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The rise in obesity and related chronic noncommunicable diseases (NCDs) during recent decades in Brazil has been associated with increases in the financial burden and risk of impoverishment due to out-of-pocket (OOP) health expenditure. Thus, this study investigated trends and predictors associated with impoverishment due to health expenditure, in the population of São Paulo city, Brazil, between 2003 and 2015. Household data from the São Paulo Health Survey (n = 5475) were used to estimate impoverishment linked to OOP health expenses, using the three thresholds of International Poverty Lines (IPLs) defined by the World Bank at 1.90, 3.20, and 5.50 dollars per capita per day purchasing power parity (PPP) in 2011. The results indicated a high incidence of impoverishment due to OOP disbursements for health care throughout the period, predominantly concentrated among low-income individuals. Lifestyle choices referring to leisure-time physical activity (OR = 0.766 at $3.20 IPL, and OR = 0.789 at $5.50 IPL) were linked to reduction in the risk for impoverishment due to OOP health expenditures whilst there were increases in the probability of impoverishment due to cardiometabolic risk factors referring to obesity (OR = 1.588 at $3.20 IPL, and OR = 1.633 at $5.50 IPL), and diagnosis of cardiovascular diseases (OR = 2.268 at $1.90 IPL, OR = 1.967 at $3.20 IPL, and OR = 1.936 at $5.50 IPL). Diagnosis of type 2 diabetes mellitus was associated with an increase in the probability of impoverishment at only the $1.90 IPL (OR = 2.506), whilst coefficients for high blood pressure presented lack of significance in the models. Health policies should focus on interventions for prevention of obesity to ensure the financial protection of the population in São Paulo city, Brazil, especially targeting modifiable lifestyle choices like promotion of physical activity and reduction of tobacco use.
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Factores de Riesgo Cardiometabólico , Gastos en Salud , Estilo de Vida , Humanos , Brasil/epidemiología , Gastos en Salud/estadística & datos numéricos , Adulto , Persona de Mediana Edad , Femenino , Masculino , Adulto Joven , Pobreza/estadística & datos numéricos , Adolescente , Anciano , Factores de Riesgo , Obesidad/epidemiología , Obesidad/economíaRESUMEN
BACKGROUND: Cardiovascular diseases (CVDs) comprise major causes of death worldwide, leading to extensive burden on populations and societies. Alterations in normal lipid profiles, i.e., dyslipidemia, comprise important risk factors for CVDs. However, there is lack of comprehensive evidence on the genetic contribution to dyslipidemia in highly admixed populations. The identification of single nucleotide polymorphisms (SNPs) linked to blood lipid traits in the Brazilian population was based on genome-wide associations using data from the São Paulo Health Survey with Focus on Nutrition (ISA-Nutrition). METHODS: A total of 667 unrelated individuals had genetic information on 330,656 SNPs available, and were genotyped with Axiom™ 2.0 Precision Medicine Research Array. Genetic associations were tested at the 10- 5 significance level for the following phenotypes: low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL-c), high-density lipoprotein cholesterol (HDL-c), HDL-c/LDL-c ratio, triglycerides (TGL), total cholesterol, and non-HDL-c. RESULTS: There were 19 significantly different SNPs associated with lipid traits, the majority of which corresponding to intron variants, especially in the genes FAM81A, ZFHX3, PTPRD, and POMC. Three variants (rs1562012, rs16972039, and rs73401081) and two variants (rs8025871 and rs2161683) were associated with two and three phenotypes, respectively. Among the subtypes, non-HDL-c had the highest proportion of associated variants. CONCLUSIONS: The results of the present genome-wide association study offer new insights into the genetic structure underlying lipid traits in underrepresented populations with high ancestry admixture. The associations were robust across multiple lipid phenotypes, and some of the phenotypes were associated with two or three variants. In addition, some variants were present in genes that encode ncRNAs, raising important questions regarding their role in lipid metabolism.
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Estudio de Asociación del Genoma Completo , Polimorfismo de Nucleótido Simple , Humanos , Brasil/epidemiología , Femenino , Masculino , Adulto , Persona de Mediana Edad , Lípidos/sangre , Lípidos/genética , LDL-Colesterol/sangre , LDL-Colesterol/genética , Triglicéridos/sangre , Triglicéridos/genética , HDL-Colesterol/sangre , HDL-Colesterol/genética , Dislipidemias/genética , Dislipidemias/sangre , Enfermedades Cardiovasculares/genética , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/epidemiología , FenotipoRESUMEN
Epidemiological studies frequently classify groups based on phenotypes like self-reported skin color/race, which inaccurately represent genetic ancestry and may lead to misclassification, particularly among individuals of multiracial backgrounds. This study aimed to characterize both global and local genome-wide genetic ancestries and to assess their relationship with self-reported skin color/race in an admixed population of Sao Paulo city. We analyzed 226,346 single-nucleotide polymorphisms from 841 individuals participating in the population-based ISA-Nutrition study. Our findings confirmed the admixed nature of the population, demonstrating substantial European, significant Sub-Saharan African, and minor Native American ancestries, irrespective of skin color. A correlation was observed between global genetic ancestry and self-reported color-race, which was more evident in the extreme proportions of African and European ancestries. Individuals with higher African ancestry tended to identify as Black, those with higher European ancestry tended to identify as White, and individuals with higher Native American ancestry were more likely to self-identify as Mixed, a group with diverse ancestral compositions. However, at the individual level, this correlation was notably weak, and no deviations were observed for specific regions throughout the individual's genome. Our findings emphasize the significance of accurately defining and thoroughly analyzing race and ancestry, especially within admixed populations.
