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1.
Lang Speech ; : 238309231182363, 2023 Jul 26.
Artículo en Inglés | MEDLINE | ID: mdl-37496274

RESUMEN

This article investigates the role of phonological well-formedness constraints in Mandarin speakers' phonotactic grammar and how they affect online speech processing. Mandarin non-words can be categorized into systematic gaps and accidental gaps, depending on whether they violate principled phonotactic constraints based on the Obligatory Contour Principle (OCP). Non-word acceptability judgment experiments have shown that systematic gaps received lower wordlikeness ratings than accidental gaps. Using a lexical decision task, this study found that systematic gaps were rejected significantly faster than accidental gaps, even after lexical statistics were taken into account. These findings thus provide converging evidence for the essential status of the OCP-based phonotactic constraints in Mandarin speakers' phonological knowledge.

2.
Front Psychol ; 12: 735593, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34646215

RESUMEN

Although phonological alternation is prevalent in languages, the process of perceiving phonologically alternated sounds is poorly understood, especially at the neurolinguistic level. We examined the process of perceiving Mandarin 3rd tone sandhi (T3 + T3 → T2 + T3) with a mismatch negativity (MMN) experiment. Our design has two independent variables (whether the deviant undergoes tone sandhi; whether the standard and the deviant have matched underlying tone). These two independent variables modulated ERP responses in both the first and the second syllables. Notably, despite the apparent segmental conflict between the standard and the deviant in all conditions, MMN is only observed when neither the standard nor the deviant undergoes tone sandhi, suggesting that discovering the underlying representation of an alternated sound could interfere with the generation of MMN. A tentative model with three hypothesized underlying processing mechanisms is proposed to explain the observed latency and amplitude differences across conditions. The results are also discussed in light of the potential electrophysiological signatures involved in the process of perceiving alternated sounds.

3.
J Exp Psychol Learn Mem Cogn ; 47(7): 1106-1140, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33507779

RESUMEN

The present study examines both properties of the language and properties of the learner to better understand variability at the earliest stages of second language (L2) acquisition. We used event-related potentials, an oral production task, and a battery of individual differences measures to examine the processing of number and gender agreement in two groups of low-proficiency English-speaking learners of Spanish who were tested in multiple sessions. The results showed an advantage for number, the feature also instantiated in the native language, as both groups showed a native-like P600 response to subject-verb and noun-adjective number violations across sessions. The more advanced group showed larger effects for number and marginal sensitivity to gender violations. These results suggest that native-like processing of shared features is possible even for novice learners, contrary to proposals suggesting that all morphosyntactic dependencies are initially processed in a non-native manner. Working memory (WM) was a predictor of P600 effects for number and also for gender (where the effect was marginal), suggesting that similar abilities may capture variability in the processing of both shared and unique features despite differences in overall sensitivity. Furthermore, whereas WM predicted performance on online tasks (P600 effects/oral production), verbal aptitude predicted performance on tasks examining morphosyntactic accuracy (grammaticality judgment task/oral production). Our results show that the linguistic properties of the L2, the individual characteristics of the learner, and the nature of the task at hand all play an important role in capturing the variability often observed in the L2 processing of agreement. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Asunto(s)
Multilingüismo , Electroencefalografía , Potenciales Evocados , Humanos , Lenguaje , Aprendizaje
4.
Front Psychol ; 11: 646, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32322230

RESUMEN

Phonological alternation (sound change depending on the phonological environment) poses challenges to spoken word recognition models. Mandarin Chinese T3 sandhi is such a phenomenon in which a tone 3 (T3) changes into a tone 2 (T2) when followed by another T3. In a mismatch negativity (MMN) study examining Mandarin Chinese T3 sandhi, participants passively listened to either a T2 word [tʂu2 je4] /tʂu2 je4/, a T3 word [tʂu3 je4] /tʂu3 je4/, a sandhi word [tʂu2 jen3] /tʂu3 jen3/, or a mix of T3 and sandhi word standards. The deviant in each condition was a T2 word [tʂu2]. Results showed an MMN only in the T2 and T3 conditions but not in the Sandhi or Mix conditions. All conditions also yielded omission MMNs. This pattern cannot be explained based on the surface forms of standards and deviants; rather these data suggest an underspecified or underlying T3 stored linguistic representation used in spoken word processing.

