques: three-dimensional printing (3DP™) with plaster powder; and selective laser sintering (SLS) with polyamide powder. Using 19 cranial landmarks, 10 linear measurements of each prototype were repeated twenty times each using a digital caliper. After that, the SLS and 3DP™ biomodels were autoclaved under the same conditions and technical parameters. Each linear measurement was repeated 20 times after autoclaving, but only for the SLS model because the 3DP™ model deformed during autoclaving. Results and conclusion: The biomodel manufactured with polyamide powder using the SLS technique (SLS model) did not undergo any significant dimensional changes during autoclaving, which suggests that this technique may have potential clinical and surgical applicability.

Objetivo: Este é um estudo preliminar descritivo para avaliar a precisão dimensional de dois biomodelos após aautoclavagem. Materiais e métodos: Os dados foram obtidos por meio de tomografia computadorizada (TC) deum crânio seco, sendo usados como base para a construção de dois protótipos, utilizando duas técnicas de prototipagemrápida: impressão tridimensional (3DP®) com pó de gesso e sinterização seletiva a laser (SLS) de pó depoliamida. Utilizando 19 caracteres cranianos, dez medidas lineares de cada protótipo foram repetidas 20 vezescada uma, utilizando-se um paquímetro digital. Depois disso, os biomodelos de SLS e 3DP® foram autoclavadossob as mesmas condições e parâmetros técnicos. Cada medição linear foi repetida 20 vezes após a autoclavagem,mas apenas para o modelo SLS, pois o modelo 3DP® foi deformado durante a autoclavagem. Resultados e conclusão:Os biomodelos fabricados com pó de poliamida utilizando a técnica SLS (modelo SLS) não sofreram alteraçãodimensional significativa durante a autoclavagem, o que sugere que essa técnica pode ter aplicabilidadeclínica e cirúrgica em potencial.

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