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Polimorfismo de Nucleótido Simple , Autoinforme , Pigmentación de la Piel , Humanos , Brasil , Pigmentación de la Piel/genética , Masculino , Femenino , Adulto , Población Blanca/genética , Población Urbana , Población Negra/genética , Grupos Raciales/genética , Persona de Mediana Edad , Genética de PoblaciónRESUMEN
This study aimed to investigate the association between sociodemographic and behavioral factors and obesity from 2014 to 2021 in adults in São Paulo city, Brazil. A prospective study was carried out with 1,241 adults aged 18 years or above who lived in São Paulo and participated in the São Paulo Health Survey cohort (ISA) - Physical Activity and Environment. The outcome was obesity (yes/no), classified by body mass index and specific cut-off points for each age group. The exposure variables included sex, age, education, skin color, marital status, regional health coordination, physical activity in the four domains, and sedentary behaviors. Multilevel logistic regression models were used for longitudinal analysis. This study found a significant increase (27.7%) in the prevalence of obesity (from 22.6% to 28.9%). People who practiced at least 150 minutes of leisure-time physical activity per week (OR = 0.44; 95%CI: 0.26; 0.76), between 10 and 150 minutes per week of commuting physical activity (OR = 0.49; 95%CI: 0.30; 0.80), and had no partner (OR = 0.47; 95%CI: 0.28; 0.78) were less likely to be obese. People aged from 40 to 59 years (OR = 5.00; 95%CI: 2.02; 12.38) and who were black (OR = 4.70; 95%CI: 1.85; 11.95) were more likely to be obese. This study found an increase in the prevalence of obesity during the studied period, with increased odds for middle-aged and black people and decreased odds for those without a partner and those who practice physical activities in their leisure and as a form of commuting. These results can contribute to support programs and policies to control obesity.
O objetivo foi investigar a associação entre fatores sociodemográficos e comportamentais e a ocorrência da obesidade entre 2014 e 2021 em adultos da cidade de São Paulo, Brasil. Realizou-se estudo prospectivo com 1.241 adultos paulistanos, com 18 anos ou mais, participantes da coorte Inquérito de Saúde de São Paulo (ISA) - Atividade Física e Ambiente. O desfecho foi obesidade (sim/não), classificada por meio do índice de massa corporal e com pontos de corte específicos para cada faixa etária. As variáveis de exposição foram: sexo, idade, escolaridade, cor da pele, estado marital, coordenadoria regional de saúde, atividade física nos quatro domínios e comportamentos sedentários. Foram utilizados modelos de regressão logística multinível para a análise longitudinal. Houve aumento significativo de 27,7% na prevalência de obesidade (de 22,6% para 28,9%). Pessoas que praticavam ao menos 150 minutos semanais de atividade física no lazer (OR = 0,44; IC95%: 0,26; 0,76), entre 10 e 150 minutos semanais de atividade física de deslocamento (OR = 0,49; IC95: 0,30; 0,80) e sem companheiro(a) (OR = 0,47; IC95%: 0,28; 0,78) tiveram menos chances de ter obesidade. Pessoas entre 40 e 59 anos (OR = 5,00; IC95%: 2,02; 12,38) e de cor de pele preta (OR = 4,70; IC95%: 1,85; 11,95) apresentaram maiores chances de ter obesidade. O estudo identificou um aumento na prevalência de obesidade durante o período, com aumento nas chances para pessoas de meia idade e cor da pele preta, e diminuição nas chances para pessoas que vivem sem companheiro(a) e para praticantes de atividades físicas no lazer e como forma de deslocamento. Esses resultados podem contribuir para dar suporte a programas e políticas para o controle da obesidade.
El objetivo fue investigar la asociación entre factores sociodemográficos y conductuales y la presencia de la obesidad entre 2014 y 2021 en adultos de la ciudad de São Paulo, Brasil. Se realizó un estudio prospectivo con 1.241 adultos paulistanos, con 18 años o más, participantes de la cohorte Encuesta de Salud de São Paulo (ISA) - Actividad Física y Ambiente. El resultado fue obesidad (sí/no), clasificada a través del índice de masa corporal y con puntos de corte específicos para cada grupo de edad. Las variables de exposición fueron: sexo, edad, escolaridad, color de la piel, estado civil, coordinación regional de salud, actividad física en los cuatro dominios y comportamientos sedentarios. Para los análisis longitudinales se utilizaron modelos de regresión logística multinivel. Hubo un aumento significativo del 27,7% en la prevalencia de la obesidad (del 22,6% al 28,9%). Las personas que practicaron al menos 150 minutos semanales de actividad física por ocio (OR = 0,44; IC95%: 0,26; 0,76), entre 10 y 150 minutos semanales de actividad física de desplazamiento (OR = 0,49; IC95%: 0,30; 0,80) y sin compañero(a) (OR = 0,47; IC95%: 0,28; 0,78) tuvieron menos probabilidades de tener obesidad. Las personas entre 40 y 59 años (OR = 5,00; IC95%: 2,02; 12,38) y de color de piel negra (OR = 4,70; IC95%: 1,85; 11,95) presentaron mayores probabilidades de tener obesidad. El estudio identificó un aumento en la prevalencia de la obesidad durante ese período, con un aumento en las posibilidades para las personas de mediana edad y color de la piel negra, y una disminución en las posibilidades para las personas que viven sin pareja y para las que realizan actividades físicas por ocio y como forma de desplazamiento. Estos resultados pueden contribuir a apoyar los programas y políticas para el control de la obesidad.