5.
Front Psychol ; 9: 1720, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30294290

RESUMEN

The derivation of scalar implicatures for the quantifier some has been widely studied to investigate the computation of pragmatically enriched meanings. For example, the sentence "I found some books" carries the semantic interpretation that at least one book was found, but its interpretation is often enriched to include the implicature that not all the books were found. The implicature is argued to be more likely to arise when it is relevant for addressing a question under discussion (QUD) in the context, e.g., when "I found some books" is uttered in response to "Did you find all the books?" as opposed to "Did you find any books?". However, most experimental studies have not examined the influence of context on some, instead testing some sentences in isolation. Moreover, no study to our knowledge has examined individual differences in the ability to utilize context in interpreting some, whereas individual variation in deriving implicatures for some sentences in isolation is widely attested, with alternative proposals attributing this variation to individual differences in cognitive resources (e.g., working memory) or personality-based pragmatic abilities (e.g., as assessed by the Autism-Spectrum Quotient). The current study examined how context influences the interpretation of some in a story-sentence matching task, where participants rated some statements ("I cut some steaks") uttered by one character, in response to another character's question (QUD) that established the implicature as relevant ("Did you cut all the steaks?") or irrelevant ("Did you cut any steaks?"). We also examined to what extent individuals' sensitivity to QUD is modulated by individual differences via a battery of measures assessing cognitive resources, personality-based pragmatic abilities, and language abilities (which have been argued to modulate comprehension in other domains). Our results demonstrate that QUD affects the interpretation of some, and reveal that individual differences in sensitivity to QUD are modulated by both cognitive resources and personality-based pragmatic abilities. While previous studies have argued alternatively for cognitive resources or personality-based pragmatic abilities as important for deriving implicatures for some in isolation, we argue that arriving at a context-sensitive interpretation for some depends on both cognitive and personality-based properties of the individual.

6.
PLoS One ; 13(7): e0200791, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30052686

RESUMEN

We used event-related potentials to investigate morphosyntactic development in 78 adult English-speaking learners of Spanish as a second language (L2) across the proficiency spectrum. We examined how development is modulated by the similarity between the native language (L1) and the L2, by comparing number (a feature present in English) and gender agreement (novel feature). We also investigated how development is impacted by structural distance, manipulating the distance between the agreeing elements by probing both within-phrase (fruta muy jugosa "fruit-FEM-SG very juicy-FEM-SG") and across-phrase agreement (fresa es ácida "strawberry-FEM-SG is tart-FEM-SG"). Regression analyses revealed that the learners' overall proficiency, as measured by a standardized test, predicted their accuracy with the target properties in the grammaticality judgment task (GJT), but did not predict P600 magnitude to the violations. However, a relationship emerged between immersion in Spanish-speaking countries and P600 magnitude for gender. Our results also revealed a correlation between accuracy in the GJT and P600 magnitude, suggesting that behavioral sensitivity to the target property predicts neurophysiological sensitivity. Subsequent group analyses revealed that the highest-proficiency learners showed equally robust P600 effects for number and gender. This group also elicited more positive waveforms for within- than across-phrase agreement overall, similar to the native controls. The lowest-proficiency learners showed a P600 for number overall, but no effects for gender. Unlike the highest-proficiency learners, they also showed no sensitivity to structural distance, suggesting that sensitivity to such linguistic factors develops over time. Overall, these results suggest an important role for proficiency in morphosyntactic development, although differences emerged between behavioral and electrophysiological measures. While L2 proficiency predicted behavioral sensitivity to agreement, development with respect to the neurocognitive mechanisms recruited in processing only emerged when comparing the two extremes of the proficiency spectrum. Importantly, while both L1-L2 similarity and hierarchical structure impact development, they do not constrain it.


