RESUMEN

BACKGROUND: Ocular symptoms occur in approximately 10% of patients with psoriasis vulgaris. PATIENT: We report the clinical course of a 35-year-old male patient with obstructive meibomian gland dysfunction, keratoconjunctivitis and reduced reflex secretion of both eyes. Psoriasis vulgaris and hypothalamic hypogonadism were also present. Genetic testing (cytogenetic and DNA analysis) was performed because of additional facial dysmorphia, brachydactylia and obesity. No chromosomal anomaly was found and no genetic syndrome has yet been diagnosed. The therapeutic regimen included preservative-free artificial tears, occlusion of the puncta and a systemic dose of doxycycline. Dermatological symptoms were treated topically and the hypogonadism was treated with intramuscular injections of testosterone. CONCLUSION: Lacrimal and meibomian glands are influenced by androgens. Therefore hormonal dysfunction can also have contributed to the blepharokeratoconjunctivitis in this patient.

Asunto(s)

Blefaritis/diagnóstico , Hipogonadismo/diagnóstico , Queratoconjuntivitis Seca/diagnóstico , Psoriasis/diagnóstico , Anomalías Múltiples/diagnóstico , Anomalías Múltiples/genética , Adulto , Blefaritis/genética , Enfermedad Crónica , Oftalmopatías/diagnóstico , Oftalmopatías/genética , Humanos , Hipogonadismo/genética , Cariotipificación , Queratoconjuntivitis Seca/genética , Masculino , Glándulas Tarsales , Psoriasis/genética , Recurrencia

Asunto(s)

Lesiones Oculares/epidemiología , Hospitales Universitarios/estadística & datos numéricos , Oftalmología/estadística & datos numéricos , Distribución por Edad , Austria/epidemiología , Áreas de Influencia de Salud , Niño , Preescolar , Lesiones Oculares/etiología , Lesiones Oculares Penetrantes/epidemiología , Femenino , Humanos , Lactante , Masculino , Distribución por Sexo , Índices de Gravedad del Trauma

Asunto(s)

Lesiones Oculares/epidemiología , Distribución por Edad , Austria/epidemiología , Niño , Femenino , Hospitalización/tendencias , Humanos , Masculino , Índice de Severidad de la Enfermedad , Distribución por Sexo