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Ejercicio Físico , Obesidad , Factores Sociodemográficos , Factores Socioeconómicos , Humanos , Obesidad/epidemiología , Masculino , Adulto , Femenino , Brasil/epidemiología , Persona de Mediana Edad , Estudios Longitudinales , Prevalencia , Estudios Prospectivos , Adulto Joven , Índice de Masa Corporal , Adolescente , Factores de Riesgo , Conducta Sedentaria , Anciano , Encuestas Epidemiológicas , Conductas Relacionadas con la SaludRESUMEN
The Mediterranean dietary pattern (MPD) has shown promise in preventing low-grade systemic inflammation (LGSI). This study tested if a high adherence to the MDP by younger and older Brazilian adults is associated with lower LGSI and investigated which Mediterranean food components may contribute to these associations. We performed a secondary study on 2015 ISA-Nutrition (290 younger adults (20-59 years old) and 293 older adults (≥60 years old)), a cross-sectional population-based study in São Paulo, SP, Brazil. The adherence to the MDP was assessed using the Mediterranean Diet Score (MedDietScore), obtained from two non-consecutive 24 h dietary recalls (24HDRs). The LGSI score (from plasma CRP, TNF-α, and adiponectin) identified the inflammatory status. Linear regression models assessed the association between LGSI and the MedDietScore. In older adults only, a high adherence to the MDP signified an 11.5% lower LGSI score. Older adults, classified with high adherence to the MDP, differed by consuming lower meat intake and full-fat dairy. Between older adults, the intake of vegetables and olive oil was inversely associated with the levels of LGSI. Thus, among older adults, the intake of some specific Mediterranean food determined high adherence to the MDP and was associated with decreased LGSI.
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Dieta Mediterránea , Inflamación , Humanos , Dieta Mediterránea/estadística & datos numéricos , Persona de Mediana Edad , Brasil/epidemiología , Adulto , Masculino , Femenino , Estudios Transversales , Adulto Joven , Anciano , Factores de Edad , Cooperación del Paciente/estadística & datos numéricos , Proteína C-Reactiva/análisis , Proteína C-Reactiva/metabolismo , Conducta Alimentaria , Patrones DietéticosRESUMEN
The challenges in the characterization of the nutritional quality of grain foods comprise obstacles to public health actions toward promotion of healthier grain-based foods. The present study investigated how carbohydrate metrics related to glycemic index (GI), glycemic load (GL), and warning labels of grain foods consumed by individuals living in São Paulo, Brazil. Information on intake of grain foods at individual level was obtained using 24 h recalls within a cross-sectional population-based survey conducted in 2015. There were 244 unique grain products reported by individuals in the survey, assessed through four metrics of carbohydrate quality, considering contents per 10 g of total carbohydrate: (1) ≥1 g fiber, (2) ≥1 g fiber and <1 g free sugars, (3) ≥1 g fiber and <2 g free sugars, and (4) ≥1 g fiber, and <2 g free sugars per 1 g of fiber. Outcomes included GI, GL, and inclusion of warning labels proposed by the Brazilian National Health Surveillance Agency (ANVISA), the Chilean Ministry of Health (1st and 3rd stages), and the Pan American Health Organization (PAHO). Metrics identified products with lower mean GI (-12.8 to -9.0 [p-values < 0.001]), and GL (-12.5 to -10.3 [p-values < 0.001]). Warning systems showed a certain degree of discrimination between products according to the metrics (p-value < 0.01 each); however, >50% of products with good nutritional quality according to the carbohydrate metrics still would receive warnings. Findings suggest that carbohydrate metrics identified products with lower GI and GL, and current warning labels may not adequately capture overall nutritional quality of grain foods.
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BACKGROUND & AIMS: Low-grade systemic inflammation (LGSI) is critical to developing many chronic diseases. In turn, it has been shown that the diet can modulate favorably or unfavorably the inflammatory status. Thus, evaluating the diet from appropriate approaches is fundamental; to do so, there are different proposals for dietary indexes. We aimed to: (i) investigate the association between three well-known dietary indexes and LGSI biomarkers; (ii) test these associations individually or in combination with an indicator of ultra-processed foods (UFPs) intake. (iii) as an additional aim, hypothesizing that all the indexes should be capable of identifying the inflammatory potential of diet, we tested the hypothesis that these indexes agree and correlate with each other. METHODS: Cross-sectional population-based data of adults and older persons (n = 583). Dietary data were obtained through two non-consecutive 24-h dietary recalls (24HDR) and calculated for Dietary Inflammatory Index (DII), Mediterranean-Style Dietary Pattern Score (MSDPS); Brazilian Healthy Eating Index - Revised (BHEI-R) and energy ingested from UPFs (UPFs ratio). An LGSI score was created from some plasma inflammatory biomarkers [C-Reactive Protein (CRP), tumor necrosis factor-alpha (TNF-α), and adiponectin]. Logistic and linear regression models tested the associations between dietary indexes and LGSI score. RESULTS: The MSDPS and DII were significantly associated with our inflammatory score, but the BHEI-R did not. Including UPFs in regression models did not increase the strength of these associations. CONCLUSIONS: From the three scores, the dietary inflammatory index and the Mediterranean-style dietary pattern score (MSDPS) were the ones that showed significant association with the inflammatory biomarker. The combination of the indexes with a ratio of UPF intake did not increase the significance of our analyses. The best agreement between the indexes was found between MSDPS and UPFs ratio; the only pair of indexes considered concordant and correlated was the BHEI-R and DII.