Asunto(s)
Encéfalo/fisiología , Potenciales Evocados/fisiología , Lenguaje , Aprendizaje/fisiología , Multilingüismo , Semántica , Adulto , Mapeo Encefálico , Electroencefalografía , Femenino , Humanos , Masculino , Adulto Joven
7.
Neurosci Lett ; 673: 79-84, 2018 04 23.
Artículo en Inglés | MEDLINE | ID: mdl-29444445

RESUMEN

The present study examines the processing of referential ambiguity and referential failure using event-related potentials (ERPs). Participants read sentences with pronouns (he, she) which contained either one, two, or no potential gender-matching antecedents. Participants also took tests of working memory (Count Span/Reading Span) and attentional control (Number Stroop). In contexts of referential ambiguity with two potential gender-matching antecedents, two different responder types emerged, with some participants yielding a sustained negativity (Nref) and others a sustained positivity. For individuals who elicited Nref, the size of the effect was related to working memory such that higher Count Span scores were related to a larger Nref. For individuals who elicited a positivity, the effect was marginally related to attentional control such that better performance on the Stroop was related to a less positive, or increasingly negative-going ERP effect. Contexts of referential failure, with no gender-matching antecedents, yielded P600 for all participants, suggesting that participants may treat the failure of the pronoun to agree in gender with the antecedents as a violation despite the absence of an explicit acceptability judgment task.


Asunto(s)
Encéfalo/fisiología , Potenciales Evocados , Individualidad , Lingüística , Lectura , Adolescente , Adulto , Atención , Comprensión , Electroencefalografía , Femenino , Humanos , Masculino , Memoria a Corto Plazo , Adulto Joven
8.
Neuroreport ; 28(10): 561-564, 2017 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-28538518

RESUMEN

Using fetal biomagnetometry, this study measured changes in fetal heart rate to assess discrimination of two rhythmically different languages (English and Japanese). Two-minute passages in English and Japanese were read by the same female bilingual speaker. Twenty-four mother-fetus pairs (mean gestational age=35.5 weeks) participated. Fetal magnetocardiography was recorded while the participants were presented first with passage 1, a passage in English, and then, following an 18 min interval, with passage 2, either a different passage in English (English-English condition: N=12) or in Japanese (English-Japanese condition: N=12). The fetal magnetocardiogram was reconstructed following independent components analysis decomposition. The mean interbeat intervals were calculated for a 30 s baseline interval directly preceding each passage and for the first 30 s of each passage. We then subtracted the mean interbeat interval of the 30 s baseline interval from that of the first 30 s interval, yielding an interbeat interval change value for each passage. A significant interaction between condition and passage indicated that the English-Japanese condition elicited a more robust interbeat interval change for passage 2 (novelty phase) than for passage 1 (familiarity phase), reflecting a faster heart rate during passage 2, whereas the English-English condition did not. This effect indicates that fetuses are sensitive to the change in language from English to Japanese. These findings provide the first evidence for fetal language discrimination as assessed by fetal biomagnetometry and support the hypothesis that rhythm constitutes a prenatally available building block in language acquisition.


Asunto(s)
Discriminación en Psicología , Lenguaje , Periodicidad , Tercer Trimestre del Embarazo , Percepción del Habla , Estimulación Acústica , Adulto , Análisis de Varianza , Discriminación en Psicología/fisiología , Femenino , Corazón/embriología , Corazón/fisiología , Frecuencia Cardíaca , Humanos , Magnetocardiografía , Patrones de Reconocimiento Fisiológico/fisiología , Embarazo , Tercer Trimestre del Embarazo/fisiología , Tercer Trimestre del Embarazo/psicología , Pruebas Psicológicas , Percepción del Habla/fisiología , Adulto Joven
9.
J Pediatr Gastroenterol Nutr ; 65(3): 272-277, 2017 09.
Artículo en Inglés | MEDLINE | ID: mdl-27875488

RESUMEN

OBJECTIVES: Food and Drug Administration approval of proton-pump inhibitors for infantile gastroesophageal reflux disease has been limited by intrapatient variability in the clinical assessment of gastroesophageal reflux disease. For children 1 to 17 years old, extrapolating efficacy from adults for IV esomeprazole was accepted. The oral formulation was previously approved in children. Exposure-response and exposure matching analyses were sought to identify approvable pediatric doses. METHODS: Intragastric pH biomarker comparisons between children and adults were conducted. Pediatric doses were selected to match exposures in adults and were based on population pharmacokinetic (PK) modeling and simulations with pediatric esomeprazole data. Observed IV or oral esomeprazole PK data were available from 50 and 117 children, between birth and 17 years, respectively, and from 65 adults, between 20 and 48 years. A population PK model developed using these data was used to simulate steady-state esomeprazole exposures for children at different doses to match the observed exposures in adults. RESULTS: Exposure-response relationships of intragastric pH measures were similar between children and adults. The PK simulations identified a dosing regimen for children that results in comparable steady-state area under the curve to that observed after 20 mg in adults. For IV esomeprazole, increasing the infusion duration to 10 to 30 minutes in children achieves matching Cmax values with adults. CONCLUSIONS: The exposure-matching analysis permitted approval of an esomeprazole regimen not studied directly in clinical trials. Exposure-response for intragastric pH-permitted approval for the treatment of gastroesophageal reflux disease in children in whom it was not possible to evaluate the adult primary endpoint, mucosal healing assessed by endoscopy.


