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Eur Rev Med Pharmacol Sci ; 24(22): 11914-11918, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-33275263

RESUMEN

OBJECTIVE: Herein we report clinical and virological data in a patient with COVID-19 infection and a prior history of kidney transplantation who had a good clinical recovery despite systemic infection. PATIENTS AND METHODS: Reverse transcriptase quantitative PCR analysis for the RdRp, N and E target genes detected viral RNA in different types of biological specimens. Whole viral genome sequences were obtained and analyzed from respiratory tract, feces and blood. RESULTS: Viral sequences showed high (~99.9%) homology with the Wuhan seafood market pneumonia virus. Phylogenetic analysis assigned of the SARS-CoV-2 strains to clade G. A rare variant in the orf1ab gene was present in both sequences, while a missense variant was detected only in viral RNA from stool. CONCLUSIONS: The evolution of the COVID-19 systemic infection in the patient presented here was favorable to the hypothesis that immunosuppressive therapy in organ transplant recipients might be involved in viral dissemination. A missense mutation was present in only one specimen from the same patient implying the occurrence of a mutational event in viral RNA, which is suggestive for the presence of an active virus, even though viral isolation is necessary to demonstrate infectivity.


Asunto(s)
COVID-19/virología , Heces/virología , Trasplante de Riñón , Nasofaringe/virología , ARN Viral/genética , Proteínas Virales/genética , Heces/química , Femenino , Rechazo de Injerto/prevención & control , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Inmunosupresores/uso terapéutico , Persona de Mediana Edad , Mutación Missense/genética , Nasofaringe/química , Filogenia , Poliproteínas/genética , ARN Viral/sangre , SARS-CoV-2/genética , Análisis de Secuencia de ARN
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