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Biomarcadores , Proteína C-Reactiva , Alimentos Procesados , Inflamación , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adiponectina/sangre , Biomarcadores/sangre , Brasil , Proteína C-Reactiva/metabolismo , Estudios Transversales , Dieta , Dieta Saludable , Dieta Mediterránea , Ingestión de Energía , Inflamación/sangre , Factor de Necrosis Tumoral alfa/sangreRESUMEN
BACKGROUND: Women's Dietary Diversity Score (WDDS) is an indicator of dietary diversity, a key component of diet quality in women of reproductive age (WRA). Limited information is available regarding its applicability in other population groups. OBJECTIVE: To examine the ability of the Minimum Dietary Diversity for Women (MDD-W) of 5-food groups cutoff to predict micronutrient adequacy in men and women 15 to 65 years old from 8 Latin American countries. METHODS: We used a 24-hour recall from 9216 participants in the Latin American Study on Nutrition and Health (ELANS) to determine Dietary Diversity Score (DDS) based on the consumption of 10 food groups. The Mean Probability of Adequacy (MPA) was associated with DDS for the overall sample, for men, WRA, and women of nonreproductive age (WNRA). Sensitivity and specificity analyses were performed to determine if the 5-food groups cutoff point for MDD can be used to correctly identify men, WRA, and WNRA with adequate micronutrient adequacy (MPA ≥ 0.70). RESULTS: We found a mean DDS of 4.78 ± 1.33 and an MPA of 0.64 ± 0.16, with 59% of participants showing a diverse diet (DDS ≥ 5). The 5-food groups-cutoff point showed a better balance between sensitivity and specificity predicting an MPA ≥0.70 in men, WRA, and WNRA. MPA was significantly associated with DDS in WRA and for men and WNRA, as well. CONCLUSION: The 5-food group MDD, originally intended to be used in WRA, performed equally well in predicting MPA ≥0.70 in men, WRA, and WNRA, and can be used as a proxy of micronutrient adequacy in Latin American population.
Plain language titleAssessment of the FAO Minimum Dietary Diversity Index to Estimate Micronutrients Intake in Urban Cities of 8 Latin America CountriesPlain language summaryThe Women's Dietary Diversity Score (WDDS) proposed by the Food and Agriculture Organization is an indicator that measures the variety of foods consumed by women of reproductive age (WRA), and it has been reported in several studies that the more diverse the diet, the greater the probability of meeting micronutrients requirements. This indicator has not been validated in other population, but few studies have been conducted in the Latin American region. So, we aimed to investigate whether the Minimum Dietary Diversity for Women (MDD-W) established for WRA could also predict sufficient micronutrient intake in men and women aged 15 to 65 years in the Latin American population. To accomplish this objective, we used data from the Latin American Study of Nutrition and Health (Estudio Latino Americano de Nutrición y SaludELANS) that collected dietary data from 24-h recalls from 9216 participants and analyzed the association between DDS and the Mean Probability of Adequacy (MPA). Additionally, we determined if the MDD cutoff point could correctly identify individuals with appropriate vitamin and mineral intake. We found that the overall mean DDS was 4.78 ± 1.33, the MPA was 0.64 ± 0.16, and approximately 59% of participants had a diverse diet. The MDD of 5-food groups cutoff point was demonstrated to be useful in predicting sufficient micronutrient intake for men, WRA, and women over 50 years. Respondents with a DDS ≥5 had higher micronutrient adequacy. These findings suggest that DDS can serve as a proxy for assessing micronutrient adequacy in urban populations beyond WRA. The effect of promoting diverse diets on micronutrient adequacy as part of intervention programs can be captured by the DDS in urban Latin American populations.
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Dieta , Micronutrientes , Humanos , Femenino , Masculino , Micronutrientes/administración & dosificación , Adulto , América Latina , Persona de Mediana Edad , Adolescente , Adulto Joven , Anciano , Dieta/estadística & datos numéricos , Dieta/métodos , Estado Nutricional , Naciones UnidasRESUMEN
Several dietary quality indexes (DQIs) have been proposed to investigate adherence to a healthy diet. However, only a few studies have been conducted to investigate their association with high blood pressure (BP) in Brazil. In the present work, we examine the association between four established DQIs-2020 Healthy Eating Index (HEI-2020), Dietary Approaches to Stop Hypertension (DASH), Alternative Healthy Eating Index (AHEI), and Brazilian Healthy Eating Index (BHEI)-and high BP in a cross-sectional sample of Brazilian adults from the 2015 Health Survey of São Paulo with Focus on Nutrition. Based on two 24 h recalls adjusted for the within-person variation, higher HEI-2020 and BHEI total scores were inversely related to elevated BP (HEI-2020: OR 0.94, BHEI: OR 0.95). Individuals at the second quartile (OR 0.33) and the fourth quartile of BHEI (OR 0.35), as well as individuals with higher scores on dairy components (HEI-2020: OR 0.80, BHEI: OR 0.83, DASH: OR 0.75), and fruit components (AHEI: OR 0.82, HEI-2020: OR 0.72, BHEI: OR 0.77, DASH: OR 0.79) also presented lower odds for the occurrence of elevated BP. In conclusion, healthier diet quality using the HEI-2020 and BHEI indexes and the fruit and dairy components were identified as protective factors for high BP.
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Dieta , Hipertensión , Adulto , Humanos , Brasil , Estudios Transversales , Encuestas EpidemiológicasRESUMEN
Assessing dietary inadequacies can contribute to understanding the nutritional vulnerabilities of a country. This study aimed to investigate nutrient intakes and micronutrient inadequacies in the Brazilian adult population, with an interest in different age subgroups. We conducted a cross-sectional study with 1812 individuals aged 19 to 65 years from a population-based study with a representative sample of Brazilian adults. Dietary intake was assessed by two 24 h food recalls, and the probabilities of inadequate intake were estimated using the Dietary Reference Intake targets. Adequate macronutrient intake was over 99% for proteins, 84.7% for carbohydrates, and 80.7% for total fats. There was a high probability of inadequacy (above 90%) for vitamins D and E, but vitamin D inadequacy was very similar between the sexes. In contrast, vitamin E was more likely to be inadequately consumed among women. A high probability of inadequacies (above 85%) of calcium and magnesium were found in the population, regardless of age group. Except for iron, the probability of an inadequacy of other minerals increased with age. The results showed a relevant proportion of nutrient inadequacies, with those most at risk being women and older individuals, helping with the better targeting and monitoring of public-health policies that address nutritional problems in the population.