Asunto(s)
Aprobación de Drogas/métodos , Esomeprazol/administración & dosificación , Reflujo Gastroesofágico/tratamiento farmacológico , Inhibidores de la Bomba de Protones/administración & dosificación , United States Food and Drug Administration , Administración Oral , Adolescente , Adulto , Área Bajo la Curva , Niño , Preescolar , Relación Dosis-Respuesta a Droga , Cálculo de Dosificación de Drogas , Esomeprazol/farmacocinética , Esomeprazol/uso terapéutico , Femenino , Reflujo Gastroesofágico/metabolismo , Humanos , Lactante , Recién Nacido , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Inhibidores de la Bomba de Protones/farmacocinética , Inhibidores de la Bomba de Protones/uso terapéutico , Resultado del Tratamiento , Estados Unidos , Adulto Joven
10.
Front Psychol ; 7: 549, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27148152

RESUMEN

There is a debate as to whether second language (L2) learners show qualitatively similar processing profiles as native speakers or whether L2 learners are restricted in their ability to use syntactic information during online processing. In the realm of wh-dependency resolution, research has examined whether learners, similar to native speakers, attempt to resolve wh-dependencies in grammatically licensed contexts but avoid positing gaps in illicit contexts such as islands. Also at issue is whether the avoidance of gap filling in islands is due to adherence to syntactic constraints or whether islands simply present processing bottlenecks. One approach has been to examine the relationship between processing abilities and the establishment of wh-dependencies in islands. Grammatical accounts of islands do not predict such a relationship as the parser should simply not predict gaps in illicit contexts. In contrast, a pattern of results showing that individuals with more processing resources are better able to establish wh-dependencies in islands could conceivably be compatible with certain processing accounts. In a self-paced reading experiment which examines the processing of wh-dependencies, we address both questions, examining whether native English speakers and Korean learners of English show qualitatively similar patterns and whether there is a relationship between working memory, as measured by counting span and reading span, and processing in both island and non-island contexts. The results of the self-paced reading experiment suggest that learners can use syntactic information on the same timecourse as native speakers, showing qualitative similarity between the two groups. Results of regression analyses did not reveal a significant relationship between working memory and the establishment of wh-dependencies in islands but we did observe significant relationships between working memory and the processing of licit wh-dependencies. As the contexts in which these relationships emerged differed for learners and native speakers, our results call for further research examining individual differences in dependency resolution in both populations.

11.
J Psycholinguist Res ; 45(3): 575-97, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25840671

RESUMEN

Whether morpheme-based processing extends to relatively unproductive derived words remains a matter of debate. Although whole-word storage and access has been proposed for some derived words, such as Japanese de-adjectival nominals with the unproductive (-mi) suffix (e.g., Hagiwara et al. in Language 75:739-763, 1999), Clahsen and Ikemoto (Ment Lex 7:147-182, 2012) found masked priming from de-adjectival nominals with productive (-sa) and unproductive (-mi) suffixes to their adjectivally-inflected base morpheme. Using masked and unmasked priming, we examine whether adjectivally-inflected base morpheme primes facilitate the processing of Japanese de-adjectival nominal targets with a productive or unproductive affix, including an orthographic-overlap condition and semantic relatedness measure that Clahsen and Ikemoto (2012) did not include. Our results replicate and extend Clahsen and Ikemoto (2012), revealing significant, statistically-equivalent morphological priming effects for -sa and -mi affixed targets, independent of orthographic and semantic relatednesss, suggesting that the processing of derived words with the unproductive -mi affix makes recourse to morpheme-level representations.


Asunto(s)
Reconocimiento Visual de Modelos/fisiología , Enmascaramiento Perceptual/fisiología , Psicolingüística , Lectura , Memoria Implícita/fisiología , Adulto , Humanos , Japón
12.
Ment Lex ; 10(3): 413-434, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-29142611

RESUMEN

Recent research suggests that visually-presented words are initially morphologically segmented whenever the letter-string can be exhaustively assigned to existing morphological representations, but not when an exhaustive parse is unavailable; e.g., priming is observed for both hunter→HUNT and brother →BROTH, but not for brothel→BROTH. Few studies have investigated whether this pattern extends to novel complex words, and the results to date (all from novel suffixed words) are mixed. In the current study, we examine whether novel compounds (drugrack→RACK) yield morphological priming which is dissociable from that in novel pseudoembedded words (slegrack→RACK). Using masked priming, we find significant and comparable priming in reaction times for word-final elements of both novel compounds and novel pseudoembedded words. Using overt priming, however, we find greater priming effects (in both reaction times and N400 amplitudes) for novel compounds compared to novel pseudoembedded words. These results are consistent with models assuming across-the-board activation of putative constituents, while also suggesting that morpheme activation may persevere despite the lack of an exhaustive morpheme-based parse when an exhaustive monomorphemic analysis is also unavailable. These findings highlight the critical role of the lexical status of the pseudoembedded prime in dissociating morphological and orthographic priming.

13.
Cogn Neuropsychol ; 31(1-2): 123-46, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24279696

RESUMEN

The extent to which the processing of compounds (e.g., "catfish") makes recourse to morphological-level representations remains a matter of debate. Moreover, positing a morpheme-level route to complex word recognition entails not only access to morphological constituents, but also combinatoric processes operating on the constituent representations; however, the neurophysiological mechanisms subserving decomposition, and in particular morpheme combination, have yet to be fully elucidated. The current study presents electrophysiological evidence for the morpheme-based processing of both lexicalized (e.g., "teacup") and novel (e.g., "tombnote") visually presented English compounds; these brain responses appear prior to and are dissociable from the eventual overt lexical decision response. The electrophysiological results reveal increased negativities for conditions with compound structure, including effects shared by lexicalized and novel compounds, as well as effects unique to each compound type, which may be related to aspects of morpheme combination. These findings support models positing across-the-board morphological decomposition, counter to models proposing that putatively complex words are primarily or solely processed as undecomposed representations, and motivate further electrophysiological research toward a more precise characterization of the nature and neurophysiological instantiation of complex word recognition.


Asunto(s)
Encéfalo/fisiología , Electroencefalografía , Lenguaje , Semántica , Vocabulario , Adolescente , Femenino , Humanos , Masculino , Psicolingüística , Adulto Joven
14.
PLoS One ; 8(5): e63943, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23696860

RESUMEN

Scalar inference is the phenomenon whereby the use of a less informative term (e.g., some of) is inferred to mean the negation of a more informative term (e.g., to mean not all of). Default processing accounts assume that the interpretation of some of as meaning not all of is realized easily and automatically (regardless of context), whereas context-driven processing accounts assume that it is realized effortfully and only in certain contexts. In the present study, participants' self-paced reading times were recorded as they read vignettes in which the context did or did not bias the participants to make a scalar inference (to interpret some of as meaning not all of). The reading times suggested that the realization of the inference was influenced by the context, but did not provide evidence for processing cost at the time the inference is realized, contrary to the predictions of context-driven processing accounts. The results raise the question of why inferencing occurs only in certain contexts if it does not involve extra processing effort.