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Dieta , Ingestión de Energía , Adulto , Humanos , Femenino , Masculino , Estudios Transversales , Brasil , Necesidades Nutricionales , Vitaminas , MicronutrientesRESUMEN
ABSTRACT Objective This study aimed to estimate the daily energy intake and overconsumed nutrients for adolescents and young adults concerning public health based on the food source, eating location, and occasion. Methods This study constituted a cross-sectional analysis of the 2015 Health Survey of São Paulo focusing on Nutrition with 707 adolescents (n=554, 12-19 years) and young adults (n=153, 20-30 years). Dietary intake was measured using 24 h recall, and energy, added sugars, sodium, and saturated food sources were calculated. Foods were classified using the "What We Eat in America?" classification system. Eating locations were divided into two categories-at home and away from home-for each main meal (breakfast, lunch, and dinner). Other sociodemographic and weight status variables were included. Descriptive statistics, the Wald test, and proportion rates were applied for analysis. Results Most meals were consumed at home by 80.5% of adolescents and 66.4% of young adults. Young adults consumed more daily calories and saturated fats than adolescents. Both adolescents and young adults consumed equal daily saturated fatty acids, sodium, and added sugars away from home at dinner. Food consumed at home was consumed both at home and away from home, with the main exception of dinner, which consisted of mainly processed foods rich in saturated fatty acids, sodium, and added sugars consumed away from home. Conclusion Adolescents and young adults had meals higher in fat, sugar and sodium away from home than those who ate at home when eaten at dinner. Public health policies and behavioral change strategies should be considered independently of where their meals are consumed but with particular attention to eating occasions.
RESUMO Objetivo Este estudo teve como objetivo estimar a ingestão diária de energia e nutrientes de maior preocupação em saúde pública entre adolescentes e jovens adultos, com base nos alimentos fonte, local e tipo de refeição. Métodos Este estudo é de delineamento transversal que utilizou dados do Inquérito de Saúde do Município de São Paulo 2015 (ISA-Capital) focado na Nutrição. A amostra compreendeu 707 adolescentes (n=554, 12-19 anos) e adultos jovens (n=153, 20-30 anos). O consumo alimentar foi avaliado por meio do Recordatório Alimentar de 24h (R24H) e a calculou-se as fontes de energia, açúcar de adição, sódio, e gordura saturada. Os alimentos foram classificados pelo sistema de classificação "What We Eat in America?" Os locais de alimentação foram divididos em duas categorias - "em casa" e "fora de casa" - para cada refeição principal (café da manhã, almoço e jantar). Outras variáveis sociodemográficas e antropométricas foram incluídas. Estatísticas descritivas, teste de Wald e proporções foram aplicadas para análise. Resultados A maioria das refeições era consumida em casa por 80,5% dos adolescentes e 66,4% dos adultos jovens. Os adultos jovens consumiam mais calorias diárias e gorduras saturadas do que os adolescentes. Tanto adolescentes, quanto adultos jovens, consumiam majoritariamente ácidos graxos saturados, sódio e, açúcares de adição fora de casa, no jantar. Os alimentos consumidos em casa eram consumidos tanto em casa quanto fora de casa, com a principal exceção do jantar, que consistia, principalmente, em alimentos processados ricos em ácidos graxos saturados, sódio e açúcares de adição consumidos fora de casa. Conclusão Adolescentes e adultos jovens apresentaram refeições mais ricas em gordura, açúcares e sódio fora de casa em comparação com aqueles que consomem em casa quando consumidos no jantar. Políticas de saúde pública e estratégias de mudança de comportamento devem ser consideradas independentemente do local onde suas refeições são consumidas, mas com especial atenção ao tipo de refeição.
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BACKGROUND: Latin American countries have shifted from traditional diets rich in micronutrients to a Westernized diet rich in high energy-dense foods and low in micronutrients. OBJECTIVE: This study aimed to determine the prevalence of adequate micronutrient intakes in urban populations of 8 Latin American countries. METHOD: Micronutrient dietary intake data were collected from September 2014 to August 2015 from 9216 men and women aged 15.0 to 65.0 years living in urban populations of 8 Latin American countries. Dietary intake was collected using two 24-hour recalls on nonconsecutive days. Micronutrient adequacy of intake was calculated using the Estimated Average Requirement cut-off method. RESULTS: In general terms, the prevalence of inadequate intake of thiamine, riboflavin, niacin, folate, cobalamin, iron, phosphorus, copper, and selenium ranged from 0.4% to 9.9%. In contrast, the prevalence of inadequacy of pyridoxine, zinc, vitamin C, and vitamin A ranged from 15.7% to 51.5%. The nutrients with a critical prevalence of inadequacy were magnesium (80.5%), calcium (85.7%), and vitamin D (98.2%). The highest prevalence of inadequate intakes was observed in the low educational level, participants with overweight/obesity, in men, and varies according to socioeconomic status. CONCLUSIONS: There is an urgent need to define direct regional actions and strategies in Latin America aimed at improving micronutrient adequacy, either through staple food fortification programs, agronomic biofortification, or food policies that facilitate economic access to micronutrient-rich foods.
Plain language titleDescription of the Vitamin and Mineral Consumption Status in Urban Cities of Latin America: Results of the Latin American Health and Nutrition Study.Plain language summaryVitamins and minerals are essential for maintaining good health. However, traditional Latin American diets are changing to include foods that have a lot of sugar and fat but fewer vitamins and minerals. This study was designed to analyze the consumption of these nutrients in urban cities of 8 Latin American countries. We collected food consumption information from September 2014 to August 2015 from 9216 men and women between 15 and 65 years old using a method called 24-hour recall. To find out if participants were consuming the necessary daily amounts of vitamins and minerals, intakes were compared with the daily recommended amounts suggested by the Institutes of Medicine of the United States. We found that Latin American urban populations consume fewer vitamins and minerals than recommended. In some cases, few people do not consume the required amounts of vitamins and minerals, but in other cases, many do not. For example, few do not consume enough thiamine, riboflavin, niacin, folate, cobalamin, iron, phosphorus, copper, and selenium. However an intermediate number of people do not consume enough pyridoxine and zinc, a high number consume little vitamin C and vitamin A, and many people consume very little magnesium, calcium, and vitamin D. We found that the people who consume fewer vitamins and minerals are mostly males, overweight/obese, have lower education and varies according to their financial resources. A deficient intake of vitamins and minerals showed up in most age groups, from adolescence to adulthood. To improve vitamins and minerals intake, it is important that some foods that are frequently eaten are fortified or that the price of foods that are high in vitamins and minerals is lowered.
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Dieta , Micronutrientes , Población Urbana , Humanos , Masculino , Femenino , Micronutrientes/administración & dosificación , Micronutrientes/análisis , Persona de Mediana Edad , Anciano , América Latina/epidemiología , Población Urbana/estadística & datos numéricos , Adolescente , Adulto , Dieta/estadística & datos numéricos , Dieta/métodos , Adulto Joven , Estado Nutricional , Encuestas NutricionalesRESUMEN
Resumo: O objetivo foi investigar a associação entre fatores sociodemográficos e comportamentais e a ocorrência da obesidade entre 2014 e 2021 em adultos da cidade de São Paulo, Brasil. Realizou-se estudo prospectivo com 1.241 adultos paulistanos, com 18 anos ou mais, participantes da coorte Inquérito de Saúde de São Paulo (ISA) - Atividade Física e Ambiente. O desfecho foi obesidade (sim/não), classificada por meio do índice de massa corporal e com pontos de corte específicos para cada faixa etária. As variáveis de exposição foram: sexo, idade, escolaridade, cor da pele, estado marital, coordenadoria regional de saúde, atividade física nos quatro domínios e comportamentos sedentários. Foram utilizados modelos de regressão logística multinível para a análise longitudinal. Houve aumento significativo de 27,7% na prevalência de obesidade (de 22,6% para 28,9%). Pessoas que praticavam ao menos 150 minutos semanais de atividade física no lazer (OR = 0,44; IC95%: 0,26; 0,76), entre 10 e 150 minutos semanais de atividade física de deslocamento (OR = 0,49; IC95: 0,30; 0,80) e sem companheiro(a) (OR = 0,47; IC95%: 0,28; 0,78) tiveram menos chances de ter obesidade. Pessoas entre 40 e 59 anos (OR = 5,00; IC95%: 2,02; 12,38) e de cor de pele preta (OR = 4,70; IC95%: 1,85; 11,95) apresentaram maiores chances de ter obesidade. O estudo identificou um aumento na prevalência de obesidade durante o período, com aumento nas chances para pessoas de meia idade e cor da pele preta, e diminuição nas chances para pessoas que vivem sem companheiro(a) e para praticantes de atividades físicas no lazer e como forma de deslocamento. Esses resultados podem contribuir para dar suporte a programas e políticas para o controle da obesidade.
Abstract: This study aimed to investigate the association between sociodemographic and behavioral factors and obesity from 2014 to 2021 in adults in São Paulo city, Brazil. A prospective study was carried out with 1,241 adults aged 18 years or above who lived in São Paulo and participated in the São Paulo Health Survey cohort (ISA) - Physical Activity and Environment. The outcome was obesity (yes/no), classified by body mass index and specific cut-off points for each age group. The exposure variables included sex, age, education, skin color, marital status, regional health coordination, physical activity in the four domains, and sedentary behaviors. Multilevel logistic regression models were used for longitudinal analysis. This study found a significant increase (27.7%) in the prevalence of obesity (from 22.6% to 28.9%). People who practiced at least 150 minutes of leisure-time physical activity per week (OR = 0.44; 95%CI: 0.26; 0.76), between 10 and 150 minutes per week of commuting physical activity (OR = 0.49; 95%CI: 0.30; 0.80), and had no partner (OR = 0.47; 95%CI: 0.28; 0.78) were less likely to be obese. People aged from 40 to 59 years (OR = 5.00; 95%CI: 2.02; 12.38) and who were black (OR = 4.70; 95%CI: 1.85; 11.95) were more likely to be obese. This study found an increase in the prevalence of obesity during the studied period, with increased odds for middle-aged and black people and decreased odds for those without a partner and those who practice physical activities in their leisure and as a form of commuting. These results can contribute to support programs and policies to control obesity.
Resumen: El objetivo fue investigar la asociación entre factores sociodemográficos y conductuales y la presencia de la obesidad entre 2014 y 2021 en adultos de la ciudad de São Paulo, Brasil. Se realizó un estudio prospectivo con 1.241 adultos paulistanos, con 18 años o más, participantes de la cohorte Encuesta de Salud de São Paulo (ISA) - Actividad Física y Ambiente. El resultado fue obesidad (sí/no), clasificada a través del índice de masa corporal y con puntos de corte específicos para cada grupo de edad. Las variables de exposición fueron: sexo, edad, escolaridad, color de la piel, estado civil, coordinación regional de salud, actividad física en los cuatro dominios y comportamientos sedentarios. Para los análisis longitudinales se utilizaron modelos de regresión logística multinivel. Hubo un aumento significativo del 27,7% en la prevalencia de la obesidad (del 22,6% al 28,9%). Las personas que practicaron al menos 150 minutos semanales de actividad física por ocio (OR = 0,44; IC95%: 0,26; 0,76), entre 10 y 150 minutos semanales de actividad física de desplazamiento (OR = 0,49; IC95%: 0,30; 0,80) y sin compañero(a) (OR = 0,47; IC95%: 0,28; 0,78) tuvieron menos probabilidades de tener obesidad. Las personas entre 40 y 59 años (OR = 5,00; IC95%: 2,02; 12,38) y de color de piel negra (OR = 4,70; IC95%: 1,85; 11,95) presentaron mayores probabilidades de tener obesidad. El estudio identificó un aumento en la prevalencia de la obesidad durante ese período, con un aumento en las posibilidades para las personas de mediana edad y color de la piel negra, y una disminución en las posibilidades para las personas que viven sin pareja y para las que realizan actividades físicas por ocio y como forma de desplazamiento. Estos resultados pueden contribuir a apoyar los programas y políticas para el control de la obesidad.