Asunto(s)
Interpretación Estadística de Datos , Lenguaje , Encéfalo , Humanos , Modelos Teóricos
15.
Brain Res ; 1490: 134-52, 2013 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-23103410

RESUMEN

The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading infelicitous quantifiers for which the semantic meaning was correct with respect to the context but the pragmatic meaning was not, compared to quantifiers for which the semantic meaning was inconsistent with the context and no additional pragmatic meaning is available. In the first experiment, only pragmatically inconsistent quantifiers, not semantically inconsistent quantifiers, elicited a sustained posterior negative component. This late negativity contrasts with the N400 effect typically elicited by nouns that are incongruent with their context, suggesting that the recognition of scalar implicature errors elicits a qualitatively different ERP signature than the recognition of lexico-semantic errors. We hypothesize that the sustained negativity reflects cancellation of the pragmatic inference and retrieval of the semantic meaning. In our second experiment, we found that the process of re-interpreting the quantifier was independent from lexico-semantic processing: the N400 elicited by lexico-semantic violations was not modulated by the presence of a pragmatic inconsistency. These findings suggest that inferential pragmatic aspects of meaning are processed using different mechanisms than lexical or combinatorial semantic aspects of meaning, that inferential pragmatic meaning can be realized rapidly, and that the computation of meaning involves continuous negotiation between different aspects of meaning.


Asunto(s)
Encéfalo/fisiología , Comprensión/fisiología , Potenciales Evocados/fisiología , Semántica , Estimulación Acústica , Adolescente , Adulto , Análisis de Varianza , Pueblo Asiatico , Interpretación Estadística de Datos , Electroencefalografía , Femenino , Humanos , Lenguaje , Masculino , Estimulación Luminosa , Desempeño Psicomotor/fisiología , Lectura , Adulto Joven
16.
Neurosci Lett ; 534: 246-51, 2013 Feb 08.
Artículo en Inglés | MEDLINE | ID: mdl-23219620

RESUMEN

The present study examines the online realization of pragmatic meaning using event-related potentials (ERPs). Participants read sentences including the English quantifier some, which has both a semantic meaning (at least one) and a pragmatic meaning (not all). Unlike previous ERP studies of this phenomenon, sentences in the current study were evaluated not in terms of their truth with respect to the real world, but in terms of their consistency with a picture presented before the sentence. Sentences (such as "The boy cut some of the steaks in this story") were constructed such that either (1) both the semantic and pragmatic interpretations were true with respect to the preceding picture (when the boy in fact cut some but not all of the steaks); (2) neither interpretation was true (when the boy in fact cut none of the steaks); or (3) the semantic interpretation was true but the pragmatic interpretation false (when the boy in fact cut all of the steaks). ERPs at the object word, which determined whether the sentence was consistent with the story, showed the largest N400 effect for objects that made the sentence false, whereas they showed an intermediate effect for objects that made the sentence false under the pragmatic interpretation but true under the semantic interpretation. The results suggest that this pragmatic aspect of meaning is computed online and integrated into the sentence model rapidly enough to influence comprehension of later words.


Asunto(s)
Comprensión , Potenciales Evocados , Semántica , Percepción Visual , Adolescente , Adulto , Electroencefalografía , Femenino , Humanos , Masculino , Estimulación Luminosa , Adulto Joven
17.
J Allergy Clin Immunol ; 130(3): 613-6, 2012 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-22857796

RESUMEN

Like many rare diseases, eosinophilic esophagitis (EoE) is a poorly understood disorder, and assessment tools to accurately determine disease activity, remission, and natural history have long been inadequate. Clinical outcome end points able to assess the effectiveness of candidate therapeutic agents in clinical trials have been a particular deficiency and are urgently needed. With no approved therapy available to patients and with the prevalence of EoE on the increase, collaborative approaches to drug development are becoming ever more important. We describe a collaborative effort mobilized across institutions, including both the public and private sectors, that was initiated within the past 18 months expressly to address the need for further clinical research into the cause and treatment of EoE. Collaborators include the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition; the International Gastrointestinal Eosinophilic Researchers; and the US Food and Drug Administration. This effort has resulted in the elucidation of several parameters essential for effective EoE registration trials, including the need for clinically meaningful end points that measure changes in clinical symptoms in addition to the assessment of intraepithelial mucosal eosinophilia. The development and use of biomarkers, particularly in early-phase drug development, have become an important focus for investigations that might reduce clinical reliance on serial invasive monitoring. The concerted efforts described here to develop rational therapeutics and drug development paradigms in EoE also appear to provide a model for effective collaboration in the context of drug development for rare diseases and perhaps more generally for public health initiatives.