RESUMEN
BACKGROUND AND AIMS: Aging is a major factor in development of chronic non-communicable diseases (NCD). Epigenetic causes are risk factors in NCD development since studies indicate that the expression of micro-ribonucleic acids (miRs) is altered under different clinical conditions. This study aimed to analyze the expression profile of circulating miRs and investigate their association with biomarkers of cardiometabolic risk in older adults living in São Paulo municipality, Brazil. METHODS: A cross-sectional study was conducted based on the analysis of data from 200 older adults, with a mean age of 69.1 (0.5) years old participating in the ISA-Nutrition. The expression profiles of 21 plasma miRs related to glycemic and lipid metabolism, adiposity, and inflammation were evaluated in relation to cardiometabolic risk. Individuals were distributed into groups according to diagnosis of metabolic syndrome (MetS). The Stata Somersd module was used to calculate confidence intervals for Kendall's tau-a to estimate the correlations among variables. RESULTS: Differences in the plasma expression were observed in two of the 21 miRs evaluated according to the MetS presence in participants. Individuals with MetS showed higher expression of miR-30a and miR-122 than individuals without MetS. CONCLUSIONS: Considering that miR-30, and miR-122 were altered due to MetS, these miRs may be potential biomarkers for MetS in older adults.
Asunto(s)
Enfermedades Cardiovasculares , Síndrome Metabólico , MicroARNs , Enfermedades no Transmisibles , Humanos , Anciano , Lactante , Estudios Transversales , Brasil/epidemiología , MicroARNs/metabolismo , BiomarcadoresRESUMEN
Inflammaging refers to the low-grade systemic inflammation that occurs with aging present in chronic non-communicable diseases. MicroRNAs (miRNAs) are potential biomarkers for these diseases in older adults. This study aimed to assess the expression of 21 circulating miRNAs and their associations with inflammatory biomarkers in older adults. This cross-sectional study was performed with 200 individuals participating in ISA-Nutrition. The systemic low-grade inflammation score (SIS) was calculated from the plasma concentration of 10 inflammatory biomarkers. Circulating miRNA expression was assessed using the Fluidigm method. Wilcoxon-Mann-Whitney test was employed to determine differences in SIS among groups distributed according to sex and presence of MetS. Spearman's correlation was used to estimate correlations among SIS, leptin levels, miRNA expression, and variables of interest. Analyses were performed using software R version 4.2.3, with a significance level of 0.05. The final sample consisted of 193 individuals with a mean age of 69.1 (SE = 0.5) years, being 64.7% individuals with metabolic syndrome (MetS). Positive correlations were observed between leptin concentration and metabolic risk factors, and leptin concentration was higher in individuals with MetS compared to those without MetS. The expression of 15 circulating miRNAs was negatively correlated with leptin concentration. GLMs showed negative associations between miRNAs (miR-15a, miR-16, miR-223, miR-363, miR-532), leptin, and/or SIS values; and only miR-21 showed positive association with SIS values. The results suggest the presence of peripheral leptin resistance associated with low-grade inflammation and plasma expression of miRNAs in older adults. These findings suggest the potential role of miRNAs as biomarkers for cardiometabolic risk.
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Síndrome Metabólico , MicroARNs , Humanos , Anciano , Leptina , Estudios Transversales , MicroARNs/genética , Síndrome Metabólico/diagnóstico , Biomarcadores , InflamaciónRESUMEN
Different dietary indexes are proposed to investigate adherence to the Mediterranean diet (MD). However, they are based on different methodologies, and limited research has compared them to each other, particularly in non-Mediterranean populations. We aimed to compare five indexes intended to measure adherence to the MD. The sample was composed of adults and older adults (n 1187) from 2015 ISA-Nutrition, a cross-sectional population-based study in São Paulo, SP, Brazil. Dietary data obtained through two 24-h dietary recalls (24HDR) from which the Mediterranean diet scale (MDS), Mediterranean diet Score (MedDietscore), Mediterranean dietary pattern (MDP), Mediterranean Adequacy Index (MAI) and Mediterranean-Style Dietary Pattern Score (MSDPS) were calculated. The correlations and agreements between them were analysed by Spearman's correlation and linearly weighted Cohen's Kappa coefficients, respectively. Confirmatory factor analyses (CFAs) were applied to investigate their convergent validity. The highest correlations were found between MDP and MAI (r = 0â 76; 95% CI 0â 74-0â 79) and between MDP and MDS (r = 0â 72; 95% CI 0â 69-0â 75). The greatest agreements observed were moderate, between MDP v. MAI (κ = 0â 57, P < 0â 001) and MDP v. MDS (κ = 0â 48, P < 0â 001). The goodness-of-fit of CFA for MedDietscore (RMSEA = 0â 033, 90% CI 0â 02-0â 042; SRMR = 0â 042) and MSDPS (RMSEA = 0â 028, 90% CI 0â 019-0â 037; SRMR = 0â 031) had acceptable values for absolute fit indices. Vegetables, olive oil, MUFA:SFA ratio and cereals with legumes were more relevant to characterise the MD (factor loadings ≥0â 50). The MDS, MAI and MDP classified the population similarly, but the MedDietscore showed better performances in evaluating adherence to the MD. These results provided guidance for the most appropriate Mediterranean dietary index to be applied in non-Mediterranean populations.
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Dieta Mediterránea , Brasil , Estudios Transversales , Verduras , Estado NutricionalRESUMEN
BACKGROUND & AIMS: We aimed to estimate the prevalence of the inadequate intake and status of magnesium, zinc, and vitamins A, C, E, and D and identify factors associated with micronutrient deficiency in serum/plasma among residents of São Paulo, Brazil. METHODS: Data from 824 individuals aged ≥14 years were obtained from the 2015 ISA-Nutrition, a population-based, cross-sectional survey. Dietary and supplement intakes were assessed using two 24-h dietary recalls, and the micronutrient inadequacies were estimated using the National Cancer Institute method. Micronutrient status was measured in serum or plasma, and deficiency was established according to the lower limit of the reference values. Receiver operating characteristic curve analysis was used to identify the effect of intake on the micronutrient status in serum/plasma. Logistic regression analysis was applied to assess the association between micronutrient status and individual characteristics. RESULTS: More than 80% of the population had an inadequate dietary intake of magnesium, vitamin E, and vitamin D. Males had a high prevalence of inadequate dietary intake of vitamin A and zinc. A high-to-moderate prevalence of inadequate vitamin C intake was observed. Vitamin D was the only nutrient with a deficient status comparable to its dietary inadequacy. The other nutrients demonstrated a lower deficiency prevalence compared to dietary inadequacy, and vitamin A demonstrated the lowest prevalence of deficiency in plasma. Generally, dietary intake showed a non-notable association with micronutrient deficiency in serum/plasma. Individuals with fasting glucose concentrations ≥100 mg/dL and those using diuretic drugs had a higher risk of serum magnesium deficiency. Those using lipid-lowering drugs and those with high plasma adiponectin concentrations had a higher risk of serum zinc deficiency. Individuals who smoked and those with hypertension showed a higher risk of plasma vitamin C deficiency. Individuals with average leptin concentrations had a higher risk of plasma vitamin E deficiency. Finally, those with sufficient leisure-time physical activity had a lower risk of serum vitamin D deficiency. CONCLUSIONS: Residents of the urban areas of São Paulo demonstrated substantially inadequate intakes of most of the assessed micronutrients; however, micronutrient deficiency in serum/plasma was not associated with dietary inadequacy, and it usually demonstrated a lower prevalence than dietary indicators. Thus, using micronutrient intake to determine the serum/plasma profile should be done with caution. The status of the micronutrients varied according to individual characteristics, indicating the interplay of complex mechanisms underlying micronutrient balance.
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Desnutrición , Micronutrientes , Oligoelementos , Vitaminas , Humanos , Masculino , Brasil/epidemiología , Estudios Transversales , Magnesio , Micronutrientes/deficiencia , Oligoelementos/deficiencia , Vitamina A , Vitamina D , Vitamina K , Zinc , Desnutrición/epidemiología , DietaRESUMEN
Background: Economic dimension comprises important determinants of food choices, particularly income and prices. Aim: Identification of the influence of food prices and diet costs on the consumption of food groups considered protection and risk factors for cardiometabolic diseases. Methods: Food groups classification follows the proposal of "What we eat in America?" from the National Health and Nutrition Examination Survey (NHANES), adapted to Latin America. Data on food consumption from the Health Survey of Sao Paulo (2003, 2008, and 2015), representative at population level, was used. Log-linear regressions were estimated for food groups, controlling for endogeneity through augmented regression-test Results: Results showed increase in prices per calorie of whole grains and red meat from 2003-2015 and a decrease in prices per calorie of fruits, vegetables, beans, legumes, oilseeds and fish/seafood. Food groups had price elasticities between -0.01 and -1.6, i.e., decrease in consumption associated with increase in prices. Results showed statistically significant effects of substitution and complementarity, particularly substitution between sweetened beverages and fruits (2003, ß = 0.606; 2008: ß = 0.683; 2015, ß = 0.848), complementarity between nuts and seeds and whole grains (2003, ß = -0.646; 2008, ß = -0.647; 2015,ß = -0.901), and vegetables and processed meat (2003, ß = -1.379; 2015, ß = -1.685). Conclusion: Findings of the study represent relevant evidence for design strategies towards the adoption of healthier diets, particularly through subsidies to protection food groups, promoting lower prices and higher diet quality. The evidence may be useful for policymakers and researchers in fields of nutrition and health in diverse countries worldwide, especially due to absence of robust evidence in literature.
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OBJECTIVES: To perform temporal evaluation of folate and vitamin B12 status and their associated factors in a Brazilian population exposed to mandatory fortification. METHODS: Data from the cross-sectional population-based studies 2008 and 2015 Health Surveys of São Paulo, including individuals ≥ 20 years, both sexes, N = 549 in 2008 and N = 610 in 2015. Folate and vitamin B12 biomarkers status, B-complex supplements and medications use, and dietary intake were assessed. RESULTS: Serum folate concentrations increased in the entire population, adults and older adults in 2015 compared to 2008, while serum vitamin B12 concentration increased only in older adults. B-complex supplement use raised in 2015, reflecting in serum vitamins status. Overall serum vitamin B12 deficiencies (<200 pg/mL) were 23.2% and 21.2%, while serum folate deficiencies (<4 ng/mL) were 4.1% and 1.5% in 2008 and 2015, respectively. The lowest quintile of serum folate (≤8.7 ng/mL) was positively associated with smoking and oral contraceptive use, while the highest quintile (≥17.8 ng/mL) was inversely associated with smoking and positively with B-complex supplement use. The odds of having vitamin B12 deficiency was inversely associated with B-complex supplement use, higher serum folate median, higher dietary vitamin B12 intake and positively associated with using oral contraceptive. CONCLUSION: Overall deficiency of folate has decreased in 2015, being almost non-existent. Low vitamin B12 status presented similar proportions in the overall population comparing both periods, except for older adults. Different predictive variables were identified to better understand vitamins status outcomes in the most recent period of the study.