Asunto(s)
Descubrimiento de Drogas , Esofagitis Eosinofílica/tratamiento farmacológico , Enfermedades Raras/tratamiento farmacológico , Conducta Cooperativa , Humanos
18.
Brain Res ; 1456: 49-63, 2012 May 25.
Artículo en Inglés | MEDLINE | ID: mdl-22520436

RESUMEN

Previous research suggests that the processing of agreement is affected by the distance between the agreeing elements. However, the unique contribution of structural distance (number of intervening syntactic phrases) to the processing of agreement remains an open question, since previous investigations do not tease apart structural and linear distance (number of intervening words). We used event-related potentials (ERPs) to examine the extent to which structural distance impacts the processing of Spanish number and gender agreement. Violations were realized both within the phrase and across the phrase. Across both levels of structural distance, linear distance was kept constant, as was the syntactic category of the agreeing elements. Number and gender agreement violations elicited a robust P600 between 400 and 900 ms, a component associated with morphosyntactic processing. No amplitude differences were observed between number and gender violations, suggesting that the two features are processed similarly at the brain level. Within-phrase agreement yielded more positive waveforms than across-phrase agreement, both for agreement violations and for grammatical sentences (no agreement by distance interaction). These effects can be interpreted as evidence that structural distance impacts the establishment of agreement overall, consistent with sentence processing models which predict that hierarchical structure impacts the processing of syntactic dependencies. However, due to the lack of an agreement by distance interaction, the possibility cannot be ruled out that these effects are driven by differences in syntactic predictability between the within-phrase and across-phrase configurations, notably the fact that the syntactic category of the critical word was more predictable in the within-phrase conditions.


Asunto(s)
Comprensión/fisiología , Potenciales Evocados/fisiología , Lenguaje , Lectura , Semántica , Adolescente , Adulto , Mapeo Encefálico , Electroencefalografía , Femenino , Humanos , Masculino , Estimulación Luminosa , Procesamiento de Señales Asistido por Computador , Adulto Joven
19.
Ment Lex ; 7(1): 34-57, 2012 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-25083167

RESUMEN

Compound formation has been a major focus of research and debate in mental lexicon research. In particular, it has been widely observed that compounds with a regular plural non-head are dispreferred, and a long line of research has examined the nature of this constraint, including which morphological, semantic or phonological properties of the non-head underlie this dispreference. While it is typically assumed that this constraint in fact leads to the barring of a compound analysis to a noun-noun string which would otherwise violate the constraint, its implementation during sentence comprehension has not been thoroughly examined. Using self-paced reading, we demonstrate that knowledge of pluralization and compound formation is immediately utilized in the assignment of structure to noun-noun strings, and that the dispreference for regular plural non-heads in fact leads the parser away from the compound analysis in favor of a more complex grammatical alternative. These results provide new evidence for the online deployment of knowledge regarding pluralization and its interaction with compound formation, and inform our understanding of how morphological information is deployed during, and impacts real-time sentence comprehension.

20.
Brain Lang ; 106(1): 65-71, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18417201

RESUMEN

Masked priming is used in psycholinguistic studies to assess questions about lexical access and representation. We present two masked priming experiments using MEG. If the MEG signal elicited by words reflects specific aspects of lexical retrieval, then one expects to identify specific neural correlates of retrieval that are sensitive to priming. To date, the electrophysiological evidence has been equivocal. We report findings from two experiments. Both employed identity priming, where the prime and target are the same lexical item but differ in case (NEWS-news). The first experiment used only forward masking, while the prime in the second experiment was both preceded and followed by a mask (backward masking). In both studies, we find a significant behavioral effect of priming. Using MEG, we identified a component peaking approximately 225 ms post-onset of the target, whose latency was sensitive to repetition. These findings support the notion that properties of the MEG response index specific lexical processes and demonstrate that masked priming can be effectively combined with MEG to investigate the nature of lexical processing.


Asunto(s)
Magnetoencefalografía/métodos , Enmascaramiento Perceptual/fisiología , Semántica , Percepción Visual/fisiología , Adulto , Electrofisiología/métodos , Femenino , Humanos , Lenguaje , Masculino , Reconocimiento Visual de Modelos/fisiología , Estimulación Luminosa/métodos , Psicolingüística/métodos , Psicofísica/métodos , Tiempo de Reacción/fisiología , Vocabulario , Pruebas de Asociación de Palabras
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